OROPHARYNX CANCER

This study tests whether giving radiation to fewer lymph nodes in the neck, based on each patient's cancer spread, can reduce side effects without increasing the risk of cancer returning. About 120 adults with newly diagnosed oropharynx cancer will receive standard (chemo)radioth…

This study tests a new immunotherapy for people with advanced HPV-related cancers (cervical, throat, anal, and others). Participants receive specially engineered immune cells designed to attack HPV-infected tumor cells, along with chemotherapy and a drug to boost cell activity. T…

This study tests whether taking three oral drugs (methotrexate, erlotinib, and celecoxib) together is safe and practical for patients with head and neck cancer that has come back or spread. It enrolls 25 adults in the rural Midwest. The goal is to see if this all-pill regimen can…

This study looks at whether people with HPV-positive throat cancer who had surgery can safely receive a lower radiation dose to a smaller area (just the neck, not the original tumor site). The goal is to keep the cancer from coming back while reducing side effects. About 30 adult…

This study tests whether giving a single dose of specially engineered immune cells (E7 TCR-T cells) before standard treatment (chemoradiation or surgery) can shrink or eliminate tumors in people with advanced HPV-related cancers. About 15 participants will have their own T cells …

This study looks at whether a simple blood test can tell which throat cancer patients can safely skip radiation after surgery. About 61 people with HPV-related throat cancer will have their blood tested before and after surgery. If the test is negative after surgery and they are …

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink tumors in people with advanced head and neck cancer that has returned or spread after initial treatment. About 40 adults whose cancer worsened after first-line therapy will receive the c…

This study is for people with HPV-related throat cancer who are getting standard chemotherapy and radiation. Researchers want to see if a special PET scan taken during treatment can identify patients who respond well enough to safely receive a lower dose of radiation. The goal is…

This study tests two ideas for people with certain head and neck cancers: using a smaller radiation area to reduce side effects, and adding a drug called ATRA (a form of vitamin A) to help control the disease. About 460 adults will be randomly assigned to standard or smaller radi…

This study is for people with HPV-related throat cancer who have had or will have surgery. Researchers will use a blood test that looks for cancer DNA (HPV ctDNA) to decide if radiation therapy is needed. In one group, patients with no detectable cancer DNA after surgery will ski…

This study is testing a new surgical technique to rebuild parts of the mouth or throat after cancer removal. The new method uses a skin flap from the groin area (external pudendal flap) instead of the usual donor sites, hoping to cause fewer complications. The study will include …

This study aims to find out how many healthy adults over 40 in the Czech Republic have high-risk HPV in their mouth, which can lead to throat cancer. Researchers will test 20,000 volunteers using a simple mouth rinse. The goal is to develop a better, more practical screening meth…

This study tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery, as guidelines recommend. About 532 adults will be assigned to either the navigation program or usual care. The goal is to see if the program red…