New trial tests if early surgery saves lives in aortic dissection
NCT ID NCT06087029
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study is testing whether doing a procedure called TEVAR (a minimally invasive surgery to repair the aorta) along with standard medications is better than medications alone for people with a type of aortic dissection that hasn't caused complications. About 1,100 participants will be randomly assigned to one of the two approaches. The main goal is to see which strategy reduces the chance of death or serious problems like rupture, stroke, or kidney failure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Thoracic endovascular aortic repair (TEVAR) procedure
What this could lead to
If successful, this could establish that early TEVAR plus medical therapy is better than medical therapy alone for preventing death or serious complications in people with uncomplicated type B aortic dissection.
What could go wrong
This is a large, randomized trial, but the intervention (TEVAR) carries risks like stroke, spinal cord injury, or need for further procedures. The results may not apply to all patients with aortic dissection.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Baylor Scott & White Research Institute
RECRUITINGDallas, Texas, 75226, United States
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Baylor Scott & White The Heart Hospital - Plano
RECRUITINGPlano, Texas, 75093, United States
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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CAMC Clinical Trials Center
RECRUITINGCharleston, West Virginia, 25304, United States
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CHUM - Centre hospitalier de l'Universite de Montreal
RECRUITINGMontreal, Quebec, H2X 0C1, Canada
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Cooper University Hospital
RECRUITINGCamden, New Jersey, 08103, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Harrington Heart and Vascular Institute
RECRUITINGCleveland, Ohio, 44106, United States
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Hartford Hospital
RECRUITINGHartford, Connecticut, 06102, United States
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Henry Ford Health System
RECRUITINGDetroit, Michigan, 48202, United States
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Honorhealth
RECRUITINGPhoenix, Arizona, 85020, United States
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Houston Methodist Hospital
RECRUITINGHouston, Texas, 77030, United States
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
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Indiana University Methodist Hospital
RECRUITINGIndianapolis, Indiana, 46202, United States
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21230, United States
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Keck Medical Center of USC
RECRUITINGLos Angeles, California, 90033, United States
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Maimonides Medical Center
WITHDRAWNBrooklyn, New York, 11219, United States
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MaineHealth
RECRUITINGScarborough, Maine, 04101, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic
WITHDRAWNRochester, Minnesota, 55905, United States
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McGill University Medical Center
RECRUITINGMontreal, Quebec, H3A 0G4, Canada
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Memorial Care Long Beach Medical Center
RECRUITINGLong Beach, California, 90806, United States
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Memorial Hospital Central
RECRUITINGColorado Springs, Colorado, 90803, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
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Rutgers UH Vascular Center
RECRUITINGJersey City, New Jersey, 07302, United States
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SUNY Upstate Medical University
RECRUITINGSyracuse, New York, 13120, United States
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Sanger Heart & Vascular Institute
WITHDRAWNCharlotte, North Carolina, 28201, United States
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Sentara Cardiovascular Research Institute
RECRUITINGNorfolk, Virginia, 23507, United States
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Southern Illinois University School of Medicine
RECRUITINGSpringfield, Illinois, 62702, United States
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Spectrum Health and Hospitals and Corewell
RECRUITINGGrand Rapids, Michigan, 49503, United States
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St. Francis Hospital and Heart Center
RECRUITINGRoslyn, New York, 11576, United States
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Stanford University Medical Center
WITHDRAWNStanford, California, 94305, United States
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Stony Brook University Medical Center
RECRUITINGStony Brook, New York, 11794, United States
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Tampa General Hospital
RECRUITINGTampa, Florida, 33606, United States
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The Ohio State University Medical Center
RECRUITINGColumbus, Ohio, 43210, United States
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The University of Chicago
WITHDRAWNChicago, Illinois, 60637, United States
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The University of Texas Health Houston
RECRUITINGHouston, Texas, 77030, United States
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Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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UT Dell Medical School- Ascension
RECRUITINGAustin, Texas, 78712, United States
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UT Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
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University of California
RECRUITINGSan Francisco, California, 94143, United States
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University of California San Diego
WITHDRAWNSan Diego, California, 92110, United States
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University of Colorado Denver
RECRUITINGAurora, Colorado, 80045, United States
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University of Florida Health
RECRUITINGGainesville, Florida, 32608, United States
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Massachusetts Memorial
RECRUITINGWorcester, Massachusetts, 01655, United States
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University of Michigan Health
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
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University of Missouri Health Care
RECRUITINGColumbia, Missouri, 65212, United States
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University of Nebraska Medical Center
WITHDRAWNOmaha, Nebraska, 68198, United States
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University of North Carolina Chapel Hill
WITHDRAWNChapel Hill, North Carolina, 27599, United States
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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University of Rochester Medical Center
RECRUITINGRochester, New York, 14642, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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University of Washington
RECRUITINGSeattle, Washington, 98104, United States
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University of Wisconsin
RECRUITINGMadison, Wisconsin, 53792, United States
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Washington University School of Medicine
WITHDRAWNSt Louis, Missouri, 63110, United States
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Yale University
RECRUITINGNew Haven, Connecticut, 06510, United States
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