Could a Twice-Yearly shot prevent heart attacks and amputations?
NCT ID NCT06909565
First seen Jan 09, 2026 · Last updated May 17, 2026 · Updated 19 times
Summary
This study tests whether inclisiran, a twice-yearly injection that lowers bad cholesterol, can prevent major heart and limb events in 6,000 adults who recently had artery-opening procedures. Participants receive either inclisiran or a placebo, and researchers track heart attacks, strokes, and limb complications over time. The goal is to see if this easy-to-take medication reduces risks beyond standard care.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Advanced Cardiovascular LLC
RECRUITINGAlexander City, Alabama, 35010, United States
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Advanced Heart Care LLC
RECRUITINGBridgewater, New Jersey, 08807, United States
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Advanced Heart and Vascular Institute Of Hunterdon
RECRUITINGFlemington, New Jersey, 08822, United States
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Amarillo Heart Clinical Research Institute, Inc.
RECRUITINGAmarillo, Texas, 79124, United States
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AnMed Health Medical Center
RECRUITINGAnderson, South Carolina, 29621, United States
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Apex Research Foundation, LLC
RECRUITINGJackson, Tennessee, 38301, United States
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Arkansas Cardiology
RECRUITINGLittle Rock, Arkansas, 72205, United States
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Arrow Clinical Trails
RECRUITINGDaytona Beach, Florida, 32117, United States
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Asheville Cardiology Associates Research Department
RECRUITINGAsheville, North Carolina, 28803, United States
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Aspirus Saint Luke's Hospital
RECRUITINGDuluth, Minnesota, 55805, United States
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Atlanta Heart Specialists LLC
RECRUITINGTucker, Georgia, 30084, United States
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AtlantiCare Regional Medical Center
RECRUITINGPomona, New Jersey, 08240, United States
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Aultman Hospital
RECRUITINGCanton, Ohio, 44710, United States
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Austin Heart
RECRUITINGAustin, Texas, 78705, United States
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Austin Heart
RECRUITINGSan Marcos, Texas, 78666, United States
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Austin Heart PLLC
RECRUITINGRound Rock, Texas, 78681, United States
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BayCare Medical Group
RECRUITINGClearwater, Florida, 33756, United States
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Bryan Heart
RECRUITINGLincoln, Nebraska, 68506, United States
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CHI Health Nebraska Heart
RECRUITINGGrand Island, Nebraska, 68803, United States
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CHI Health Nebraska Heart
RECRUITINGLincoln, Nebraska, 68526, United States
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Capital Area Research LLC
RECRUITINGCamp Hill, Pennsylvania, 17011, United States
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Capitol Cardiology Associates PA
RECRUITINGLanham, Maryland, 20706, United States
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Cardiology Associates of Fairfield County
RECRUITINGStamford, Connecticut, 06305, United States
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Cardiology Associates of North Mississippi
RECRUITINGTupelo, Mississippi, 38801, United States
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Cardiology Associates of West Reading
RECRUITINGWest Reading, Pennsylvania, 19611, United States
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Cardiology, PC
RECRUITINGBirmingham, Alabama, 35211, United States
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Cardiovascular Associates of the Delaware Valley
RECRUITINGElmer, New Jersey, 08318, United States
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Cardiovascular Associates of the Delaware Valley
RECRUITINGHaddon Heights, New Jersey, 08035, United States
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Cardiovascular Associates of the Delaware Valley
RECRUITINGSewell, New Jersey, 08080, United States
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Cardiovascular Institute of Northwest Florida
RECRUITINGPanama City, Florida, 32405, United States
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Cardiovascular Solutions, LLC
RECRUITINGShreveport, Louisiana, 71103, United States
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Charlotte Heart & Vascular Center, PA
RECRUITINGPort Charlotte, Florida, 33948, United States
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Chippenham Hospital
RECRUITINGRichmond, Virginia, 23225, United States
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Clearwater Cardiovascular Consultants
RECRUITINGClearwater, Florida, 33756, United States
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Clearwater Cardiovascular Consultants
RECRUITINGSafety Harbor, Florida, 34695, United States
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Clearwater Cardiovascular and Interventional Consultants- Bardmoor
RECRUITINGLargo, Florida, 33777, United States
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Duke Cardiology
RECRUITINGMorrisville, North Carolina, 27560, United States
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FOMAT - West Coast Research Center
RECRUITINGVentura, California, 93030, United States
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Genesis HealthCare System
RECRUITINGZanesville, Ohio, 43701, United States
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Grace Research, LLC
RECRUITINGBossier City, Louisiana, 71111, United States
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Healthy Heart Cardiology at Rochester Hills (Advanced Cardiology Associates
RECRUITINGRochester Hills, Michigan, 48307, United States
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Heart Center Research, LLC
RECRUITINGHuntsville, Alabama, 35801, United States
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Heart House Research Foundation LLC
RECRUITINGSpringfield, Ohio, 45505, United States
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Heart Institute of East Texas
RECRUITINGLufkin, Texas, 75904, United States
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Hudson Valley Cardiovascular Practice PC
RECRUITINGPoughkeepsie, New York, 12601, United States
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Hudson Valley Cardiovascular Practice, PC
RECRUITINGPoughkeepsie, New York, 12601, United States
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Inpatient Research Clinic, LLC
RECRUITINGMiami Lakes, Florida, 33014, United States
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Interventional Cardiology Medical Group
RECRUITINGWest Hills, California, 91307, United States
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Iowa Heart Center
RECRUITINGWest Des Moines, Iowa, 50266, United States
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JAVARA Inc, - Mankato Clinic
RECRUITINGMankato, Minnesota, 56001, United States
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Jadestone Clinical Research, LLC
RECRUITINGSilver Spring, Maryland, 20904, United States
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Javara Inc.
