Can a simple drug combo stop heart disease before it starts?

NCT ID NCT07232069

Recruiting now Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 9 times

Summary

This study will screen 1,500 people with early signs of heart disease (plaque in arteries) to see if two common drugs—rosuvastatin and colchicine—can reduce or stabilize that plaque over two years. Participants will take pills daily and get heart-healthy lifestyle advice. The goal is to find out if early treatment can prevent heart disease from getting worse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Rosuvastatin (a cholesterol-lowering statin) and colchicine (an anti-inflammatory drug)
What this could lead to: If it works, this could show that early treatment with common drugs can slow or stabilize plaque buildup in heart arteries, potentially preventing future heart attacks.
What could go wrong: This is a large Phase 3 trial, but it's still testing an idea—early treatment may not work better than lifestyle advice alone. Side effects from the drugs, like muscle pain or stomach issues, could also limit their use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE PROGRESSION CORONARY ARTERY DISEASE RISK FACTORS MULTIPLE PREMATURE ATHEROSCLEROSIS PREVENTION & CONTROL

Contacts and locations

Locations

Cardiology Associates
NOT_YET_RECRUITING

Mobile, Alabama, 36608, United States
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
Essentia Health
NOT_YET_RECRUITING

Duluth, Minnesota, 55805, United States
Houston Methodist Hospital
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Inova Health System
NOT_YET_RECRUITING

Fairfax, Virginia, 22031, United States
Johns Hopkins University
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
RECRUITING

Los Angeles, California, 90502, United States
Marshfield Clinical Research Institute
NOT_YET_RECRUITING

Marshfield, Wisconsin, 54449, United States
Massachusetts General Hospital Brigham
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Medical University of South Carolina (MUSC)
NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States
New York University Langone
NOT_YET_RECRUITING

New York, New York, 10016, United States
Northern Westchester Hospital
NOT_YET_RECRUITING

Mount Kisco, New York, 10549, United States
Oregon Health and Sciences University
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Thomas Jefferson University
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35205, United States
University of California, Los Angeles
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
University of Chicago
NOT_YET_RECRUITING

Chicago, Illinois, 60637, United States
University of Pittsburgh Medical Center
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Virginia (UVA)
NOT_YET_RECRUITING

Charlottesville, Virginia, 22903, United States
Vanderbilt University
NOT_YET_RECRUITING

Nashville, Tennessee, 37203, United States
Wake Forest University, Advocate Health
NOT_YET_RECRUITING

Winston-Salem, North Carolina, 27157, United States
Weill Cornell Medicine
RECRUITING

New York, New York, 10021, United States
Wellstar Kennestone Hospital
RECRUITING

Hiram, Georgia, 30141, United States

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