Massachusetts General Hospital

This study tests a tool called Savvy that combines short phone exercises, a weekly pill organizer, and text reminders to help stroke survivors take their blood pressure medication regularly. About 150 adults who had a stroke in the past year and struggle with medication will be f…

This study tests a new therapy called InTEGRA that combines 12-step support with motivational counseling to help teens aged 14-21 reduce alcohol and cannabis use. About 294 teens will be randomly assigned to InTEGRA or standard counseling. The goal is to see if InTEGRA leads to m…

This study looks at whether drinking instant coffee every day for 6 weeks can reduce liver fat and improve gut bacteria in people who have finished treatment for stage I-III colorectal cancer. About 80 adults who completed surgery, chemo, or radiation at least 2 months ago will p…

This pilot study is testing whether a non-invasive device that stimulates the vagus nerve (a key nerve in the neck) is safe and practical for patients who have had a brain bleed from a ruptured aneurysm. About 25 adults in the ICU will receive the stimulation, and researchers wil…

This study tests a precise type of radiation called proton beam therapy for children with neuroblastoma, a nerve cell cancer. The goal is to see if it can control the disease while causing fewer side effects than standard radiation. About 30 participants will receive proton radia…

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination helps keep the cancer from growing for at least 6 …

This study tests whether combining two targeted drugs, afatinib and pemigatinib, is safe and can shrink tumors in people with advanced solid tumors that have specific FGTR gene changes. About 70 adults whose cancers have not responded to standard treatments will take part. The ma…

This early-stage study tests whether adding the drug momelotinib to a standard stem cell transplant is safe for people with myelofibrosis, a serious bone marrow cancer. About 28 adults with high-risk disease will receive the drug during and after transplant. The main goal is to f…

This study tests if taking spironolactone for three months after delivery can lower blood pressure and improve heart health in women who had preeclampsia or high blood pressure during pregnancy and were overweight before pregnancy. About 204 women will be randomly assigned to rec…

This study tests whether giving G-CSF (a drug that boosts white blood cells) during standard chemoradiation can help preserve brain structure and thinking abilities in people with a specific type of glioblastoma (MGMT-methylated). About 60 newly diagnosed patients will be randoml…

This study tests a program called ADELANTE for Latinos with HIV whose virus is not well controlled. Participants will either receive five sessions with a community health worker who helps solve problems, or five reminder phone calls. The goal is to see if the program helps more p…

This study tests whether a daily pill called ivosidenib can help prevent acute myeloid leukemia (AML) from returning in people who have a specific IDH1 gene mutation and have already had a stem cell transplant. About 75 adults aged 18 to 75 will receive either the drug or a place…

This study tests a new way to give radiation before surgery for retroperitoneal sarcoma, a rare tumor deep in the abdomen. About 80 adults will receive either proton or photon radiation, with a higher dose to high-risk areas of the tumor. The goal is to find the safest dose and s…

This study tests whether adding the GRACE model—a team-based approach that includes home visits and care coordination—to regular annual wellness visits can improve health and reduce hospital stays for older adults (65+) with complex medical needs. About 6,080 participants will be…

This study tests a new program called QUIT-AD to help people living with HIV or TB quit smoking. The program combines existing methods to support quitting and improve treatment for HIV and TB. Researchers will enroll 86 adults in Cape Town, South Africa, to see if the program is …

This study is for people with advanced melanoma that kept growing after standard immunotherapy. It combines a tumor-freezing procedure (cryoablation) with two immunotherapy drugs (ipilimumab and nivolumab) to see if this approach can control the disease. About 37 adults will take…

This study compares two approved medication plans to treat postmenopausal osteoporosis in women aged 45 and older who have weak bones and a high risk of breaking a bone. Researchers will measure changes in spine bone density over 12 months. The goal is to find which regimen works…

This early-phase study tests two drugs, mezigdomide and talquetamab, together for people with multiple myeloma that has returned or not responded to prior treatments. The main goal is to find the safest dose and schedule. About 25 adults will participate, and researchers will mon…

This study tests whether giving the inhaler Airsupra to adults in the emergency department during an asthma attack can prevent future flare-ups and improve asthma control over 3 months. About 1,860 participants will be randomly assigned to receive Airsupra or usual care. The goal…

This study tests a drug called sacituzumab govitecan, given before surgery, in people with localized triple-negative breast cancer. Some participants may also receive pembrolizumab. The goal is to see if the drug can eliminate all signs of cancer in the breast and lymph nodes by …

This study explores whether time-restricted intermittent fasting can help non-obese adults with non-alcoholic fatty liver disease (NAFLD) reduce liver fat without medication. About 25 participants with a BMI between 23 and 30 will follow a scheduled eating pattern, and researcher…

This study looks at 400 people with stage III colon cancer who have finished standard chemotherapy. A blood test checks for tiny bits of tumor DNA that might mean cancer is still hiding. Some participants get extra treatment (like FOLFIRI or other drugs) while others are watched …

This study looks at two ways to give IV fluids to people with cirrhosis who develop acute kidney injury. One method uses a special algorithm to guide how much fluid to give, while the other follows standard care. The goal is to see which approach is safer and more effective. Abou…

This early-stage study tests a drug called ASTX727 in people with a specific type of brain tumor (IDH mutant glioma) that has come back or is growing. The main goal is to find the highest dose that is safe to give. About 18 adults will take part to help determine the best dose fo…

This study compares two common gout treatment strategies: one that aims to lower urate levels to a target, and another that treats symptoms as they occur. Researchers will track gout flares and quality of life over two years in 650 adults with gout. The goal is to find which appr…

This study tests if the drug eplerenone can improve blood flow to the heart better than a standard blood pressure medication in women who had preeclampsia during pregnancy and now have high blood pressure. About 90 women will take either eplerenone or chlorthalidone daily for 48 …

This study tests whether a medication called dexmedetomidine, given at night, can reduce delirium (sudden confusion) in patients aged 60 and older after heart surgery. About 1,800 participants will receive either the drug or a placebo through an IV or under the tongue. The goal i…

This study tests whether canakinumab, an anti-inflammatory drug, can reduce artery inflammation in 120 adults who have had a heart attack or stent. Some participants have a common genetic change called TET2 clonal hematopoiesis, which may increase inflammation. The goal is to see…

This study tests if limiting calories before surgery can reduce wound complications and improve recovery in adults with soft tissue sarcoma of the leg. Participants will follow a calorie-restricted diet before their surgery and be compared to a control group. The goal is to see i…

This study looks at whether a 12-week home resistance exercise program can help transgender women and gender-diverse people starting estrogen-based hormone therapy maintain muscle mass and strength. Estrogen therapy can reduce muscle and increase fat, raising the risk of a condit…

