New drug offers hope for lymphoma patients who Can't get transplants

NCT ID NCT06811272

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tests the drug epcoritamab in 30 people with relapsed or refractory large B-cell lymphoma who are not eligible for a stem cell transplant. Epcoritamab is a bispecific antibody that helps the immune system target and kill cancer cells. The main goal is to see how long patients live without their cancer getting worse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Epcoritamab (a bispecific antibody that helps immune cells attack cancer cells)

What this could lead to

If successful, this could provide a new treatment option for patients with relapsed/refractory large B-cell lymphoma who cannot undergo a stem cell transplant.

What could go wrong

This is a small, early-phase study with only 30 participants, so results may not apply to all patients. Epcoritamab can cause serious side effects like cytokine release syndrome and immune-related reactions.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly follicular lymphoma high grade B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement large B-cell lymphoma primary mediastinal large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma T-cell/histiocyte rich large B cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Newton-Wellesley Hospital

    RECRUITING

    Newton, Massachusetts, 02462, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••