Could a ketone drink boost exercise in heart failure patients?

NCT ID NCT06937320

ENROLLING_BY_INVITATION Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether a ketone drink can improve exercise capacity in people with heart failure with preserved ejection fraction (HFpEF). Twenty participants will receive either the ketone drink or a placebo for 8 weeks, then switch. The main goal is to see if the drink helps them exercise more.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketone drink (KetoneIQ)
What this could lead to: If it works, this could point toward a simple dietary supplement to help people with HFpEF exercise more easily.
What could go wrong: This is a small, early-phase study with only 20 participants, so results may not apply widely. The drink may cause digestive discomfort or have no effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans Syndrome diastolic heart failure heart failure Ketosis Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH NORMAL EJECTION FRACTION HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF) HEART FAILURE, DIASTOLIC

Contacts and locations

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Locations

Duke University

Durham, North Carolina, 27710, United States

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