This study compares two ways to manage high blood pressure after a stroke: home blood pressure monitoring alone versus home monitoring plus group medical visits. High blood pressure is the top cause of a second stroke, so the goal is to find the best way to keep blood pressure un…

This study tests a personalized treatment plan for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or not responded to prior therapy. Participants first receive a combination of two drugs (venetoclax and obinutuzumab). If the …

This study tests different approaches to help people with HIV whose current medication (tenofovir, lamivudine, and dolutegravir, or TLD) is no longer working. It involves 648 adults and teens in Uganda and South Africa. The goal is to find the best strategy to get the virus under…

This study looks at whether switching to a once-daily anti-rejection drug (Envarsus XR) helps preserve memory and thinking in older kidney transplant recipients compared to staying on the standard twice-daily drug (Prograf). About 92 participants who are at least one year post-tr…

This study is testing proton radiation therapy in 100 adults with benign or slow-growing brain tumors. The goal is to see how well it controls tumor growth and how it affects quality of life and side effects. Participants receive targeted proton beams to the tumor area and are fo…

This study tests a mobile game called Change My Story for young people (ages 16-24) living with HIV who also have depression. The game is designed to help them manage stress and stick to their HIV medication. Researchers will compare the game plus standard counseling to counselin…

This study is testing whether adding a new drug (liposomal irinotecan) to the usual chemotherapy and radiation can completely eliminate cancer in people with advanced stomach or esophagus cancer. About 40 adults will receive the drug combination before standard chemoradiation and…

This early-phase study tests whether combining two drugs (atezolizumab and bevacizumab) with targeted radiation is safe for people with liver cancer that cannot be surgically removed. About 20 participants will receive the combination therapy. The main goal is to identify side ef…

This early-phase study tests whether combining two immunotherapy drugs (botensilimab and balstilimab) with targeted radiation can help people whose colorectal cancer has spread to the liver and hasn't responded to standard treatments. About 15 participants will receive the combin…

This study looks at whether using a smartwatch to track activity and body composition, along with exercise reminders, can help people maintain muscle mass and strength while taking popular weight-loss drugs like Ozempic or Mounjaro. Researchers will enroll 100 adults who recently…

This study tests a drug called NPC-1 (made of two natural compounds) in 40 adults aged 55+ who have Alzheimer's disease or early memory problems. The goal is to see if it safely changes blood markers linked to brain health. Participants take the drug for a set period, and researc…

This study tests whether a higher dose of omalizumab can help people with food allergies eat more of their trigger foods without having a reaction. About 30 adults with allergies to peanut, cashew, walnut, egg, or milk will receive the drug for 16 weeks. The main goal is to see h…

This study tests whether the drug elranatamab can lower the chance of multiple myeloma worsening after patients have already received a CAR T-cell therapy called idecabtagene vicleucel (Carvykti). About 32 adults with relapsed or refractory multiple myeloma will take part. The go…

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. About 50 participants aged 50 and older will receive text messages and group sessions. The goal is to see…

This study looks at whether combining two drugs—tirzepatide and bimagrumab—can help adults with obesity lose mostly fat while keeping muscle and bone strong. About 63 participants will receive either the combo, tirzepatide alone, or bimagrumab alone, plus lifestyle advice, over 5…

This study tests whether adding romosozumab to standard estrogen therapy improves bone density in girls and women aged 14-30 who have stopped menstruating due to intense exercise, stress, or an eating disorder. Participants receive either romosozumab or a placebo for 6 months, pl…

This study looks at people with a high genetic risk for heart disease who have early plaque in their arteries but no symptoms. Researchers want to see if taking a high-dose statin and a low-dose anti-inflammatory drug (colchicine) can slow or change the plaque buildup over one ye…

This study tests a device called the Tulavi Allay™ Nerve Cap, placed on cut nerve endings during finger amputation surgery, to prevent painful neuromas and chronic pain. About 20 adults who recently lost a finger due to injury will be enrolled. The goal is to see if the cap reduc…

This study tests whether meal replacements can help low-income adults who are overweight or have prediabetes or type 2 diabetes lose weight and lower blood sugar. Twenty participants will follow an intensive nutrition program for several weeks. Researchers will measure weight los…

This study tests whether giving children (ages 8 to under 18) with newly diagnosed type 1 diabetes repeated doses of the BCG vaccine (normally used for tuberculosis) can improve blood sugar control and reduce insulin needs. The goal is to see if the vaccine can calm the immune at…

This study looks at whether adding nutrition counseling and stress management to standard medication can improve symptoms for people with active Crohn's disease or ulcerative colitis. About 160 adults will be split into four groups, each receiving different combinations of dietit…

This study tests whether a special machine can revive fatty donor livers (30-60% fat) so they can be safely transplanted. About 200 adults on the liver transplant list will receive a treated liver. If successful, this could expand the donor pool and help more people get transplan…

This study tests a 12-week phone coaching program that uses positive psychology and motivational interviewing to help 280 heart failure patients improve their diet, exercise, and medication habits. Participants also receive text messages for up to 24 weeks. The goal is to see if …

This study tests a drug called talazoparib in people with metastatic breast cancer that has a BRCA1 or BRCA2 mutation in the tumor (not inherited). The goal is to see if the drug can slow or stop cancer growth. About 30 participants will take the pill and be monitored for tumor r…

This study tests a combination of four drugs (isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone) in 50 adults with multiple myeloma that has come back or stopped responding to prior treatments. The main goal is to see how many patients' tumors shrink or disappear.…

This study is testing whether giving repeated doses of the BCG vaccine (traditionally used for tuberculosis) can help children aged 8 to 18 with type 1 diabetes. The goal is to see if it improves blood sugar control and reduces insulin needs. 150 participants will be followed to …

This study tests two treatments for people whose cancer has spread to the brain and is growing despite prior therapy. One group receives palbociclib alone; the other gets palbociclib plus pembrolizumab. The goal is to see if these drugs can shrink or stabilize brain tumors. About…

This study tests a new combination of two drugs (elranatamab and isatuximab) given as shots under the skin for people with multiple myeloma that has come back or not responded to at least two prior treatments. The goal is to see if the combination can shrink or control the cancer…

This study tests a drug called epcoritamab in people with a type of blood cancer called large B-cell lymphoma that has come back or not responded to treatment. Participants cannot have a stem cell transplant. The goal is to see if the drug can stop the cancer from growing for at …

This study tests a program called CHAMPION that helps overweight children with asthma manage their weight and breathing. Researchers want to see if doing the program online works as well as meeting in person. About 500 children aged 4 to 17 with asthma and a BMI in the 85th perce…

This study tests whether giving a low-dose anti-inflammatory drug (ketorolac) for just five days after orthopedic surgery can reduce the chance of patients still needing opioids six months later. About 458 adults with serious bone injuries will be randomly assigned to receive eit…

