AMYOTROPHIC LATERAL SCLEROSIS (ALS)

This early-stage trial is testing an oral medication called NB-4746 in people with ALS (amyotrophic lateral sclerosis). The main goals are to check the drug's safety, see how the body processes it, and measure if it affects a blood marker of nerve damage. About 80 participants wi…

This study is testing whether adding an oral drug called masitinib to the standard ALS medication (riluzole) can better slow the disease and improve daily function. It will involve 412 adults with ALS who are already taking riluzole. Participants will be randomly assigned to rece…

This study is testing if starting a breathing machine, called non-invasive ventilation (NIV), earlier than the current standard can help people with ALS. Researchers will use a prediction tool to identify patients at higher risk for breathing problems and randomly assign them to …

This is an early-stage trial testing a new gene therapy called SNUG01 for adults with Amyotrophic Lateral Sclerosis (ALS). The main goal is to see if the treatment is safe and tolerable when injected into the spinal fluid. Researchers will also look for early signs that it might …

This study aims to see if providing video recordings of long, complex clinic visits improves quality of life for people with ALS and their caregivers. It will enroll 400 patient-caregiver pairs to compare standard written visit summaries against summaries plus video recordings ov…

This study is testing a new online support program for people recently diagnosed with ALS and their primary caregiver. The program involves six video sessions over six weeks, focusing on building resilience, coping skills, and finding meaning. Researchers want to see if the progr…

This small, early-stage study aims to understand how a breathing support machine (non-invasive ventilation) affects the main breathing muscle (the diaphragm) in people with ALS. Researchers will use an ultrasound machine to take pictures of the diaphragm while patients breathe on…