Vitamin B3 pill may supercharge brain energy, small study hints

NCT ID NCT07649161

Recruiting now Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking high doses of nicotinamide riboside (a form of vitamin B3) for two weeks can improve brain energy metabolism in 50 healthy adults. Researchers will use special MRI scans and blood tests to measure changes in key brain chemicals. There is no direct health benefit for participants, but the results may help design future studies for brain disorders.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotinamide riboside (Niagen), a form of vitamin B3
What this could lead to: If it works, this could provide a foundation for future studies testing NR as a treatment for brain disorders linked to energy problems.
What could go wrong: This is a small, early study in healthy people, not patients. It only lasts 2 weeks, so any effects may be temporary or not apply to disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY ADULT

Contacts and locations

Locations

Dauten Family Center for Bipolar Treatment Innovation
RECRUITING

Boston, Massachusetts, 02114, United States

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