New trial tests if early surgery saves lives in aortic dissection

NCT ID NCT06087029

Recruiting now Disease control Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study is testing whether doing a procedure called TEVAR (a minimally invasive surgery to repair the aorta) along with standard medications is better than medications alone for people with a type of aortic dissection that hasn't caused complications. About 1,100 participants will be randomly assigned to one of the two approaches. The main goal is to see which strategy reduces the chance of death or serious problems like rupture, stroke, or kidney failure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Thoracic endovascular aortic repair (TEVAR) procedure
What this could lead to: If successful, this could establish that early TEVAR plus medical therapy is better than medical therapy alone for preventing death or serious complications in people with uncomplicated type B aortic dissection.
What could go wrong: This is a large, randomized trial, but the intervention (TEVAR) carries risks like stroke, spinal cord injury, or need for further procedures. The results may not apply to all patients with aortic dissection.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE B AORTIC DISSECTION

Contacts and locations

Locations

Baylor Scott & White Research Institute
RECRUITING

Dallas, Texas, 75226, United States
Baylor Scott & White The Heart Hospital - Plano
RECRUITING

Plano, Texas, 75093, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CAMC Clinical Trials Center
RECRUITING

Charleston, West Virginia, 25304, United States
CHUM - Centre hospitalier de l'Universite de Montreal
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Cooper University Hospital
RECRUITING

Camden, New Jersey, 08103, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Harrington Heart and Vascular Institute
RECRUITING

Cleveland, Ohio, 44106, United States
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06102, United States
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Honorhealth
RECRUITING

Phoenix, Arizona, 85020, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Indiana University Methodist Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21230, United States
Keck Medical Center of USC
RECRUITING

Los Angeles, California, 90033, United States
Maimonides Medical Center
WITHDRAWN

Brooklyn, New York, 11219, United States
MaineHealth
RECRUITING

Scarborough, Maine, 04101, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
WITHDRAWN

Rochester, Minnesota, 55905, United States
McGill University Medical Center
RECRUITING

Montreal, Quebec, H3A 0G4, Canada
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Care Long Beach Medical Center
RECRUITING

Long Beach, California, 90806, United States
Memorial Hospital Central
RECRUITING

Colorado Springs, Colorado, 90803, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Rutgers UH Vascular Center
RECRUITING

Jersey City, New Jersey, 07302, United States
SUNY Upstate Medical University
RECRUITING

Syracuse, New York, 13120, United States
Sanger Heart & Vascular Institute
WITHDRAWN

Charlotte, North Carolina, 28201, United States
Sentara Cardiovascular Research Institute
RECRUITING

Norfolk, Virginia, 23507, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Spectrum Health and Hospitals and Corewell
RECRUITING

Grand Rapids, Michigan, 49503, United States
St. Francis Hospital and Heart Center
RECRUITING

Roslyn, New York, 11576, United States
Stanford University Medical Center
WITHDRAWN

Stanford, California, 94305, United States
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States
Tampa General Hospital
RECRUITING

Tampa, Florida, 33606, United States
The Ohio State University Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
The University of Chicago
WITHDRAWN

Chicago, Illinois, 60637, United States
The University of Texas Health Houston
RECRUITING

Houston, Texas, 77030, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UT Dell Medical School- Ascension
RECRUITING

Austin, Texas, 78712, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California
RECRUITING

San Francisco, California, 94143, United States
University of California San Diego
WITHDRAWN

San Diego, California, 92110, United States
University of Colorado Denver
RECRUITING

Aurora, Colorado, 80045, United States
University of Florida Health
RECRUITING

Gainesville, Florida, 32608, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Massachusetts Memorial
RECRUITING

Worcester, Massachusetts, 01655, United States
University of Michigan Health
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Missouri Health Care
RECRUITING

Columbia, Missouri, 65212, United States
University of Nebraska Medical Center
WITHDRAWN

Omaha, Nebraska, 68198, United States
University of North Carolina Chapel Hill
WITHDRAWN

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
University of Washington
RECRUITING

Seattle, Washington, 98104, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53792, United States
Washington University School of Medicine
WITHDRAWN

St Louis, Missouri, 63110, United States
Yale University
RECRUITING

New Haven, Connecticut, 06510, United States

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