This study tests whether combining three drugs—zanubrutinib, bendamustine, and rituximab—can achieve a very good partial response or better in people with untreated Waldenström macroglobulinemia, a rare blood cancer. About 55 participants will receive the combination therapy. The…

This study tests a combination of three drugs (zanubrutinib, obinutuzumab, and sonrotoclax) in people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The main goal is to see if the treatment can make the cancer undetectable in the blood. Abo…

This early-phase study tests an experimental drug called ziftomenib in adults with acute myeloid leukemia (AML) who have had a stem cell transplant. The goal is to find a safe dose and see if the drug can help prevent the cancer from coming back. About 22 participants will take t…

This study tests if abatacept, a drug used for arthritis, can prevent serious heart problems in cancer patients who develop heart inflammation from immunotherapy. About 390 adults hospitalized with this condition will receive either abatacept or a placebo. The goal is to see if t…

This study looks at whether a medication called SGLT2 inhibitor, already used for diabetes and kidney disease, can improve blood flow to the heart in women with HIV who also have diabetes or kidney problems. About 80 women will be randomly assigned to health education alone or he…

This study is testing a special PET probe called [68Ga]CBP8 to see if it can detect early signs of tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation to measure collag…

This study is working to make testing for cephalosporin antibiotic allergies more accurate. Researchers will use skin tests and controlled drug challenges in 300 adults who have had a possible allergic reaction. The goal is to confirm true allergies and find out which other cepha…

This study tests a special PET scan that uses a tracer called [68Ga]CBP8 to find collagen buildup in the lungs, which is an early sign of interstitial lung disease. Researchers will compare scans from healthy relatives of people with lung fibrosis and from patients with early lun…

This early-stage study aims to find a reliable test for diagnosing oxytocin deficiency in youth with hypopituitarism. Researchers will give a single dose of estrogen/progestin pills to 20 participants (10 with a related hormone deficiency and 10 without) and measure oxytocin leve…

This study is testing a new imaging method called Brillouin microscopy to see if it can better diagnose corneal conditions like keratoconus and ectasia. Researchers will scan the corneas of 168 volunteers, including healthy people, those with keratoconus, and those who had LASIK …

This study looks at whether a special PET scan (flotufolastat F 18) can detect prostate cancer that has come back in men with very low PSA levels (0.20 ng/mL or less) after prostate removal surgery. About 50 men who have had surgery for prostate cancer and now have a small rise i…

This study tests a new capsule camera attached to a string that is gently moved up the lower gut to take pictures. It aims to see if the device can get clear images without needing sedation. The study includes 30 healthy adults and people with Lynch syndrome or inflammatory bowel…

This study tests whether a fluorescent dye called indocyanine green (ICG) can help surgeons see tumor edges more clearly during bone or soft tissue mass removal. About 100 adults having surgery at Massachusetts General Hospital will receive the dye, and doctors will compare how o…

This study is developing a test to find ovarian cancer earlier by looking at DNA from a uterine wash and proteins in the blood. About 250 women scheduled for surgery or at high genetic risk will provide samples before their procedure. Researchers will check how well these markers…

This study aims to see if a special PET/MRI scan can give doctors a complete picture of liver cirrhosis, including scarring, tumors, and blood flow problems. About 45 adults with cirrhosis will get this scan. The goal is to improve diagnosis and monitoring without needing invasiv…

This early-phase study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, cancer, COVID-19, or other clot risks. The goal is to r…

This early-phase study tests a new imaging agent called [68Ga]CBP8 to see if it can safely detect collagen buildup in the lungs of people with pulmonary fibrosis and lung cancer. Researchers will compare scans from healthy volunteers and patients to see if the agent can measure s…

This study looks at whether molecules in saliva can help doctors quickly tell if heart failure is getting worse. Researchers will compare saliva samples from 90 people with stable or worsening heart failure. If successful, this could lead to a simple, painless test to predict hos…

This study tests an AI tool that looks at routine chest X-rays and medical records to find people at high risk for lung cancer. The AI alerts their doctor to discuss screening CT scans. The goal is to see if this alert increases the number of high-risk patients who get screened. …

This study tests whether injecting a near-infrared dye near a lung tumor can help surgeons see the tumor and the first lymph node it drains into during surgery. About 100 adults having lung surgery will receive the dye, and doctors will check if it safely improves tumor removal a…

This study explores whether a simple smell test can help detect early signs of Alzheimer's and other brain diseases. Researchers will have 250 adults with mild memory or behavior concerns, plus healthy older adults, take a 45-minute at-home smell test. The goal is to develop a lo…

This study tests a brain health program for adults aged 50 and older who have mild memory problems but not dementia. The program helps participants make healthy lifestyle changes to reduce dementia risk. Researchers want to see if the program is practical and well-liked by senior…

This study is testing a brief group therapy program called Resilience Training for Teens. The goal is to see if it can prevent serious mental illness in high school students who already have mild symptoms of depression, anxiety, or unusual feelings. About 70 teens aged 14-19 will…

This study tests a program that gives HIV self-test kits and counseling to new mothers and their male partners in South Africa. The goal is to help women start PrEP (HIV prevention pills) and help partners who test positive get HIV treatment. The study includes 120 women and thei…

This early-phase study tests whether tirzepatide, a drug used for diabetes, can lower colorectal cancer risk in adults aged 18-50 with a BMI between 27 and 40. Researchers will measure changes in urine, blood, and gut bacteria markers linked to cancer risk. The goal is to see if …

This study tests a program called PrEP My Way that helps young women (ages 16-24) in Kenya stick with their HIV prevention medicine. Participants can choose between a daily pill, a long-acting injection, or a vaginal ring, plus get support from peers. The goal is to see if offeri…

This study is testing a new web-based tool that gives personalized risk estimates for Crohn's disease to healthy people who have a close family member with inflammatory bowel disease. The goal is to see if learning their personal risk motivates them to make healthy lifestyle chan…

This study is creating a program called TENDAI4PrEP to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program combines problem-solving skills with support for depression and anxiety. Researchers will test it with 132 pregnant women and their health…

This study tests whether a long-acting injectable HIV prevention drug, given every two months, works for adults who inject drugs. 100 participants will receive the shot along with support services. The goal is to see if people stick with this prevention method and if it reduces H…

This study tests whether eating more plants and less meat can lower colorectal cancer risk. Researchers will measure changes in bile acids, gut bacteria, and other markers in 40 adults who have had colon polyps removed. Participants will follow a diet education program for severa…

This study tests whether using special air cleaners (HEPA filters) in elementary school classrooms can lower the amount of viruses in the air and reduce how often students, teachers, and their families get sick. About 200 children and adults from inner-city schools will take part…

This study tests a program called Resilience Training for college students who have mild psychotic experiences, like unusual thoughts or perceptions. The goal is to see if this training can prevent the development of serious mental illness. Researchers will enroll 192 students ag…

