Could earlier breathing help in ALS? new trial aims to find out

NCT ID NCT07071935

Recruiting now Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether starting non-invasive ventilation (a breathing machine) earlier than usual helps people with ALS. Researchers will use a prediction tool to find those at high risk of breathing problems within 6 months. 48 participants will be randomly assigned to early NIV or standard care. The goal is to gather data for a larger trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Non-invasive ventilation (NIV) device
What this could lead to: If successful, this could show that starting breathing support earlier in ALS improves quality of life and survival, leading to changes in treatment guidelines.
What could go wrong: This is a small pilot study with only 48 people, so results may not apply to everyone. Early NIV may be hard for some to tolerate, and insurance coverage remains a barrier.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis neuromuscular disease respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS (ALS) CHRONIC RESPIRATORY FAILURE NEUROMUSCULAR DISEASE NEUROMUSCULAR DISEASE PATIENTS NON INVASIVE VENTILATION NON-INVASIVE VENTILATION SUPPORT NON-INVASIVE VENTILATORY SUPPORT POSITIVE PRESSURE VENTILATION RESPIRATORY INSUFFICIENCY RESPIRATORY INSUFFICIENCY REQUIRING MECHANICAL VENTILATION

Contacts and locations

Locations

Penn Comprehensive ALS Center at Pennsylvania Hospital
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Penn State Hershey ALS Clinic
RECRUITING

Hershey, Pennsylvania, 17033, United States
Thomas Jefferson University Weinberg ALS Center
RECRUITING

Philadelphi, Pennsylvania, 19107, United States

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