Duke University

This is an early-stage study testing the safety and immune response of a new vaccine designed to protect against multiple coronaviruses, not just the one that causes COVID-19. The study will enroll 51 healthy adults to receive two doses of the experimental vaccine at different st…

This study is creating a registry to track patients with eye melanoma who receive radiation plaque therapy. Researchers want to see if using lower radiation doses can still effectively control the tumor while causing fewer side effects like vision problems. The study follows 42 p…

This study is testing whether a faster schedule of non-invasive brain stimulation can improve hand control and writing in people with focal hand dystonia, a condition causing involuntary muscle contractions in the hand. Researchers will give participants four magnetic stimulation…

This study aims to see if an intensive, therapist-led rehabilitation program delivered at home is as effective for recovery as traditional inpatient rehab after a stroke. Researchers will observe about 500 patients who choose either the home-based program or a rehab facility, com…

This study is testing whether adding a drug called alirocumab to standard pre-surgery treatment (chemotherapy plus an immunotherapy drug, cemiplimab) can help the immune system better recognize and attack early-stage non-small cell lung cancer. About 126 patients with stage 1B-3A…

This study is testing whether a virtual heart failure care program can help people recently hospitalized for heart failure. The program provides education, monitors symptoms remotely, and helps adjust medications quickly. Researchers want to see if this approach reduces hospital …

This study is testing if a single dose of chemotherapy delivered directly to the liver artery is safe and practical for people with pancreatic cancer who are scheduled for surgery. The goal is to see if this extra step, given before the standard surgery and chemo, can help contro…

This study is testing whether combining two existing drugs—alirocumab and cemiplimab—can help control advanced lung cancer that has gotten worse after initial immunotherapy. It will involve about 60 adults whose cancer has spread and who have already tried and stopped responding …

This study is testing a new way to care for older adults who receive dialysis. It adds a specialized geriatric team to the dialysis clinic to help manage common problems like memory issues, falls, and medication side effects. The goal is to see if this integrated approach is prac…

This study aims to improve deep brain stimulation (DBS) for Parkinson's disease by using detailed maps of the brain's wiring. Researchers will test if targeting specific brain pathways can better control tremor while avoiding side effects like involuntary movements. The study inv…

This study is testing if a special PET scan taken partway through radiation treatment can help doctors see how the cancer is responding. If the scan shows the tumor is shrinking, doctors could adjust the remaining radiation to better target the cancer and potentially spare more h…

This study is testing whether a non-invasive brain stimulation technique can help people who want to cut back on heavy cannabis use. Researchers will use a device called TMS to target brain areas linked to cravings and see if it reduces both the urge to use cannabis and actual us…

This study tests a new program designed to improve teamwork between cancer specialists and primary care doctors (PCPs) for patients who have both cancer and a heart-related condition like high blood pressure or diabetes. The goal is to see if better coordination helps manage the …

This study aimed to see if time-restricted eating (limiting food to a 10-hour daily window) could improve outcomes for people with advanced head & neck or kidney cancer receiving immunotherapy. Researchers wanted to learn if this eating pattern changes gut bacteria and the body's…

This study is testing a structured plan for delivering nutrition to patients in the intensive care unit (ICU) after major abdominal surgery or trauma. The goal is to see if this careful feeding approach, which uses a device to measure calorie needs and includes tube feeding and s…

This study is testing a new, faster way to give radiation to women with early-stage breast cancer. Instead of multiple weeks of treatment, it gives one strong dose of radiation before surgery. The main goal is to see if this single dose leads to good cosmetic results while still …

This study is testing a new approach for treating common low back pain. It compares whether patients do better if their first visit is with a physical therapist or chiropractor, instead of their regular doctor. The goal is to see if this leads to less pain, better physical functi…

This study is developing and testing a new support program called mSTARS for people who misuse alcohol and have been hospitalized for a suicide crisis. The program combines therapy during the hospital stay with a smartphone app to use for 30 days after going home, aiming to teach…

This study is testing if a lower dose and smaller area of radiation treatment can work as well as the standard dose for patients with a type of blood cancer called diffuse large B-cell lymphoma. It is for people who have already finished chemotherapy and have a negative PET scan.…

This study is testing whether adding a cholesterol-lowering injection called inclisiran to usual care helps people with heart disease or high risk for it reach their cholesterol goals. It focuses on including diverse participants, such as women and people from racial/ethnic minor…

