Massachusetts General Hospital

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will work with 50 participants aged 50 and older who have HIV and high stress levels. The pro…

This study tests whether repeat doses of the BCG vaccine (traditionally used for tuberculosis) can improve blood sugar control and reduce insulin needs in children aged 8 to 18 with type 1 diabetes. Researchers will monitor changes in HbA1c, blood sugar swings, and insulin use ov…

This study tests a drug called epcoritamab in 30 people with large B-cell lymphoma that has come back or not responded to treatment. Participants cannot have a stem cell transplant. The goal is to see if the drug can control the cancer and keep it from growing for at least 12 mon…

This study looks for better ways to diagnose allergies to cephalosporin antibiotics, which are commonly used but can cause serious reactions. Researchers will test 300 adults with a history of possible allergic reactions using skin tests and controlled drug challenges. The goal i…

This study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce chronic low back pain. Researchers will enroll 80 adults aged 18-60 who have had low back pain for at least 6 months. Participants will receive either real tACS or a sham (fake) sti…

This study tests a program that gives people recently diagnosed with a malignant brain tumor an information guide and one-on-one coaching sessions. The goal is to see if the program is practical and helpful for patients. About 50 adults from Massachusetts General Hospital will ta…

This study looks at whether adding a special palliative care program (called PEACE) to usual cancer care can improve quality of life for adults with blood cancers like lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly a…

This study trains psychotherapists to provide personalized, evidence-based talk therapies to cancer patients and their caregivers who are feeling high levels of distress. Therapists will choose from approaches like cognitive behavioral therapy or mindfulness to address issues suc…

This study tests a group-based telehealth program called HORIZONS for adults who have chronic graft-versus-host disease after a bone marrow transplant. The program aims to help patients better manage their condition and improve their quality of life. About 350 participants will b…

This study looks at how well a special implant (IlluminOss) works for people with pelvic fractures from cancer that has spread or from aging. The goal is to see if it reduces pain and helps patients move better. About 100 adults will be followed for up to 2 years after surgery, r…

This study looks at 1,200 people with T-cell or NK-cell lymphoma to see how their genes affect their response to treatment. Researchers will use machine learning to find patterns that predict survival and whether the cancer comes back. The goal is to move toward personalized trea…

This study looks at whether blocking out traffic noise with earplugs can lower stress and reduce heart disease risk. Researchers will scan the brains and blood vessels of 26 adults who are bothered by noise or live in loud areas. Participants will either use earplugs or not for 6…

This study tests whether a video and a guide (called VIDEO-PEDS) can improve conversations between doctors and parents of children with cancer. It involves 567 parents and children aged 0-12. The goal is to see if the tool helps parents talk about treatment goals, limits on life …

This study looks at how the brain controls arm movement after a stroke and how rehabilitation therapy changes those brain pathways. Researchers will enroll 50 people who had a stroke 3 to 6 months ago and have moderate to severe arm weakness. Participants will either receive 30 h…

This study uses a gentle, noninvasive technique called transcranial alternating current stimulation (tACS) to temporarily tweak brain rhythms while volunteers perform memory tasks. Researchers will measure brain activity with EEG to understand how certain rhythms help us hold and…

This study is testing whether wearable devices like Fitbit and Apple Watch can help predict complications and recovery in people undergoing surgery or other treatments for benign or malignant conditions. Researchers will use machine learning to analyze data from 2,400 participant…