RECRUITINGFayetteville, North Carolina, 28304, United States
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Javara inc.
RECRUITINGConroe, Texas, 77384, United States
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Javara, Inc.
RECRUITINGPeachtree City, Georgia, 30269, United States
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Louisiana Heart Center
RECRUITINGCovington, Louisiana, 70433, United States
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Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
RECRUITINGTorrance, California, 90502, United States
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Mecklenburg Heart Specialists
RECRUITINGCharlotte, North Carolina, 28207, United States
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Midwest Cardiovascular Research and Education Foundation
RECRUITINGElkhart, Indiana, 46514, United States
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Midwest Heart and Vascular Specialists
RECRUITINGOverland Park, Kansas, 66211, United States
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Monroe Research LLC
RECRUITINGWest Monroe, Louisiana, 71291, United States
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Mount Sinai School of Medicine
RECRUITINGNew York, New York, 10029, United States
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MultiCare Institute for Research and Innovation
RECRUITINGPuyallup, Washington, 98372, United States
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MultiCare Institute for Research and Innovation
RECRUITINGTacoma, Washington, 98405, United States
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MyMichigan Medical Center Midland
RECRUITINGMidland, Michigan, 48670, United States
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Northeast Georgia Heart Center, PC
RECRUITINGGainesville, Georgia, 30501, United States
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Northern Light Eastern Maine Medical Center
RECRUITINGBangor, Maine, 04401, United States
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Northwest Houston Heart Center
RECRUITINGTomball, Texas, 77375, United States
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Nuvance Health- Danbury Hospital
RECRUITINGDanbury, Connecticut, 06810, United States
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Pacific Oaks Medical Group
RECRUITINGBeverly Hills, California, 90211, United States
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PharmaTex Research
RECRUITINGAmarillo, Texas, 79106, United States
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Pioneer Clinical Studies
RECRUITINGCoral Gables, Florida, 33134, United States
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Radin Cardiovascular Medical Group, Inc
RECRUITINGNewport Beach, California, 92663, United States
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Reid Physician Associates
RECRUITINGRichmond, Indiana, 47374, United States
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Research Integrity, LLC
RECRUITINGOwensboro, Kentucky, 42303, United States
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Richmond University Medical Center
RECRUITINGStaten Island, New York, 10310, United States
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Riverside Community Hospital
RECRUITINGRiverside, California, 92501, United States
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San Diego Cardiac Center
RECRUITINGSan Diego, California, 92123, United States
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Shady Grove Adventist Hospital
RECRUITINGRockville, Maryland, 20850, United States
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Sisters of Charity Hospital
RECRUITINGBuffalo, New York, 14214, United States
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South Oklahoma Heart Research, LLC
RECRUITINGOklahoma City, Oklahoma, 73135, United States
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Stern Cardiovascular
RECRUITINGSouthaven, Mississippi, 38671, United States
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Stern Cardiovascular Center
RECRUITINGGermantown, Tennessee, 38138, United States
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TPMG Clinical Research
RECRUITINGNewport News, Virginia, 23606, United States
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Tampa Cardiovascular Interventions and Research
RECRUITINGTampa, Florida, 33614, United States
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Texas Cardiology Associates of Houston
RECRUITINGKingwood, Texas, 77339, United States
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The Heart Medical Group
RECRUITINGVan Nuys, California, 91406, United States
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TidalHealth Peninsula Regional
RECRUITINGSalisbury, Maryland, 21804, United States
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TriStar Centennial Medical Center
RECRUITINGNashville, Tennessee, 37203, United States
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Trinity Medical WNY, PC
RECRUITINGBuffalo, New York, 14214, United States
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Tulane School of Medicine
RECRUITINGNew Orleans, Louisiana, 70112, United States
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UMH-Sparrow Clinical Research Institute
RECRUITINGLansing, Michigan, 48912, United States
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Valley Clinical Trials
WITHDRAWNCovina, California, 91723, United States
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Valley Clinical Trials, LLC - Flourish Research
RECRUITINGNorthridge, California, 91325, United States
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Viva Heart and Vein
RECRUITINGTomball, Texas, 77375, United States
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WellSpan Heart and Vascular Research
RECRUITINGYork, Pennsylvania, 17403, United States
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Wellspan Chambersburg Hospital
RECRUITINGChambersburg, Pennsylvania, 17201, United States
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