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Twice-Yearly shot aims to cut heart attacks and amputations

NCT ID NCT06909565

Recruiting now Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests whether inclisiran, a twice-yearly injection that lowers cholesterol, can prevent major heart and limb events in 6,000 people who recently had artery-opening procedures. Participants receive either inclisiran or a placebo shot at the start, at 90 days, and every 6 months. The goal is to see if it reduces heart-related deaths, heart attacks, strokes, and serious limb problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Inclisiran (a twice-yearly injection to lower cholesterol)

What this could lead to

If it works, this could provide a convenient, long-acting option to reduce heart attacks, strokes, and limb complications in high-risk patients after artery procedures.

What could go wrong

This is a large phase 4 trial, but inclisiran is already approved for cholesterol lowering; the main uncertainty is whether it will significantly reduce these specific events beyond standard care. Risks include injection site reactions and possible muscle pain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder coronary artery disorder Hypercholesterolemia peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERCUTANEOUS CORONARY INTERVENTION PERIPHERAL ENDOVASCULAR INTERVENTION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Advanced Cardiovascular LLC

    RECRUITING

    Alexander City, Alabama, 35010, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Advanced Heart Care LLC

    RECRUITING

    Bridgewater, New Jersey, 08807, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Advanced Heart and Vascular Institute Of Hunterdon

    RECRUITING

    Flemington, New Jersey, 08822, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Amarillo Heart Clinical Research Institute, Inc.

    RECRUITING

    Amarillo, Texas, 79124, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • AnMed Health Medical Center

    RECRUITING

    Anderson, South Carolina, 29621, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Apex Research Foundation, LLC

    RECRUITING

    Jackson, Tennessee, 38301, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Arkansas Cardiology

    RECRUITING

    Little Rock, Arkansas, 72205, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Arrow Clinical Trails

    RECRUITING

    Daytona Beach, Florida, 32117, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Asheville Cardiology Associates Research Department

    RECRUITING

    Asheville, North Carolina, 28803, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Aspirus Saint Luke's Hospital

    RECRUITING

    Duluth, Minnesota, 55805, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Atlanta Heart Specialists LLC

    RECRUITING

    Tucker, Georgia, 30084, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • AtlantiCare Regional Medical Center

    RECRUITING

    Pomona, New Jersey, 08240, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Aultman Hospital

    RECRUITING

    Canton, Ohio, 44710, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Austin Heart

    RECRUITING

    Austin, Texas, 78705, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Austin Heart

    RECRUITING

    San Marcos, Texas, 78666, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Austin Heart PLLC

    RECRUITING

    Round Rock, Texas, 78681, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • BayCare Medical Group

    RECRUITING

    Clearwater, Florida, 33756, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Bridgeport Hospital

    RECRUITING

    Bridgeport, Connecticut, 06610, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Bryan Heart

    RECRUITING

    Lincoln, Nebraska, 68506, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • CHI Health Nebraska Heart

    RECRUITING

    Grand Island, Nebraska, 68803, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHI Health Nebraska Heart

    RECRUITING

    Lincoln, Nebraska, 68526, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Capital Area Research LLC

    RECRUITING

    Camp Hill, Pennsylvania, 17011, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Capital Cardiology Associates

    RECRUITING

    Albany, New York, 12211, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Capitol Cardiology Associates PA

    RECRUITING

    Lanham, Maryland, 20706, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Cardiology Associates Research Group

    RECRUITING

    Jonesboro, Arkansas, 72401, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cardiology Associates of Fairfield County

    RECRUITING

    Stamford, Connecticut, 06305, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cardiology Associates of North Mississippi

    RECRUITING

    Tupelo, Mississippi, 38801, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Cardiology Associates of West Reading

    RECRUITING

    West Reading, Pennsylvania, 19611, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cardiology, PC

    RECRUITING

    Birmingham, Alabama, 35211, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cardiovascular Associates of the Delaware Valley

