Massachusetts General Hospital

This study tests a combination of three drugs (zanubrutinib, obinutuzumab, and sonrotoclax) in people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The main goal is to see how many participants achieve undetectable measurable re…

This study tests proton radiation therapy in 100 adults with benign or slow-growing brain tumors. The goal is to see how well it controls tumor growth and affects quality of life and side effects. Participants receive targeted proton beams to shrink or stabilize their tumors whil…

This study tests whether combining tirzepatide (a weight-loss drug) with bimagrumab (an experimental drug) can help adults with obesity lose mostly fat while keeping muscle and bone. About 63 participants will receive either the combo, tirzepatide alone, or bimagrumab alone, plus…

This study tests whether taking spironolactone for three months after giving birth can help lower blood pressure and improve heart health in women who had preeclampsia or high blood pressure during pregnancy. The trial includes 204 women who were overweight before pregnancy and n…

This study is testing a new type of PET/MR scan that uses a special tracer to see scar tissue in the gut of people with Crohn's disease. The goal is to better tell apart scarred (fibrotic) narrowings from inflamed ones before surgery. About 25 adults with Crohn's who are already …

This study is testing a brain health program for people aged 50 and older who have mild memory concerns but not dementia. The program helps participants make healthy lifestyle changes to lower their risk of memory loss. Researchers want to see if the program is practical and well…

This study is testing a web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with the condition. The goal is to see if learning their personal risk motivates them to make healthy lifestyle and diet changes that might p…

This study tests whether giving a low-dose nonsteroidal anti-inflammatory drug (ketorolac) for the first five days after orthopedic trauma surgery can reduce the risk of chronic opioid use. About 458 adults with serious bone injuries will be randomly assigned to receive either st…

This study tests whether bezafibrate, a drug used for high cholesterol, can safely improve depression in people with bipolar disorder. Thirty adults with bipolar depression will take bezafibrate alongside their usual mood-stabilizing medication for 8 weeks. Researchers will monit…

This study tests a non-invasive method called auricular transcutaneous vagal nerve stimulation (taVNS) to see how it changes brain activity and stomach function in people with functional dyspepsia (indigestion) and gastroparesis (delayed stomach emptying). Researchers will use br…

This study looks at whether low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers want to see if this screening method works as well for this group as it has for others. The goal is to find lung cancer early and im…

This study is testing a 9-session program called Changing Lives and Changing Outcomes-9 (CLCO-9) for people with serious mental illness who have been involved with the legal system. The program is designed to help participants understand their mental health better and reduce thei…

This study is testing a blood test that looks for tiny cancer cells floating in the bloodstream of men with early-stage prostate cancer. The goal is to see if the number of these cells before and after prostate removal surgery can tell doctors more about the cancer's stage and ri…

This study looks at whether providing emergency department patients with information about local dental clinics and social services can help them actually go to a dentist. About 2,927 adults with dental problems will be split into three groups: one gets general info, one gets loc…

This study aims to reduce health inequalities in socially vulnerable communities across Massachusetts. It will offer proven programs for weight management, cancer screening, and mental health support to 3600 adults. The goal is to see if these programs improve health outcomes lik…

This study tests whether a smartphone app that helps improve sleep, along with a wrist-worn activity tracker, can protect brain health in older adults after major joint surgery. About 50 people aged 65 and older with mild insomnia will use the app before and after their operation…

This study is collecting health information from 3000 adults with different types of heart failure to learn how the disease develops and changes over time. Researchers will use blood tests, imaging, and medical records to find patterns that can help doctors choose the best treatm…

This study looks at how prolonged exposure therapy works for adults with post-traumatic stress disorder (PTSD). Researchers will track changes in the brain, body responses, and symptoms before, during, and after 10 therapy sessions. The goal is to find out what makes the therapy …

This study involves 1,200 adults undergoing heart or lung surgery. Participants wear a Fitbit, Apple Watch, or Biostrap device to track health data. Researchers use machine learning to analyze this data and detect complications early, potentially improving recovery. The goal is t…

This study looks at tiny particles called extracellular vesicles that are released from fat tissue. Researchers want to understand how these particles carry signals that may affect the heart and liver in people with obesity. About 100 adults having weight-loss surgery will provid…