One-Shot radiation before breast cancer surgery shows promise

NCT ID NCT02482376

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This phase II trial tests a single, high-dose radiation treatment given before surgery for early-stage breast cancer. The goal is to see if this approach leads to good or excellent cosmetic results and reduces the need for multiple radiation sessions. About 110 women with small, early breast cancers will receive one focused radiation dose, then undergo standard surgery. Researchers will track cosmetic outcomes and cancer control over three years.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Stereotactic body radiotherapy (SBRT) - a single high-dose radiation beam
What this could lead to
If successful, this could offer a shorter, more convenient radiation option before surgery for early breast cancer, potentially with better cosmetic results and fewer side effects.
What could go wrong
This is a phase II trial with only 110 participants, so results may not apply to all patients. The single high-dose radiation could cause unexpected tissue damage or poor cosmetic outcomes in some cases.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Duke Cancer Center

    Durham, North Carolina, 27710, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.