This study tests whether writing about a stressful childbirth experience for 15 minutes a day over three days can prevent post-traumatic stress disorder (PTSD) and improve bonding with the baby. Researchers are recruiting 136 women who recently gave birth at Massachusetts General…

This study is testing whether a virtual cognitive behavioral therapy program can help people with cirrhosis who have trouble sleeping. Ten adults with cirrhosis and insomnia will try the program from home. The goal is to see if the program is easy to use and helpful for improving…

This study tests whether using a mild electrical brain stimulation device at home for four weeks can reduce ADHD symptoms and improve focus and self-control. Researchers will enroll 60 adults aged 18-65 with ADHD. Participants will use the device daily and complete questionnaires…

This study tests whether a gentle, non-invasive brain stimulation called tACS can reduce chronic low back pain. Researchers will measure pain levels and brain activity in 80 adults aged 18-60 who have had back pain for over 6 months. The goal is to see if this approach can change…

This study tests a coaching program for pregnant or new-mom doctors to see if it reduces burnout and improves well-being. About 48 residents or fellows will be randomly assigned to receive coaching or not. The program includes one-on-one and group coaching sessions over 4 months,…

This study tests if a gentle electrical stimulation on the ear (called taVNS) can change how the brain and stomach work together in people with functional dyspepsia or gastroparesis. Researchers will use brain scans and stomach activity measurements to see if this non-invasive tr…

This study tests a five-session palliative care program designed for people with metastatic breast cancer and their caregivers. The goal is to help patients talk with their doctors about what matters most to them, especially regarding end-of-life care. The study will include 400 …

This study tests whether cannabidiol (CBD), a non-intoxicating cannabis compound, can reduce brain inflammation in 80 adults with chronic low back pain and mild-to-moderate depression. Participants will receive either CBD or a placebo, and researchers will measure changes in brai…

This study tests whether adding the drug tesamorelin to a home exercise program improves physical function in adults with HIV who are 50-80 years old. Tesamorelin is already approved for belly fat in HIV, and researchers want to see if it also boosts muscle strength and mobility.…

This study tests a smartphone app called SHIFT designed to help stem cell transplant survivors improve their sexual health and quality of life. About 300 adults who had a transplant at least three months ago and have sexual concerns will either use the app or receive standard car…

This pilot study tests whether an 8-week stress reduction program can reduce inflammation in the arteries of adults aged 30-65 who report high stress levels. Researchers will use special PET scans to measure changes in artery inflammation before and after the program. The goal is…

This study tests whether high doses of inhaled nitric oxide gas can help critically ill pneumonia patients on breathing machines recover faster. About 34 adults will receive either the gas or a placebo for 5 days, and researchers will monitor safety and cure rates. The goal is to…

This study tests a virtual, therapist-led sleep program (Survivorship Sleep Program) for cancer survivors with chronic insomnia. About 198 participants will be randomly assigned to the program or standard care. The goal is to see if the program reduces insomnia severity and impro…

This study tests a device called RELiZORB that adds digestive enzymes directly to liquid food given through a feeding tube. It is for people who have trouble digesting food after a severe bout of pancreatitis. The goal is to see if it improves symptoms and quality of life. About …

This study looks at whether adding a special palliative care program (called PEACE) to usual cancer care can help adults with blood cancers like lymphoma, leukemia, or multiple myeloma feel better and have a better experience during treatment. About 90 people will take part, and …

This study tests a behavioral health program called InSTILL for nursing home residents who feel depressed and their main support person. The program aims to help them cope with stressful changes. About 100 pairs of residents and caregivers will be randomly assigned to the program…

This study tests whether whole body hyperthermia (a sauna-like treatment) can reduce symptoms of Long COVID, especially fatigue. Researchers will enroll 21 adults aged 18-65 who had COVID-19 at least 12 weeks ago. Participants will lie on their backs for 2-hour sauna sessions to …

This study tests whether watching guided acupuncture videos can help ease nerve pain caused by chemotherapy in breast cancer survivors. About 20 people who have finished taxane-based chemo will try the video treatment at home. The main goal is to see if the approach is practical …

This study tests a special support program (BMT-CARE) for people caring for a loved one undergoing a bone marrow transplant. The goal is to see if the program improves the caregiver's quality of life and reduces their stress. About 800 caregivers will be randomly assigned to eith…

This study tests tenapanor, a drug already approved for irritable bowel syndrome, as a treatment for constipation in people with cystic fibrosis. About 25 adults with CF will take one tablet twice daily for 4 weeks. Researchers will track bowel movements and use questionnaires to…

This study looks at how well people tolerate laser treatment for port wine birthmarks using an FDA-approved 532 nm laser. Researchers want to compare the standard single high-energy pulse with multiple low-energy pulses to see which causes less discomfort and gives better results…

This study tests whether bezafibrate, a drug used for high cholesterol, can safely improve depression in people with bipolar disorder. Thirty adults with bipolar depression will take bezafibrate along with their usual mood-stabilizing medication for 8 weeks. Researchers will moni…

This study trains psychotherapists to deliver personalized, evidence-based therapies to cancer patients and their caregivers who are feeling high levels of distress. Therapists will choose from approaches like cognitive behavioral therapy, mindfulness, and meaning-centered psycho…

This study tests a new self-directed writing program for people with chronic muscle or bone pain who tend to catastrophize (expect the worst). Ten adults will try the program at home, and researchers will check if it's easy to use, acceptable, and helpful. The goal is to see if t…

This study tests whether a program designed to improve thinking and memory can work for refugees and asylum seekers who have had a traumatic brain injury (TBI). Researchers want to see if the program is practical and helpful. About 50 adults who are refugees or asylum seekers wit…

This study tests a specially adapted mindfulness program for older Black adults (age 50+) who have both chronic pain and mild to moderate depression. Researchers want to see if this approach improves quality of life and reduces pain interference more than a standard health educat…

This study tests a digital app called DREAMLAND designed to improve quality of life and emotional well-being for adults with acute myeloid leukemia (AML) receiving intensive chemotherapy. About 200 participants will use either DREAMLAND or a standard wellness app, and researchers…

This study tests whether using a virtual reality headset and scented necklace can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR and scent therapy or standard care. The goal i…

This study tests a mobile app called PROMOTE designed to help lung cancer survivors improve their physical function, manage breathlessness and sleep problems, and eat healthier. Researchers will enroll 250 people with stage I-III lung cancer who are starting treatment aimed at cu…

This study tests a 16-week remote program that combines positive psychology and motivational interviewing to help 280 adults with type 2 diabetes increase their physical activity. Participants receive coaching sessions and text messages designed to boost motivation and activity l…

