New drug combo aims to slow ALS in landmark trial
NCT ID NCT07161999
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial is testing an investigational drug called COYA 302 in 120 adults with ALS. The drug combines two immune-modulating agents to reduce inflammation that may damage nerves. Participants will receive either COYA 302 or a placebo for 24 weeks, with an option to continue on the active drug for another 24 weeks. The study measures changes in muscle function, breathing, and nerve damage markers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- COYA 302 (low-dose interleukin-2 and abatacept biosimilar)
- What this could lead to
- If successful, this could lead to a treatment that slows the progression of ALS, helping people maintain function and independence longer.
- What could go wrong
- This is an early Phase 2 trial with only 120 participants, so results may not apply to everyone. The treatment may not slow the disease or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Austin Neuromuscular Center; National Neuromuscular Research Institute, PLLC
RECRUITINGAustin, Texas, 78759, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Barrow Neurological Institute
RECRUITINGPhoenix, Arizona, 85013, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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California Pacific Medical Center
RECRUITINGSan Francisco, California, 94110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia University Medical Center ALS Center
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hopital Neurologique de Montreal
RECRUITINGMontreal, Quebec, H3A 2B4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Houston Methodist Stanley H. Appel Department of Neurology
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Johns Hopkins
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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London Health Sciences Center
RECRUITINGLondon, Ontario, N6A 3K7, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Neurology Associates, P.C. Somnos Clinical Research
RECRUITINGLincoln, Nebraska, 68510, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northwestern
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nova Southeastern University
RECRUITINGDavie, Florida, 33314, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Temple Neurology
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
Contact Email: •••••@•••••
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Texas Neurology, PA
RECRUITINGDallas, Texas, 75206, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The University of Texas Health Science Center
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Thomas Jefferson University-Weinberg ALS Center
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Of Miami
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of British Columbia
RECRUITINGVancouver, British Columbia, V6T1Z3, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Florida Clinical and Translational Research Center
RECRUITINGGainesville, Florida, 32610, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of South Florida
RECRUITINGTampa, Florida, 33612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Toronto/Sunnybrook Health Sciences Center
RECRUITINGToronto, Ontario, M5S 3H2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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