Simple Anti-Inflammatory may curb opioid dependence after major trauma
NCT ID NCT06201676
First seen Oct 31, 2025 · Last updated Apr 28, 2026 · Updated 29 times
Summary
This study tests whether giving a low-dose nonsteroidal anti-inflammatory drug (ketorolac) for the first five days after orthopedic trauma surgery can reduce the risk of chronic opioid use. About 458 adults with serious bone injuries will be randomly assigned to receive either standard pain management alone or standard care plus ketorolac. Researchers will track opioid use and pain-related function for six months to see if the short-term anti-inflammatory treatment helps prevent long-term opioid dependence.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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