This study looks at whether doing heated yoga or regular (non-heated) yoga can reduce symptoms of depression. Researchers will enroll 120 adults aged 18-65 with moderate depression. Participants will practice yoga in either a heated or non-heated room, and their mood will be trac…

This pilot study tests a short counseling program for young adults (ages 25-39) with cancer and their caregiving partners. The goal is to see if the program is practical and helpful for improving coping skills and maintaining a healthy relationship. About 20 couples will take par…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. About 90 parents will be randomly assigned to one of three online programs. Researchers will track changes in how parents accommodate anxiety and…

This study at Massachusetts General Hospital explores whether adding coaching sessions to standard ketamine or esketamine treatment can improve outcomes for people with treatment-resistant depression. Twenty adults currently on maintenance ketamine therapy will receive 12 coachin…

This study looks at two surgical options for people who develop new spine problems near a previous fusion surgery. About 96 adults who had a lumbar fusion at least a year ago will be randomly assigned to either a simpler decompression or a decompression plus additional fusion. Th…

This study tests whether turmeric, a common spice, can reduce pain and stiffness in people with thumb arthritis. Sixty adults aged 40 and older with early-stage thumb arthritis will take turmeric and report their pain levels and daily function. The goal is to see if this natural …

This study is testing a smartphone app called PDAC-PATHWAYS designed to provide information and support to people with pancreatic cancer who are about to start treatment before surgery. About 50 participants will use the app to see if it is helpful and easy to use. The goal is to…

This study tests whether a supplement called pregnenolone can improve depression symptoms in people living with HIV. Participants take either pregnenolone or a placebo pill for a period, while continuing their usual antidepressant medications. Researchers use brain scans and ques…

This study tests whether giving patients pain relief without opioids after major orthopedic surgery is possible and works well. About 100 adults who had bone or joint surgery will either get standard pain medicine (which may include opioids) or an opioid-free plan. The goal is to…

This study tests a new way to weaken traumatic memories in people with PTSD. Participants take propranolol (a blood pressure drug) before briefly recalling their trauma, but some will do it in an unexpected way, like singing the memory. The goal is to see if this 'mismatch' appro…

This study tests whether a smartphone app that teaches better sleep habits, along with a wrist-worn activity tracker, can improve sleep and reduce confusion or memory problems after joint replacement surgery in adults aged 65 and older. About 50 participants will use the app befo…

This study looks at whether heated yoga, sauna sessions, and a mindfulness app can help reduce symptoms of depression. Researchers will enroll 120 adults aged 18-65 with at least moderate depression. Participants will try one of these approaches and report changes in their mood a…

This study tests whether a special exercise routine, done with or without a physical therapist's guidance, can improve muscle strength and walking ability in people with myotonic dystrophy type 2. About 24 adults will be randomly assigned to different schedules of supervised and …

This study tests a new type of whole brain radiation that spares healthy tissue, aiming to improve quality of life and reduce symptoms for people with brain metastases. About 41 adults with solid tumors and brain metastases will receive this radiation plus a standard drug. The ma…

This study tests a support program for people recently diagnosed with a malignant brain tumor. The program includes a guide and one-on-one coaching sessions to help with coping. Researchers want to see if the program is practical and helpful for patients. About 50 adults from Mas…

This study tests two resilience-building programs for cardiac arrest survivors and their caregivers. The goal is to reduce anxiety, depression, and emotional distress while improving quality of life. About 84 pairs (survivor plus caregiver) will participate in a series of session…

This study looks at whether tranexamic acid (TXA), a drug that reduces bleeding, can decrease fluid buildup and shorten the time surgical drains are needed after breast reduction surgery. About 160 adults having elective bilateral breast reduction will be randomly assigned to rec…

This study tests a new program called WISH, which uses positive psychology exercises to help people with irritable bowel syndrome (IBS). Researchers want to see if the program is easy to follow and if it can improve symptoms and well-being. About 50 adults with IBS will either ta…

This study tests a 10-week program called GetActive+ that combines gentle walking with mind-body techniques to help older adults (55+) with long-term muscle or joint pain. Two hundred participants will either join the program or continue their usual care. Researchers will measure…

This study tests whether a single dose of intravenous iron can improve exercise capacity in people with a type of heart failure (HFpEF) who also have low iron levels. About 66 adults with stable heart failure will receive either the iron infusion or a placebo. The main goal is to…

This study tests whether adding a patient's own platelet-rich plasma (PRP) to standard arthroscopic hip labral repair surgery improves pain, function, and quality of life. Researchers will enroll 400 adults with torn hip labrums and compare outcomes between those who receive PRP …

This study tests a digital program called AMP-C for people who have both depression and cannabis use problems. About 80 adults will either use the AMP-C app or just track their symptoms. Researchers will check if the app helps reduce depressive feelings and cannabis use, and if p…

This study tests whether a nasal spray containing oxytocin, often called the 'love hormone,' can reduce binge eating in adults. Researchers will compare oxytocin to a placebo over 8 weeks in 60 people with binge-eating disorder. The goal is to see if it safely lowers binge freque…

This study tests a short, virtual program (6 sessions) designed to prevent long-term emotional distress in people recently diagnosed with young onset dementia (before age 65) and their care-partners. About 388 pairs will participate. The program focuses on building coping skills …

This study looks at whether a type of talk therapy for PTSD (Cognitive Processing Therapy) can also reduce the risk of heart disease. Researchers will measure inflammation and heart rate in 30 adults with PTSD who are at risk for heart problems. Half will receive the therapy righ…

This study is testing a new supportive care program called POISE for people with stage IV non-small cell lung cancer who are on targeted therapy. The program includes four visits with a specially trained palliative care clinician to help patients cope with uncertainty and manage …

This study tests a new program called Sentinel that helps doctors provide extra comfort and support to patients getting a stem cell transplant. The program focuses on improving quality of life and managing symptoms during treatment. About 40 adults will take part to see if the pr…

This study tests two experimental drugs (siltuximab and erenumab-aooe) to see if they can safely reduce chronic pain in people with schwannomatosis, a rare condition that causes painful nerve tumors. About 40 adults with moderate-to-severe pain will receive either the drug or a p…

This study tests a group-based telehealth program called HORIZONS for adults who have chronic graft-versus-host disease after a stem cell transplant. The program is designed to help patients better manage their condition and improve their quality of life. Researchers will compare…

This study tests two different doses of a gel medicine (Purified Cortrophin Gel) given as a single shot to adults having a sudden, painful gout flare. About 150 people will rate their pain over a week to see which dose works better and is safe. The goal is to quickly ease severe …

This study tests whether the drug ruxolitinib can reduce symptoms like fatigue, itching, and night sweats in people with low-risk essential thrombocythemia (ET) or polycythemia vera (PV) who have significant symptom burden. About 60 adults will take ruxolitinib and be monitored f…

