Nerve zap could unclog heart failure lungs

NCT ID NCT06733012

Recruiting now Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether blocking signals from the splanchnic nerve can reduce congestion and improve exercise ability in people with heart failure. About 54 adults with heart failure and reduced pumping function will receive either a nerve-blocking procedure or a sham procedure. The goal is to see if this approach safely eases symptoms and improves daily function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: catheter-based ablation of the right greater splanchnic nerve
What this could lead to: If it works, this could offer a new way to reduce heart failure symptoms like shortness of breath and fatigue, improving daily life.
What could go wrong: This is an early, small study (54 people) testing safety and effectiveness. The procedure carries risks like bleeding, infection, or nerve damage, and may not work for everyone.

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Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE

Contacts and locations

Locations

Duke
RECRUITING

Durham, North Carolina, 27278, United States

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