CARDIAC DISEASE

This study is testing whether two drugs, colchicine (an anti-inflammatory) and ticagrelor (a blood thinner), can reduce the risk of another stroke, heart attack, or related death in people who have already had an ischemic stroke. About 2,800 high-risk participants will take these…

This study tests whether giving heparin (a blood thinner) during heart catheterization through the wrist can prevent the wrist artery from closing up afterward. About 1,600 adults will be randomly assigned to receive no heparin, a low dose, or a high dose. The main goal is to see…

This study compares two treatments for bleeding after heart surgery: FEIBA (a drug that helps blood clot) versus fresh frozen plasma (standard care). About 140 adults having non-emergency heart surgery will be enrolled. The goal is to see if FEIBA reduces the need for blood trans…

This study looks at 150 women having heart bypass surgery to see which type of graft—a vein from the leg or an artery from the arm—works better for the second most important heart artery. The goal is to find out which graft stays open longer and causes fewer problems. Participant…

This study tests whether colchicine, a common anti-inflammatory drug, can reduce organ damage after heart surgery. About 768 adults aged 50-80 having planned heart surgery will receive colchicine or a placebo. Researchers will measure heart, lung, and kidney injuries, as well as …

This study is testing a new way to pace the heart called left bundle branch area pacing (LBBAP) in 200 people with conditions like slow heartbeat, heart failure, or atrial fibrillation. The goal is to see if this method is safe and works better than standard pacing over 6 months.…

This study tests a device called Efferon LPS that filters the blood during and shortly after heart surgery. The goal is to see if it can reduce the risk of multiple organ dysfunction syndrome, a serious complication where several organs start to fail. About 60 adults having heart…

This study is developing a computer program that can listen to a newborn's heartbeat using a digital stethoscope and tell if it sounds normal or not. The goal is to catch serious heart problems early, reduce false alarms, and lower healthcare costs. Researchers will record heart …

This study tests whether a rectus sheath block, a type of nerve block, can reduce pain and the need for opioid painkillers after heart surgery. About 75 adults having heart procedures with chest tubes will be randomly assigned to receive the block or not. Researchers will measure…

This study is a registry that collects information on the safety and performance of Boston Scientific heart devices, such as pacemakers and ablation tools, in up to 12,500 people. It does not test a new treatment or drug. Instead, it follows patients over time to track complicati…

This study looks at how medicines behave in the bodies of up to 2,000 critically ill children under 21 in the heart intensive care unit. Researchers collect leftover blood samples and medical data to better understand drug dosing and safety. No new drugs are given—only standard c…

This study is testing whether using artificial intelligence (AI) during heart MRI scans can make the process better for patients. Researchers will compare AI-assisted scans to standard scans in 50 adults with heart disease. They will measure patient satisfaction, total scan time,…

This study looks at how the brain, nervous system, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, heart rate control, and blood flow to see how these systems work together. The goal is to better understand why some people de…

This study looks at older adults (60+) who need surgery for a broken hip after an injury. Researchers want to see if a person's heart health and a special frailty score can help predict who does well after surgery. The goal is to collect five years of data to improve care for thi…