This early-stage study is testing if a common antidepressant drug, fluoxetine (Prozac), can make a standard chemotherapy drug (temozolomide) more effective at killing recurrent brain tumor cells. The researchers want to see if fluoxetine causes stress inside cancer cells, making …

This study is testing a new, lower-cost eye scanner to see if it can take pictures of the back of the eye (retina) as well as a standard commercial machine. Researchers want to see if this device can detect changes in the retina that might be linked to Alzheimer's disease. They a…

This study is testing a new scoring system called the 5-SENSE score. The goal is to see how well this score can predict the exact spot in the brain where seizures begin, using information from standard pre-surgery tests. If successful, this tool could help doctors decide which pa…

This study is testing a 16-week diet coaching and cooking class program designed to help Black adults at risk for kidney disease eat healthier. The goal is to see if this community-based approach is practical and acceptable to participants. Researchers will measure if the program…

This study aims to find the best way to prevent future falls and fractures in older adults recovering from a broken bone in a nursing facility. It will compare three different remote care models delivered by a nurse consultant and a team. One model focuses on reducing medications…

This study is testing a support program called BETTER for adults with traumatic brain injury (TBI) and their families after they leave the hospital. The program provides education, helps coordinate care, and teaches coping skills over 16 weeks to improve patients' quality of life…

This study is exploring whether playing virtual reality (VR) games can help patients in the intensive care unit (ICU) after heart surgery. Researchers want to see if using VR to encourage arm and hand movements can improve patients' physical activity and mental well-being. The st…

This study is testing whether tailored light therapy or melatonin supplements can help people with Long COVID who are struggling with severe sleep problems like insomnia or daytime sleepiness. It's a Phase 2 trial involving 470 participants across multiple centers. The goal is to…

This study is testing different treatments to help people with Long COVID who get very tired and feel worse after even light exercise. It will enroll 360 participants across multiple centers to see if certain interventions can help them walk longer, do more daily activities, and …

This study aims to find out if patients need to wear a shoulder sling for the typical three weeks after a reverse shoulder replacement surgery. Researchers are comparing two groups: one wears a sling for three weeks, and the other wears it for only three days. They will track 100…

This study is testing whether a nutritional drink containing ketones can help people with a specific type of heart failure (HFpEF) exercise more easily and improve their heart function. About 20 participants will try the ketone drink and a placebo drink for 8 weeks each to see wh…

This study is developing and testing a new program to help women with sexual problems after pelvic radiation for cancer. The program combines physical therapy exercises with coping skills training to improve comfort and function. Researchers are working with a small group of canc…

This study is testing whether a ketone drink can help people with heart failure exercise longer and feel less tired and short of breath. Researchers will give the drink to 25 participants with reduced heart pumping ability and measure how it affects their exercise capacity and he…

This study is testing whether a simple technique called remote ischemic conditioning (RIC)—briefly squeezing and releasing blood flow in the arm with a cuff—is practical and acceptable when added to exercise for adults over 65 who have trouble with mobility. The main goal is to s…

This study is testing a video-based therapy program designed to help people with advanced cancer manage their pain. The program teaches coping skills and focuses on helping patients find meaning and purpose despite their illness. About 210 adults with advanced solid tumors and si…

This study is testing different treatments to help people with Long COVID who struggle with severe sleep problems like extreme daytime sleepiness and insomnia. About 361 participants will be assigned to receive either an active treatment or a placebo based on their specific sleep…

This study aims to collect and analyze fluid from the shoulder, hip, and knee joints to find biological markers that signal the start or progression of osteoarthritis. Researchers will enroll 149 adults who are already scheduled for joint surgery to build a collection of these fl…

This study is creating a network of medical centers to collect and share information on how children with cleft lip and/or palate are treated and how they do over time. The goal is to help doctors compare results and find ways to improve care for speech, hearing, dental health, a…

This study aimed to collect blood and tumor tissue samples from people with stomach or esophageal cancer. Researchers wanted to analyze these samples to understand why some cancers stop responding to immunotherapy drugs. The study was withdrawn before any participants were enroll…

This study aims to understand how tumors in a specific part of the brain called the cerebellum affect a person's thinking skills and coordination before and after surgery. Researchers will compare 66 adults with tumors in the cerebellum to those with tumors in other brain areas. …

