New study aims to make drugs safer for sick kids

NCT ID NCT05055830

Recruiting now Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how certain drugs behave in the bodies of critically ill children in the heart ICU. Researchers will collect leftover blood samples from routine care to measure drug levels. The goal is to create better dosing guidelines for drugs like methadone, caffeine, acetaminophen, and milrinone. No new drugs are being tested—just improving how we use existing ones.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Methadone, Caffeine, Acetaminophen, Milrinone
What this could lead to: If successful, this could lead to safer, more effective dosing guidelines for commonly used drugs in critically ill children.
What could go wrong: This is an observational study, not a treatment trial. It won't directly benefit participants and may not change practice if results are unclear.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CARDIAC DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Critical Illness heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC DISEASE CHILDREN, ADULT CRITICALLY ILL

Contacts and locations

Locations

Duke University Medical Center
RECRUITING

Durham, North Carolina, 27705, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.