Can a common antidepressant boost brain tumor treatment?
NCT ID NCT05634707
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase trial tests whether fluoxetine, an FDA-approved antidepressant, can increase stress in cell structures called lysosomes to make the chemotherapy drug temozolomide more effective against recurrent brain tumors. Ten participants with recurrent glioma will receive either fluoxetine plus temozolomide or temozolomide alone before surgery. Researchers will compare tumor samples to see if fluoxetine changes lysosome activity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- fluoxetine and temozolomide
- What this could lead to
- If it works, this could point toward a way to make standard chemotherapy more effective for recurrent brain tumors.
- What could go wrong
- This is a very early, small trial with only 10 participants, so results may not apply broadly. The study focuses on cell changes, not direct patient outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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NYU Langone Health
New York, New York, 10016, United States
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Stanford Cancer Institute
Stanford, California, 94305, United States
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The Preston Robert Tisch Brain Tumor Center at Duke University
Durham, North Carolina, 27710, United States
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UC San Diego Moores Cancer Center
San Diego, California, 90074-1539, United States
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