This study tests whether a combination of IV ketamine and nasal esketamine can safely reduce suicidal thoughts in people with severe depression. About 100 adults hospitalized for depression will receive the treatments over 24 weeks. The main goals are to see if the treatment is p…

This study is testing a special implant called IlluminOss to see if it can reduce pain and help people move better after pelvic fractures caused by cancer that spread to the bone or by aging. About 100 adults will receive the implant as part of their normal care, and they will fi…

This study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can help with depression and thinking problems after a traumatic brain injury. Ten adults with mild or moderate brain injury who are still depressed will take the combination f…

This study tests whether people with myeloproliferative neoplasms (a type of blood disorder) can stick with a 12-week program that teaches healthier eating and more physical activity. About 30 adults will take part. The main goal is to see if at least 70% of participants can comp…

This study looks at two standard treatments for frozen shoulder (adhesive capsulitis) in adults 18 and older. One group gets physical therapy plus steroid injections, the other gets injections followed by watchful waiting. Researchers want to see if physical therapy improves outc…

This study tests a 12-week remote program that combines positive psychology and motivational interviewing, plus text messages, to help 280 heart attack survivors who are not very active. The goal is to see if this approach increases moderate-to-vigorous physical activity compared…

This study tests a program called QuitVaping, which combines coaching and text message support, to help teens ages 14-18 quit vaping. About 400 teens who vape at least weekly will be randomly assigned to either the QuitVaping program or standard advice and resources. The main goa…

This early-stage study tests a new program designed to help older adults (65+) recover after ostomy surgery. The goal is to improve quality of life and make the recovery process easier. Researchers will interview participants and use questionnaires to see if the program is easy t…

This study is testing a smartphone app called TEC-S designed to help adults who have frequent suicidal thoughts. The goal is to see if the app is safe, easy to use, and can reduce the urge to die by suicide. About 20 adults living near Boston will use the app and report their fee…

This study tests a type of talking therapy (exposure-based CBT) for adults who have both functional dyspepsia (stomach pain or fullness after eating) and avoidant/restrictive food intake disorder (ARFID) with weight loss. The goal is to see if the therapy helps people eat more co…

This study looks at whether giving nutrition during the day instead of at night helps heart surgery patients in the ICU sleep better and keep their natural body rhythms. Researchers will monitor sleep and body temperature in 30 adults. The goal is to see if simple timing changes …

This study aims to develop a new imaging technique called OCT Vibrography that measures how stiff or flexible tissues are inside the body. Researchers will test the device on 90 healthy volunteers, looking at the cornea (front of the eye), skin, and gums. The goal is to see if th…

This study looks at whether a physical activity program can help improve hormone health and reduce diabetes risk in girls ages 8-12 who are at higher risk for conditions like PCOS. About 40 girls will either get a full program with coaching and messages or a lower-intensity versi…

This study aims to understand why Hispanic current and former smokers do not get screened for lung cancer and whether an educational video can help. About 2000 participants will watch the video and answer surveys. The goal is to find better ways to promote early detection.

This study tests if a non-invasive brain stimulation technique called tDCS can improve executive functions like memory, attention, and decision-making in people with various neuropsychiatric conditions. Researchers will enroll 600 adults with diagnoses such as traumatic brain inj…

This study aims to create a test that tells doctors whether a donated liver is healthy enough to transplant. Researchers will take small tissue samples from livers before and after transplant and look for markers that predict how well the liver will work. The goal is to safely us…

This study tests a program called iDECIDE for about 300 middle and high school students who recently broke their school's drug rules. Instead of punishment, students take a course to learn about drug effects and brain development. Researchers will check if the program improves st…

This study looks at tiny particles called extracellular vesicles that are released from fat tissue. Researchers want to understand how these particles carry signals that may affect the heart and liver, especially in people with obesity. By studying samples from 100 patients havin…

This study looks at how the brain processes chronic pain after surgery in 110 adolescents and adults. Researchers will use brain scans and questionnaires to understand why pain persists and how it differs by age. The goal is to find better ways to diagnose and treat this conditio…

This study follows 10,000 breast cancer patients to detect lymphedema—arm swelling—as early as possible. Researchers use arm measurements, symptom surveys, and quality-of-life questionnaires to spot changes during and after treatment. The goal is to improve outcomes by catching s…

This study looks at whether telling people they have a high genetic risk for heart disease motivates them to improve their heart health over one year. Researchers will compare a group that learns their genetic risk to a group that gets standard care. The goal is to see if this kn…

This study looks at how Prolonged Exposure therapy works for people with PTSD. Researchers will measure brain activity, body responses, and symptoms before, during, and after 10 therapy sessions. The goal is to find out what makes the therapy effective and who benefits most. 50 a…

This study is building a large database of health information from up to 5,000 people with ALS and other motor neuron diseases. Participants share details like their symptoms, test results, and disease progression during regular clinic visits. The de-identified data is then share…

This study looks at how a person's genetic makeup changes the way their body responds to oral semaglutide (Rybelsus), a medication used for type 2 diabetes. Researchers will give 125 adults with normal to pre-diabetes blood sugar levels the drug for 14 days and measure blood fact…

This study compares two educational programs designed to help adults with Neurofibromatosis 1 (NF1) and parents of children with NF1 get the recommended health screenings during their regular checkups. The goal is to see which program works better for people who do not visit a sp…

This study aims to understand how the brain processes language by recording brain activity from people with epilepsy who already need brain monitoring. Researchers will compare these recordings to computer models of language. The goal is to learn which brain areas are involved in…

This study looks at whether a single session of mindfulness-based neurofeedback can change brain activity in teens who often get stuck in negative thought patterns. Researchers will compare 50 at-risk teens with 50 healthy teens to see if the training reduces overactivity in a ke…

This study talks to people ages 45-54 who haven't been screened for colorectal cancer, as well as health center staff, to find out what gets in the way. Researchers will interview participants and survey staff to learn how to make screening easier and more acceptable. The goal is…

This study follows 100 active-duty Navy SEALs over 4 years to see if repeated exposure to blasts affects their brain health. Researchers will use brain scans and blood tests to look for early signs of injury. The goal is to create a reliable way to diagnose blast-related brain da…

This study aims to learn more about how the brain controls speech in people with Parkinson's disease, essential tremor, or dystonia. Researchers will record brain activity during deep brain stimulation (DBS) surgery while participants perform speech tasks. The goal is to better u…

This study tests whether a special video and support program, called VIDEO-PEDS, helps parents and doctors have better conversations about treatment goals for children with cancer. About 567 parents of children aged 0-12 with any type of cancer will take part. The goal is to see …

This study looks at bone marrow and bone density in teenagers with cystic fibrosis compared to healthy teens. Researchers will use MRI and other scans to see if teens with CF have more bone marrow fat and how it relates to bone strength. The goal is to better understand bone heal…

