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New pill shows promise for Hard-to-Treat cancers

NCT ID NCT03556228

Recruiting now Disease control Sponsor: VM Oncology, LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another cancer drug (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have not responded to or are no longer controlled by available treatments. The goal is to check safety, find the best dose, and see if it can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
VMD-928 (a pill) and pembrolizumab (an immunotherapy drug)
What this could lead to
If successful, this could provide a new treatment option for people with certain advanced cancers that have stopped responding to other therapies.
What could go wrong
This is an early-phase trial with a small number of participants, so the drug may not prove effective or may cause significant side effects. It is not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenoid cystic carcinoma esophageal cancer Esophageal Neoplasms head and neck cancer head and neck carcinoma Head and Neck Neoplasms head and neck squamous cell carcinoma hypopharynx cancer laryngeal disorder larynx cancer lip cancer lung cancer lung neoplasm malignant pancreatic neoplasm malignant tumor of nasopharynx mesothelioma nasopharyngeal carcinoma Neoplasm Metastasis non-small cell lung carcinoma NTRK fusion positive cancer oral cavity cancer oropharynx cancer pancreatic neoplasm salivary gland cancer salivary gland carcinoma small cell lung carcinoma Squamous Cell Carcinoma of Head and Neck tonsil cancer tracheal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOID CYSTIC CARCINOMA ANY SOLID TUMORS PROGRESSED AFTER A PRIOR IMMUNOTHERAPY ESOPHAGEAL CANCER HEAD AND NECK CANCERS HEAD AND NECK CANCERS - NASOPHARYNGEAL HEAD AND NECK CANCERS - SALIVARY GLAND HEAD AND NECK CANCERS - THROAT HEAD AND NECK CANCERS - TONSILS HEAD AND NECK CANCERS HYPOPHARYNX HEAD AND NECK CANCERS LARYNX HEAD AND NECK CANCERS LIP HEAD AND NECK CANCERS NASOPHARYNX HEAD AND NECK CANCERS ORAL CAVITY HEAD AND NECK CANCERS OROPHARYNX HEAD AND NECK CANCERS TRACHEA HEAD AND NECK CARCINOMA HEAD AND NECK SQUAMOUS CELL CARCINOMA HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) LUNG CANCER LUNG CANCER (LOCALLY ADVANCED OR METASTATIC) MESOTHELIOMA NON-SMALL CELL LUNG CANCER PANCREATIC CANCER SALIVARY GLAND CARCINOMAS SMALL CELL LUNG CANCER ( SCLC )

Contacts and locations

Locations

  • Atlantic Health System, Morristown Medical Center (site 124)

    RECRUITING

    Morristown, New Jersey, 07962, United States

  • Cancer Care Associates of York (site 206)

    RECRUITING

    York, Pennsylvania, 17403, United States

  • Englewood Hospital and Medical Center (site 202)

    RECRUITING

    Englewood, New Jersey, 07631, United States

  • Hartford Hospital (site 210)

    RECRUITING

    Hartford, Connecticut, 06102, United States

  • Holy Cross Hospital (site 213)

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

  • Memorial Cancer Institute at Memorial Healthcare Systems (site 132)

    RECRUITING

    Pembroke Pines, Florida, 33028, United States

  • PanOncology Trials, Hospital Oncologico - Puerto Rico Medical Center, Río Piedras (site 200)

    RECRUITING

    San Juan, 00935, Puerto Rico

  • Presbyterian Kaseman Hospital (site 208)

    RECRUITING

    Albuquerque, New Mexico, 87110, United States

  • Providence Medical Foundation (site 209)

    RECRUITING

    Santa Rosa, California, 95403, United States

  • Summit Medical Group (site 205)

    RECRUITING

    Florham Park, New Jersey, 07932, United States

  • Taylor Cancer Research Center (site 204)

    RECRUITING

    Maumee, Ohio, 43537, United States

  • The George Washington University Cancer Center (site 212)

    RECRUITING

    Washington D.C., District of Columbia, 20037, United States

  • The University of Texas MD Anderson Cancer Center (site 127)

    RECRUITING

    Houston, Texas, 77030, United States

  • Utah Cancer Specialists (site 203)

    RECRUITING

    Salt Lake City, Utah, 84106, United States

  • Weill Cornell Medicine, Cornell University (site 126)

    RECRUITING

    New York, New York, 10065, United States

More trials for these conditions

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