Could preterm babies safely get fewer antibiotics?

NCT ID NCT07610486

Recruiting now Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 06, 2026 · Updated 6 times

Summary

This study looks at whether preterm infants in the NICU can safely stop taking the antibiotic ampicillin after 24 to 36 hours instead of the usual 48 hours. Researchers will measure drug levels in the blood and monitor the babies for any problems. The goal is to see if a shorter course still provides enough protection against infection while reducing unnecessary medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ampicillin
What this could lead to: If successful, this could show that a shorter course of antibiotics is safe and effective for preterm infants, potentially reducing unnecessary antibiotic exposure.
What could go wrong: This is an early-phase trial with only 60 infants, so results may not apply to all preterm babies. There is a risk that shorter treatment might not prevent infection.

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Conditions

The condition(s) this trial relates to.

neonatal sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPICILLIN EARLY ONSET SEPSIS NICU PRETERM NEONATES SAFETY AND PHARMACOKINETICS

Contacts and locations

Locations

Duke Health Neonatal Intensive Care Unit
RECRUITING

Durham, North Carolina, 27705, United States

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