Can we skip opioids after bone surgery? new study tests a safer pain plan

NCT ID NCT07265557

Recruiting now Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study compares two discharge pain plans for adults after major orthopedic surgery: one with opioids and one without. Researchers want to see if it's possible to run a larger trial that could reduce opioid use. About 100 patients will be randomly assigned to either plan, and the study tracks how well they follow the plan and their pain levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: discharge pain medication prescription (opioid-free vs. usual care with opioids)
What this could lead to: If successful, this could show that an opioid-free pain plan is feasible and effective, potentially reducing opioid dependence after orthopedic surgery.
What could go wrong: This is a small pilot study (100 people) focused on feasibility, not on proving pain control or safety. Results may not apply to all patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for OPIOID are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Musculoskeletal Pain Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID ORTHOPAEDIC RELATED PAIN (MUSCULOSKELETAL PAIN) PAIN PILOT STUDY

Contacts and locations

Locations

Mass
RECRUITING

Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.