This study uses a special PET scan to measure levels of a protein called fibrin in the brains of 30 people, including those with Alzheimer's or related dementias and healthy volunteers. The goal is to see if fibrin builds up differently in certain brain regions. This is an observ…

This study follows 40 people with Angelman syndrome over one year to see how their communication, movement, and daily skills change. Participants visit the study site five times for tests, brain activity recordings (EEG), and sleep tracking at home. The goal is to better understa…

This study looks at whether a gentle, non-invasive brain stimulation technique called rTMS can improve motivation, memory, and brain function in healthy older adults and people with very early Alzheimer's disease. About 80 participants will receive daily stimulation sessions over…

This study is collecting health data from 3000 adults with different types of heart failure to learn how the disease develops and progresses. Researchers will analyze blood samples, images, and medical records to identify distinct patient groups. The goal is to help doctors choos…

This pilot study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from unconsciousness caused by dexmedetomidine, a common sedative. Researchers will also test whether a combination of brain stimulation and EEG can measure brain activit…

This study aims to reduce health inequities in socially vulnerable communities across Massachusetts. It will offer proven programs for weight management, cancer screening, and mental health support to 3,600 adults. The goal is to see if these programs improve health outcomes and …

This study compares two types of lasers used for skin treatments: a new DFG laser and the standard CO2 laser. Researchers want to see if the DFG laser causes less pain and helps the skin heal faster. About 23 healthy adults will receive both laser treatments on small areas of ski…

This study looks at how the drug romosozumab works on bone cells in postmenopausal women with osteoporosis. Researchers want to see if the drug increases bone-forming cells early in treatment but not later. The study involves 16 women who are already prescribed romosozumab and wi…

This study uses a special PET-MR scan to measure the activity of an enzyme called histone deacetylase in the heart. Researchers will compare enzyme levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how this enzyme r…

This study tests a new swallowable capsule that takes detailed images of the esophagus and collects small tissue samples from suspicious areas in people with Barrett's esophagus. The goal is to see if this method can safely gather enough tissue for genetic analysis, which could h…

This study collects blood samples from up to 1,000 adults with PSP, CBS, MSA, or similar brain conditions, plus their family members. Researchers will analyze the DNA to find genes linked to these diseases. No treatment or medication is involved—the goal is simply to learn more a…

This registry enrolls pregnant women aged 18-45 who take psychiatric medications like antidepressants or ADHD drugs. Researchers collect information over the phone and review infant medical records for birth defects. The goal is to gather safety data, not to test a new treatment.

This study tests whether a gentle, non-invasive magnetic pulse to the brain can improve memory in older adults with mild memory problems or early Alzheimer's. About 30 participants will receive daily brain stimulation for two 10-day sessions, with memory tests and brain scans bef…

This study uses a special MRI technique to look at the structure of heart muscle in people at risk for heart failure. Researchers want to see how heart muscle fibers change over time in patients who have had a heart attack or have thickened heart walls. The goal is to better unde…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of people with stable heart disease. About 36 adults who feel stressed and have known heart problems will join. They will have PET/MRI scans before and after the program to measu…

This study tests whether brief, smartphone-based messages can help adults hospitalized for suicidal thoughts use their safety plan when urges are high. Participants answer surveys up to 4 times a day and may receive a just-in-time tip to cope. The goal is to see if these alerts r…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily check-ins, and brain scans to understand these connections. The goal is …

This study uses a non-invasive brain stimulation technique called rTMS to see how stimulating specific brain networks changes mood, thinking, and brain activity. Researchers will compare results from 80 people with major depression and healthy volunteers. The goal is to understan…

This study is testing whether low-intensity focused ultrasound (LIFUP) can help people with severe brain injuries who have not fully recovered consciousness. Researchers will measure changes in behavior and brain activity after the ultrasound sessions. The study involves 36 parti…

This study aims to find biological markers in people who are at risk for inherited prion diseases like Creutzfeldt-Jakob disease. Researchers will collect blood, spinal fluid, and cognitive test results from 150 participants over time. The goal is to predict when symptoms might b…

This study looks at how cannabis use and withdrawal impact depression and suicidal thoughts in teenagers aged 12-18 who use cannabis daily or nearly daily. Researchers will use smartphone surveys several times a day to track mood, cannabis use, and suicidal feelings in real time.…

This study looks at whether an online platform can help adults with neurofibromatosis 1 (NF1) who have low health literacy better understand their symptoms and care. About 50 participants across the U.S. will receive personalized care letters and either educational videos or a ca…

This pilot study works with staff at community health centers to find better ways to increase colorectal cancer screening. Researchers will hold group discussions and analyze health records to see what works. The goal is to make screening easier and more accessible for patients.

This study looks at the spinal fluid and brain activity of people with myotonic dystrophy type 1 to find early signs of brain changes. Researchers will compare these findings with those from healthy volunteers. No treatment is given—the goal is to better understand the disease an…

This study looks at whether using a standard classification system for voice therapy can improve outcomes for people with muscle tension dysphonia (MTD), a condition causing hoarseness or voice strain. About 600 participants will receive standard voice therapy, but clinicians wil…

This study looks at how mild electrical stimulation on the scalp can change brain rhythms linked to working memory. Researchers will test 32 healthy adults using a noninvasive technique called tACS while measuring brain activity with EEG. The goal is to understand how brain waves…

This pilot study is testing whether connecting people who take medication for opioid use disorder to recovery community centers (RCCs) leads to better recovery outcomes. Researchers will compare two groups: one that visits an RCC and one that chooses other recovery activities. Th…

This study looks at how chemotherapy affects thinking and the brain in older adults (age 60+) with breast cancer. Researchers will measure changes in memory and thinking skills, and use brain scans to see if certain proteins are linked to these changes. The goal is to better unde…

This study looks at whether sleep patterns before major orthopedic surgery can help predict delirium (sudden confusion) afterward. Researchers will ask 150 older adults to wear a watch that tracks sleep for two weeks before surgery and give blood samples. The goal is to find slee…

This study tests a 9-session program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been involved with the legal system. The program is designed to help participants understand their mental health better and reduce their chances of f…

This study tests a special care program for adults aged 65 and older who are having planned colorectal surgery. The program focuses on helping patients transition from hospital to home more smoothly. Researchers want to see if it reduces hospital readmissions and deaths within 30…

This study looks at whether a single intravenous dose of allopregnanolone, a natural brain chemical, can help people with PTSD better process traumatic memories. About 96 adults with chronic PTSD will receive either the drug or a placebo and then complete memory tasks. The goal i…

This study tests whether providing emergency department patients with information about local dental clinics and social services helps them actually go to a dentist. About 2,927 adults with dental needs will be split into three groups: one gets general resource handouts, another …

This study is testing a new wireless capsule that you swallow to measure temperature inside your digestive tract. The goal is to see if it can help doctors find diseases like Crohn's disease. Ten healthy adults will take part to check if the capsule works correctly.

