Can a simple drug combo stop heart disease before it starts?
NCT ID NCT07232069
First seen Nov 18, 2025 · Last updated Jun 22, 2026 · Updated 31 times
Summary
This study will screen 1,500 people with early signs of heart disease (plaque in arteries) to see if two common drugs—rosuvastatin and colchicine—can reduce or stabilize that plaque over two years. Participants will take pills daily and get heart-healthy lifestyle advice. The goal is to find out if early treatment can prevent heart disease from getting worse.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rosuvastatin (a cholesterol-lowering statin) and colchicine (an anti-inflammatory drug)
What this could lead to
If it works, this could show that early treatment with common drugs can slow or stabilize plaque buildup in heart arteries, potentially preventing future heart attacks.
What could go wrong
This is a large Phase 3 trial, but it's still testing an idea—early treatment may not work better than lifestyle advice alone. Side effects from the drugs, like muscle pain or stomach issues, could also limit their use.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.