Can Extra-Strength statins stop heart attacks before they start?
NCT ID NCT05462262
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether stronger cholesterol-lowering drugs (atorvastatin plus ezetimibe) can slow the growth of artery plaque and reduce heart attacks, strokes, and other heart problems in adults aged 40–75 who have early plaque but are only at low-to-moderate risk. About 2,900 participants will be randomly assigned to either intensive or standard cholesterol treatment and followed for several years. The goal is to see if a more aggressive approach prevents heart events better than current standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
atorvastatin and ezetimibe
What this could lead to
If successful, this could show that more aggressive cholesterol lowering helps prevent heart attacks and strokes in people with early plaque buildup.
What could go wrong
This is an open-label trial, so results may be biased. The benefit may be small, and intensive therapy can cause muscle pain or liver issues.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CORONARY ARTERY DISEASE PROGRESSION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Fuwai Hospital
Beijing, Beijing Municipality, China