New MRI trick may spot hidden brain tumors without a biopsy

NCT ID NCT04246879

Ongoing Diagnosis Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether an extra MRI scan, taken later than usual, can better tell the difference between a growing tumor and harmless radiation scar in people with brain metastases who have had radiosurgery. Twenty-five adults with solid tumors (except small cell lung cancer or lymphoma) will get the delayed MRI, and results will be checked against a biopsy. If it works, it could spare patients from unnecessary invasive procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could give doctors a more accurate way to tell whether a brain lesion is a returning tumor or harmless scar tissue, reducing unnecessary biopsies.
What could go wrong: This is a small, early study with only 25 participants. The MRI technique may not prove reliable enough for routine use, and results may not apply to all tumor types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES

Contacts and locations

Locations

Duke University Health System

Durham, North Carolina, 27710, United States

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