CARDIAC DISEASE

This study is testing a new type of heart pacing lead that is placed in the left bundle branch area, a key part of the heart's electrical system. The goal is to see if this approach is safe and works better than standard pacing for people with bradycardia (slow heart rate) or hea…

This study tests a device called Efferon LPS that filters harmful substances from the blood during and after heart surgery. The goal is to see if it can reduce the risk of multiple organ failure, a serious complication. Researchers will enroll 60 adults having heart surgery with …

This study compares two treatments for bleeding after heart surgery: FEIBA (a special clotting medicine) and fresh frozen plasma (standard care). About 140 adults having non-emergency heart surgery will be enrolled. The goal is to see if FEIBA reduces the need for blood transfusi…

This study tests whether giving heparin (a blood thinner) during heart catheterization through the wrist can prevent the radial artery from becoming blocked afterward. About 1,600 patients will be randomly assigned to receive no anticoagulant, a low dose, or a high dose of hepari…

This study is for women under 75 who need heart bypass surgery for three blocked arteries. It compares two types of grafts for the second most important artery: a leg vein harvested with a special 'no-touch' technique versus a wrist artery. The goal is to see which graft stays op…

This study tests whether the anti-inflammatory drug colchicine can reduce organ damage after heart surgery. About 768 adults aged 50-80 having planned heart surgery will take either colchicine or a placebo before and after their operation. Researchers will track complications lik…

This phase 3 trial is testing whether two drugs—colchicine (used for gout) and ticagrelor (a blood thinner)—can prevent future strokes, heart attacks, and other vascular events in people who have already had a stroke. About 2,800 high-risk participants will be enrolled. The goal …

This study is developing a computer program that can analyze heart sounds recorded with a digital stethoscope to tell if a newborn's heart is healthy or not. Researchers will record heart sounds from 1,000 babies under 30 days old and use those recordings to train and test the pr…

This study tests a 6-session program called BE-FIT that helps cardiac rehabilitation patients reduce anxiety about exercise. The program uses gradual exposure to feared sensations, prevents safety behaviors, and uses activity monitors for feedback. Researchers will enroll 146 adu…

This study tests whether a rectus sheath block, a type of nerve block using local anesthetic, can reduce pain and the need for opioid painkillers after cardiac surgery. Researchers will compare opioid use and pain scores in 75 adults who receive the block versus those who do not.…

This registry is a large-scale effort to monitor the safety and performance of Boston Scientific cardiac devices, including pacemakers and ablation tools, in 12,500 patients. It collects data from routine procedures and follow-ups to see how well the devices work and if any compl…

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The model alerts doctors when a child may need a palliative care consultation. Researchers will compare outcomes before and after the model is used, involving …

This study looks at how the brain, nerves, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, blood flow, and heart reflexes to better understand the link between heart disease and depression. The goal is to develop new tools fo…

This study looks back at medical records of 100 older adults (60+) who had hip surgery after an injury. Researchers want to see if a simple frailty score or standard heart tests better predict who will have complications or die after surgery. The goal is to find better ways to as…

This study compares AI-assisted cardiac MRI to standard MRI in 50 adults with heart disease. Participants are randomly assigned to one of the two scan methods. Researchers will measure patient satisfaction and total scan time to see if AI makes the experience better or faster.

This study looks at how certain drugs behave in the bodies of critically ill children in the heart ICU. Researchers will collect leftover blood samples from routine care to measure drug levels. The goal is to create better dosing guidelines for drugs like methadone, caffeine, ace…