This study looks at whether suvorexant (Belsomra), a drug approved for insomnia, can lower brain activity related to cannabis use. Twenty adults who use cannabis daily or near-daily will take the medication for 14 days and have two brain scans. The goal is to see if the drug chan…

This study looks at 1,200 people with T-cell or NK-cell lymphoma to see how their genes affect their response to treatment. Researchers will use machine learning to find patterns that predict survival and whether the cancer comes back. The goal is to move toward personalized trea…

This study is testing whether wearable devices like Fitbits and Apple Watches can help doctors catch complications early after heart or lung surgery. Researchers will use machine learning to analyze data from 1,200 patients to predict recovery quality and detect problems sooner. …

This study tests whether showing a video about advance care planning at home helps people with life-limiting illnesses understand hospice care and document their medical wishes. About 500 adults with a one-year prognosis or less will be randomly assigned to watch the video or rec…

This study is for adults who have had a stroke (blood clot or bleeding in the brain). Researchers want to learn why some people develop memory and thinking problems after a stroke, while others do not. They will use brain scans, blood tests, and memory tests to find clues. The go…

This study looks at whether telling people their genetic risk for heart disease (called a polygenic risk score) helps them lower their cholesterol and improve their heart health over one year. About 500 adults aged 30-75 who are not on cholesterol medication will be randomly assi…

This study looks at how a gentle, noninvasive nerve stimulation on the ear affects the brain and stomach. Researchers will use brain scans and stomach imaging to measure changes in activity. The goal is to understand how this stimulation works in healthy people and those with sto…

This study looks at whether low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers want to see if this group will take part in screening and how well the scans find cancer. The goal is to improve early detection in …

This study looks at how exercise affects brain activity and blood vessel inflammation in people with PTSD who also have or are at risk for heart disease. Researchers will use a special imaging technique (PET/MRI) to measure changes in the arteries and bone marrow. The goal is to …

This study is creating a large database of up to 5,000 children who received radiation therapy for cancer. Researchers want to compare proton beam therapy with standard photon therapy to see which causes fewer long-term side effects. Children under 22 treated at participating cen…

This study looks at how the liver's immune system responds to a chemotherapy drug called melphalan, given directly to the liver through a special procedure. Ten adults with eye melanoma that has spread to the liver will have small tumor samples taken before and after treatment to…

This study aims to understand how the brain changes when people recover arm movement after a stroke. Researchers will enroll 50 people who had a stroke 3-6 months ago and have moderate to severe arm weakness. Participants will either receive intensive arm training or usual care, …

This study uses three types of brain scans (PET, MRI, and EEG) to see how epilepsy affects brain activity and energy use. Researchers will compare scans from 30 healthy adults and people with epilepsy. No treatment is given—the goal is simply to learn more about the condition.

This study examines how long patients fast before surgery and whether that affects their recovery. Researchers will look at problems like nausea, low blood pressure, and kidney injury. The goal is to improve fasting guidelines for the millions of people who have procedures each y…

This study looks at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers will collect samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotio…

This study looks at whether stopping tube feeding for at least 8 hours before a procedure (fasting) or continuing it until right before (not fasting) leads to better recovery in critically ill patients on breathing machines. About 1,072 adults in the ICU will be randomly assigned…

This study looks at bone health in teenagers who were recently diagnosed with Crohn's disease. Researchers will use MRI scans to measure fat in the bone marrow and compare it to healthy teens. The goal is to understand if Crohn's disease affects bone strength early on, which coul…

This study is testing a simple device with motion sensors placed on a child's chest and belly to measure how well their breathing is coordinated. The goal is to see if it can detect breathing problems early, even before they are obvious to doctors. About 20 children aged 28 days …

This early-phase study at Massachusetts General Hospital is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. The study includes 40 people aged 50-80 with Parkinson's disease, multiple system …

This study gathers opinions from patients, families, and doctors about using advanced brain scans and EEG to detect consciousness in people who appear unresponsive after severe brain injury. The goal is not to treat, but to understand what matters ethically when using these techn…

This study follows 500 infants who have a parent or sibling with celiac disease. Researchers collect stool and blood samples over time to track gut bacteria, gut health, and immune responses. The goal is to identify early signs that may predict who will develop celiac disease, wh…

This study is looking for easier ways to track muscle diseases like muscular dystrophy. Instead of taking small pieces of muscle (biopsies), researchers want to see if blood and urine samples, plus painless ultrasound and electrical tests on arms and legs, can give the same infor…

This study tests a short, 6-session program for patients with a recent brain injury and their caregivers. The goal is to prevent long-term emotional distress and improve quality of life. About 388 pairs (patient and caregiver) will take part. The program focuses on building resil…

This study is testing a special PET/MR scan that uses a radioactive tracer to detect scar tissue in the gut of people with Crohn's disease. The goal is to see if the scan can accurately tell the difference between scarred (fibrotic) and inflamed strictures, which could help docto…

This study looks for markers in blood and urine that can show how active and severe myotonic dystrophy is. The goal is to find a less invasive way to measure the disease than taking a piece of muscle (biopsy). Researchers will compare samples from 215 people with and without the …

This study looks at how different parts of the brain talk to each other in healthy adults. Researchers will use safe, non-invasive methods like magnetic stimulation and brain wave recordings to measure these connections. The goal is to better understand normal brain function, not…

This study tests a new, compact imaging capsule that people swallow to take pictures of the esophagus. It includes up to 120 healthy volunteers and people with Barrett's esophagus, a condition that can raise the risk of esophageal cancer. The goal is to see if the capsule is safe…

This study is testing a blood test that looks for tiny pieces of prostate cancer cells floating in the bloodstream, called circulating tumor cells (CTCs). The goal is to see if the number and type of these cells can tell doctors more about the cancer and how it responds to surger…

This study is looking for immune markers that show whether a person is protected from cholera after vaccination or natural infection. About 1,200 healthy people aged 2 to 80 will receive either a cholera vaccine or a typhoid vaccine (as a control) and provide blood samples over t…

This study looks for markers in blood and urine that can show how active and severe Duchenne muscular dystrophy is. The goal is to find a less invasive way to track the disease instead of taking muscle biopsies. Researchers will compare samples from people with Duchenne or Becker…

This study looks at why some people don't get a follow-up colonoscopy after a positive FIT (stool) test for colorectal cancer. Researchers will test simple strategies to help more people complete the colonoscopy, especially in underserved communities. About 45 adults aged 45-75 f…

This study looks at whether blocking out noise from cars, planes, and trains with earplugs can reduce stress and lower the risk of heart disease. Researchers will study 26 adults who are bothered by noise or live in noisy areas and have heart disease risk factors. Participants wi…