    RECRUITING

    Elmer, New Jersey, 08318, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cardiovascular Associates of the Delaware Valley

    RECRUITING

    Haddon Heights, New Jersey, 08035, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Cardiovascular Associates of the Delaware Valley

    RECRUITING

    Sewell, New Jersey, 08080, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cardiovascular Institute of Northwest Florida

    RECRUITING

    Panama City, Florida, 32405, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cardiovascular Institute of San Diego

    RECRUITING

    Chula Vista, California, 91911, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Cardiovascular Solutions, LLC

    RECRUITING

    Shreveport, Louisiana, 71103, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Charlotte Heart & Vascular Center, PA

    RECRUITING

    Port Charlotte, Florida, 33948, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Chippenham Hospital

    RECRUITING

    Richmond, Virginia, 23225, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Clearwater Cardiovascular Consultants

    RECRUITING

    Clearwater, Florida, 33756, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Clearwater Cardiovascular Consultants

    RECRUITING

    Safety Harbor, Florida, 34695, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Clearwater Cardiovascular and Interventional Consultants- Bardmoor

    RECRUITING

    Largo, Florida, 33777, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Dartmouth-Hitchcock Medical Center

    RECRUITING

    Lebanon, New Hampshire, 03756, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Duke Cardiology

    RECRUITING

    Morrisville, North Carolina, 27560, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Essentia Health-SMMC

    RECRUITING

    Duluth, Minnesota, 55805, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • FOMAT - West Coast Research Center

    RECRUITING

    Ventura, California, 93030, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Genesis HealthCare System

    RECRUITING

    Zanesville, Ohio, 43701, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Grace Research, LLC

    RECRUITING

    Bossier City, Louisiana, 71111, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Healthy Heart Cardiology at Rochester Hills (Advanced Cardiology Associates

    RECRUITING

    Rochester Hills, Michigan, 48307, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Heart Center Research, LLC

    RECRUITING

    Huntsville, Alabama, 35801, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Heart House Research Foundation LLC

    RECRUITING

    Springfield, Ohio, 45505, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Heart Institute of East Texas

    RECRUITING

    Lufkin, Texas, 75904, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hudson Valley Cardiovascular Practice PC

    RECRUITING

    Poughkeepsie, New York, 12601, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Inpatient Research Clinic, LLC

    RECRUITING

    Miami Lakes, Florida, 33014, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Interventional Cardiology Medical Group

    RECRUITING

    West Hills, California, 91307, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Iowa Heart Center

    RECRUITING

    West Des Moines, Iowa, 50266, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • JAVARA Inc, - Mankato Clinic

    RECRUITING

    Mankato, Minnesota, 56001, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Jadestone Clinical Research, LLC

    RECRUITING

    Silver Spring, Maryland, 20904, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Javara Inc.

    RECRUITING

    Fayetteville, North Carolina, 28304, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Javara inc.

    RECRUITING

    Conroe, Texas, 77384, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Javara, Inc.

    RECRUITING

    Peachtree City, Georgia, 30269, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Louisiana Heart Center

    RECRUITING

    Covington, Louisiana, 70433, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

    RECRUITING

    Torrance, California, 90502, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Mecklenburg Heart Specialists

    RECRUITING

    Charlotte, North Carolina, 28207, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Methodist Physicians Clinic Heart Consultants

    RECRUITING

    Omaha, Nebraska, 68114, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Midwest Cardiovascular Research and Education Foundation

    RECRUITING

    Elkhart, Indiana, 46514, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Midwest Heart and Vascular Specialists

    RECRUITING

    Overland Park, Kansas, 66211, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Monroe Research LLC

    RECRUITING

    West Monroe, Louisiana, 71291, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Mount Sinai School of Medicine

    RECRUITING

    New York, New York, 10029, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • MultiCare Institute for Research and Innovation

