AMYOTROPHIC LATERAL SCLEROSIS (ALS)

This early-stage study tests a new gene therapy called SNUG01 in 21 adults with ALS. The main goal is to check if it is safe and tolerable, and to see early signs of whether it might slow the disease. Participants receive the treatment via a spinal injection and are closely monit…

This phase 3 trial tests whether adding masitinib to standard ALS treatment (riluzole) can slow the loss of physical function better than placebo. About 412 adults with ALS will take masitinib or a dummy pill for 48 weeks. The main goal is to measure changes in daily abilities an…

This study looks at whether starting breathing support (non-invasive ventilation) earlier than usual can help people with ALS. About 48 adults recently diagnosed with ALS will either start breathing support early or receive standard care. The goal is to see if early use improves …

This study tests a new program called Resilient Together-ALS for people recently diagnosed with ALS and their caregivers. The program uses mind-body techniques to help reduce emotional distress and improve coping. About 20 patient-caregiver pairs will participate to see if the pr…

This study looks at whether giving people with ALS and their caregivers video recordings of their clinic visits helps them feel better and remember important information. About 800 participants (400 patient-caregiver pairs) will be split into two groups: one gets standard written…

This study uses ultrasound to see how non-invasive ventilation (a breathing mask) changes diaphragm movement in 20 people with ALS. Researchers will compare diaphragm motion with and without the ventilator. The goal is to better understand how the ventilator affects breathing mus…