This study is testing whether a special type of MRI scan, which uses inhaled xenon gas, can help doctors see how well the lungs are working in people with Idiopathic Pulmonary Fibrosis (IPF). Researchers want to see if this scan can detect changes in lung function over time as pa…

This study aims to gather information about spine tumors and other spine conditions to help guide better treatment strategies in the future. It involves 900 adults with spine tumors, infections, injuries, or instability, as well as some people having spine surgery for other reaso…

This study aimed to learn how the bodies of obese adults and children with arthritis process the drug etanercept. Researchers wanted to measure drug levels in the blood and see how body weight influences the drug's effectiveness, with the goal of finding the right dose. The study…

This study aims to understand how different treatments for advanced kidney cancer affect patients' quality of life and symptoms in everyday practice. It will follow about 470 patients already receiving standard care, collecting information through questionnaires and medical recor…

This study aims to learn more about the early signs and symptoms of late-onset Pompe disease in babies and young children who are diagnosed through newborn screening. Researchers will closely monitor 20 children over several years to understand how the disease develops and to hel…

This study is testing a training program for doctors to improve pregnancy planning and contraception care for women with lupus. Researchers are adapting a program that worked at Duke University to see if it fits well at the University of Chicago Medical Center, which serves many …

This study aims to gather information to help design a new type of immunotherapy for glioblastoma, a serious brain cancer. Researchers will track 40 patients to understand how and why their cancer-fighting immune cells get trapped in the bone marrow, away from the tumor. The goal…

This study aims to understand the out-of-pocket costs and financial strain experienced by people undergoing treatment for head and neck cancer. Researchers will follow 60 patients to see how these costs impact their quality of life and influence their treatment decisions. The stu…

This study looks at how cancer doctors use telehealth (video or phone visits) instead of in-person appointments during COVID-19. Researchers want to understand doctors' experiences with telehealth and whether it affects how often patients need emergency care. They'll compare resu…

This study aimed to see how consistently MRI scans could measure changes in a specific type of slow-growing brain tumor (low-grade glioma) in patients taking the drug ivosidenib. It planned to enroll 40 adults who were already scheduled for a routine MRI as part of their care. Th…

This study aims to test safety procedures for astronauts to prevent decompression sickness, commonly known as 'the bends,' during spacewalks. Healthy volunteers will breathe pure oxygen and then experience low-pressure conditions in a special chamber while performing tasks. Resea…

This study aims to understand what factors matter most to patients when choosing treatments for common bone and joint conditions like arthritis and fractures. Researchers are asking over 2,300 patients to complete surveys about how factors like pain, recovery time, cost, and surg…

This study is testing a special type of MRI scan to see if it can detect changes in lung scarring. It will enroll 60 adults with progressive lung scarring who are starting or considering anti-scarring medication. Participants will have the MRI scan before starting treatment and a…

This study is creating a large registry of people living in the United States who are interested in participating in future health research. It aims to build a community of 20,000 participants by collecting basic information and survey responses. The data will help researchers co…

This study aims to find better ways for doctors to talk with seriously ill patients about their end-of-life care preferences. It will test different communication strategies with 5,000 Duke Health patients who have conditions like cancer, heart failure, COPD, or dementia. The goa…

This study aims to learn how the immune system changes when patients with advanced kidney or bladder cancer receive immunotherapy drugs. Researchers will collect blood samples from about 67 patients before and during treatment to measure different immune cells and cancer cells in…

This study is observing thousands of University of North Carolina alumni over many years to learn if personality traits like hostility and depression are connected to the development of heart disease. It is not testing a treatment; instead, it aims to gather knowledge by tracking…

This study aimed to test whether training obstetric providers to counsel pregnant patients about workplace rights and accommodations would lead to better outcomes. The trial planned to compare trained providers against usual care, measuring how often work-related counseling was d…

This study is testing a new training program to help doctors improve how they talk with, listen to, and partner with their patients. The goal is to see if better communication skills can help manage high blood pressure more effectively. Researchers will enroll 180 participants, i…

This study is creating a large community health registry and sample bank in Cabarrus County and Kannapolis, North Carolina. It aims to enroll 50,000 local residents to provide their health information and biological samples. The collected data will be used as a resource for futur…

This study is testing a new version of a standard balance test for people recovering from ACL knee surgery. Researchers want to see if adding a mental challenge (like reacting to flashing lights) provides better information about how well each leg is recovering. The goal is to us…