    RECRUITING

    Puyallup, Washington, 98372, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • MultiCare Institute for Research and Innovation

    RECRUITING

    Tacoma, Washington, 98405, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • MyMichigan Medical Center Midland

    RECRUITING

    Midland, Michigan, 48670, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Northeast Georgia Heart Center, PC

    RECRUITING

    Gainesville, Georgia, 30501, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Northern Light Eastern Maine Medical Center

    RECRUITING

    Bangor, Maine, 04401, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Northwest Houston Heart Center

    RECRUITING

    Tomball, Texas, 77375, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Novant Health Clinical Research/Heart & Vascular Institute

    RECRUITING

    Charlotte, North Carolina, 28204, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Novant Health Forsyth Medical Center

    RECRUITING

    Winston-Salem, North Carolina, 27103, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Nuvance Health- Danbury Hospital

    RECRUITING

    Danbury, Connecticut, 06810, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Pacific Oaks Medical Group

    RECRUITING

    Beverly Hills, California, 90211, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Penn Lancaster General Health Research Institute

    RECRUITING

    Lancaster, Pennsylvania, 17602, United States

    Contact Email: •••••@•••••

    Contact

  • PharmaTex Research

    RECRUITING

    Amarillo, Texas, 79106, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Pioneer Clinical Studies

    RECRUITING

    Coral Gables, Florida, 33134, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Radin Cardiovascular Medical Group, Inc

    RECRUITING

    Newport Beach, California, 92663, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Reid Physician Associates

    RECRUITING

    Richmond, Indiana, 47374, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Research Integrity, LLC

    RECRUITING

    Owensboro, Kentucky, 42303, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Richmond University Medical Center

    RECRUITING

    Staten Island, New York, 10310, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Riverside Community Hospital

    RECRUITING

    Riverside, California, 92501, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • San Diego Cardiac Center

    RECRUITING

    San Diego, California, 92123, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Shady Grove Adventist Hospital

    RECRUITING

    Rockville, Maryland, 20850, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sisters of Charity Hospital

    RECRUITING

    Buffalo, New York, 14214, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • South Oklahoma Heart Research, LLC

    RECRUITING

    Oklahoma City, Oklahoma, 73135, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Stern Cardiovascular

    RECRUITING

    Southaven, Mississippi, 38671, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Stern Cardiovascular Center

    RECRUITING

    Germantown, Tennessee, 38138, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • TPMG Clinical Research

    RECRUITING

    Newport News, Virginia, 23606, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Tampa Cardiovascular Interventions and Research

    RECRUITING

    Tampa, Florida, 33614, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Texas Cardiology Associates of Houston

    RECRUITING

    Kingwood, Texas, 77339, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • The Heart Medical Group

    RECRUITING

    Van Nuys, California, 91406, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • The Jackson Clinic, PA

    RECRUITING

    Jackson, Tennessee, 38305, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • TidalHealth Peninsula Regional

    RECRUITING

    Salisbury, Maryland, 21804, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • TriStar Centennial Medical Center

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Trinity Medical WNY, PC

    RECRUITING

    Buffalo, New York, 14214, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Tulane School of Medicine

    RECRUITING

    New Orleans, Louisiana, 70112, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UMH-Sparrow Clinical Research Institute

    RECRUITING

    Lansing, Michigan, 48912, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Valley Clinical Trials

    WITHDRAWN

    Covina, California, 91723, United States

  • Valley Clinical Trials, LLC - Flourish Research

    RECRUITING

    Northridge, California, 91325, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Viva Heart and Vein

    RECRUITING

    Tomball, Texas, 77375, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • WellSpan Heart and Vascular Research

    RECRUITING

    York, Pennsylvania, 17403, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Wellspan Chambersburg Hospital

    RECRUITING

    Chambersburg, Pennsylvania, 17201, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Winchester Cardiology and Vascular Medicine

    RECRUITING

    Winchester, Virginia, 22601, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••