Could a single workout shield damaged muscles? a new trial investigates

NCT ID NCT05599568

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study explores whether a single bout of exercise can protect against muscle damage from a later session—a phenomenon called the repeated bout effect—in people with neuromuscular diseases. Unlike healthy individuals, patients with these conditions may experience muscle damage even with concentric exercise, so the trial tests both concentric and eccentric exercise. Researchers will measure changes in creatine kinase levels after two exercise sessions to see if the protective effect occurs. The findings could help design safer, more effective exercise programs for people with myopathy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Exercise (concentric or eccentric)
What this could lead to
If the repeated bout effect occurs in neuromuscular diseases, it could inform safer exercise programs that reduce muscle damage and improve training benefits for patients.
What could go wrong
This is a small, early study (27 participants) and the effect may not appear in all patients or translate to real-world exercise. Exercise itself carries a risk of muscle damage in this population.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Neuromuscular Research Unit, 3342

    Copenhagen, DK-2100, Denmark

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Other studies related to the condition(s) this trial covers.