New score could spare epilepsy patients from invasive brain probes

NCT ID NCT06138808

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a simple scoring system, called the 5-SENSE score, can accurately predict where seizures begin in the brain. Researchers will test this in 400 people with hard-to-treat epilepsy who are already scheduled for an invasive brain test called SEEG. If the score works well, it may help some patients avoid this risky procedure in the future.

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Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY INTRACTABLE

Contacts and locations

Locations

"Carol Davila" University of Medicine and Pharmacy

Bucharest, Romania
Alfred Health

Melbourne, Australia
Christian Doppler University Hospital Paracelsus Medical University Salzburg and Centre for Cognitive Neuroscience Salzburg

Salzburg, 5020, Austria
Dalhousie Universiry and Hospital

Dalhousie, Nova Scotia, Canada
Danish Epilepsy Centre, Aarhus Universitets Hospital

Aarhus, 8200, Denmark
Department of Clinical Neurosciences chez CHUV; Centre Hospitalier Universitaire Vaudois

Lausanne, Switzerland
Departmet of Neurology, Masaryk University Brno

Brno, Czechia
Duke University Health System

Durham, North Carolina, 27710, United States
Epilepsy Centre, University Hospital Freiburg

Freiburg im Breisgau, Germany
Epilepsy Department University Hospitals of Marseille

Marseille, France
Grenoble Institute of Neurosciences, Centre Hospitalier Universitaire Grenoble Alpes

Grenoble, France
Hospital Universitario y Politecnico La Fe

Valencia, Spain
Mater Health

Brisbane, Australia
Monash University

Melbourne, Victoria, 3800, Australia
Northwestern University

Chicago, Illinois, 60611, United States
Presbyterian-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
University School of Medicine Kyoto

Kyoto, 606-8303, Japan
University of Florida College of Medicine

Gainesville, Florida, 32610, United States
Wester University

London, Ontario, Canada

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