Mid-treatment PET scan may allow safer, lower radiation for throat cancer
NCT ID NCT04667585
First seen Mar 07, 2026 · Last updated Jun 23, 2026 · Updated 15 times
Summary
This study is testing whether a PET scan taken partway through radiation treatment can identify patients with HPV-related throat cancer who can safely receive a lower dose of radiation. The goal is to reduce side effects while still controlling the cancer. About 120 adults with stage I-III oropharynx cancer are being enrolled.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Duke Raleigh Hospital
Raleigh, North Carolina, 27609, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
reduced dose of radiation therapy
What this could lead to
If successful, this could allow many patients with HPV-related throat cancer to receive less radiation, reducing long-term side effects without compromising cancer control.
What could go wrong
This is a single-arm, non-randomized study with 120 participants, so results may not apply broadly. Lowering radiation might increase the risk of cancer recurrence in some patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.