Can an asthma drug slow ALS? new trial aims to find out
NCT ID NCT07142291
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 4 times
Summary
This phase 2 trial is testing whether an inhaled drug called cromolyn (PHENOGENE-1A) can help people with mild-to-moderate ALS when added to standard care. About 105 participants will receive either a low dose, high dose, or placebo for 24 weeks. Researchers will measure changes in daily function, breathing, and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cromolyn sodium (PHENOGENE-1A) taken by oral inhalation twice daily
- What this could lead to
- If it works, this could slow functional decline in people with mild-to-moderate ALS, potentially adding months of better quality of life.
- What could go wrong
- This is an early phase 2 trial with only 105 people. It may fail to show benefit, and cromolyn's effects on ALS are unproven. Side effects from the inhaled drug are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Barcelona Sea Hospital (Hospital Del Mar De Barcelona)
RECRUITINGBarcelona, 8003, Spain
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Centrum Medyczne NeuroProtect (NeuroProtect Medical Center)
RECRUITINGWarsaw, 01-684, Poland
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Charité Centrum für Neurologie, Neurochirurgie und Psychiatrie
RECRUITINGBerlin, 13353, Germany
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City Clinic Research
RECRUITINGWarsaw, 02-473, Poland
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DIAKOVERE Henriettenstift - Klinik für Neurologie und Klinische Neurophysiologie
RECRUITINGHanover, 30171, Germany
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Fakultni Nemocnice Hradec Kralove
RECRUITINGHradec Králové, 50005, Czechia
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Honor Health Neurology - Bob Bove Neuroscience Institute
RECRUITINGScottsdale, Arizona, 85251, United States
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Hospital General Universitario Dr. Balmis de Alicante
RECRUITINGAlicante, 3010, Spain
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Hospital Regional Universitario De Malaga
RECRUITINGMálaga, 29010, Spain
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Hospital Universitario Ramon Y Cajal
RECRUITINGMadrid, 28034, Spain
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Hospital Universitario Vall D Hebron
RECRUITINGBarcelona, 8035, Spain
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Hospital Universitario Virgen Del Rocio
RECRUITINGSeville, 41013, Spain
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Lange Neurology
RECRUITINGNew York, New York, 10065, United States
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Mayo Clinic Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
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Michalski i Partnerzy Lekarze Spółka Partnerska
RECRUITINGKrakow, 31-426, Poland
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NEUROHK s.r.o.
RECRUITINGHradec Králové, 50002, Czechia
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SP ZOZ Szpital Uniwersytecki w Krakowie
RECRUITINGKrakow, 51-503, Poland
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Sutter Health - California Pacific Medical Center Research Institute
RECRUITINGSan Francisco, California, 94115, United States
-
Thomayer University Hospital - Fakultni Thomayerova nemocnice
RECRUITINGPrague, 14059, Czechia
-
Universitaetsklinikum Schleswig-Holstein
RECRUITINGLübeck, 23538, Germany
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University Clinical Center of Serbia
RECRUITINGBelgrade, 11000, Serbia
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University of California San Diego
RECRUITINGLa Jolla, California, 92037, United States
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