Can an asthma drug slow ALS? new trial aims to find out

NCT ID NCT07142291

Recruiting now Disease control Sponsor: PhenoNet, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing whether an inhaled drug called cromolyn (PHENOGENE-1A) can help people with mild-to-moderate ALS when added to standard care. About 105 participants will receive either a low dose, high dose, or placebo for 24 weeks. Researchers will measure changes in daily function, breathing, and safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Cromolyn sodium (PHENOGENE-1A) taken by oral inhalation twice daily

What this could lead to

If it works, this could slow functional decline in people with mild-to-moderate ALS, potentially adding months of better quality of life.

What could go wrong

This is an early phase 2 trial with only 105 people. It may fail to show benefit, and cromolyn's effects on ALS are unproven. Side effects from the inhaled drug are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS (ALS)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Barcelona Sea Hospital (Hospital Del Mar De Barcelona)
RECRUITING

Barcelona, 8003, Spain
Centrum Medyczne NeuroProtect (NeuroProtect Medical Center)
RECRUITING

Warsaw, 01-684, Poland
Charité Centrum für Neurologie, Neurochirurgie und Psychiatrie
RECRUITING

Berlin, 13353, Germany
City Clinic Research
RECRUITING

Warsaw, 02-473, Poland
DIAKOVERE Henriettenstift - Klinik für Neurologie und Klinische Neurophysiologie
RECRUITING

Hanover, 30171, Germany
Honor Health Neurology - Bob Bove Neuroscience Institute
RECRUITING

Scottsdale, Arizona, 85251, United States
Hospital General Universitario Dr. Balmis de Alicante
RECRUITING

Alicante, 3010, Spain
Hospital Universitario Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Vall D Hebron
RECRUITING

Barcelona, 8035, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Lange Neurology
RECRUITING

New York, New York, 10065, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Michalski i Partnerzy Lekarze Spółka Partnerska
RECRUITING

Krakow, 31-426, Poland
NEUROHK s.r.o.
RECRUITING

Hradec Králové, 50002, Czechia
SP ZOZ Szpital Uniwersytecki w Krakowie
RECRUITING

Krakow, 51-503, Poland
Sutter Health - California Pacific Medical Center Research Institute
RECRUITING

San Francisco, California, 94115, United States
Thomayer University Hospital - Fakultni Thomayerova nemocnice
RECRUITING

Prague, 14059, Czechia
Universitaetsklinikum Schleswig-Holstein
RECRUITING

Lübeck, 23538, Germany
University Clinical Center of Serbia
RECRUITING

Belgrade, 11000, Serbia
University of California San Diego
RECRUITING

La Jolla, California, 92037, United States