Massachusetts General Hospital

This study tests a combination of four drugs (carfilzomib, lenalidomide, dexamethasone, and isatuximab) in 50 adults with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. The goal is to see how many patients achieve a complete response after four trea…

This early-phase study tests whether adding an AKT inhibitor (ipatasertib) to standard hormone therapy, with or without a CDK 4/6 inhibitor, is safe and can shrink tumors in women with metastatic hormone receptor-positive breast cancer. About 77 participants will receive the comb…

This study looks at whether eating small, increasing amounts of peanut protein can help people with peanut allergy tolerate a maintenance dose without symptoms. It involves 500 participants aged 6 months to 65 years. The goal is to improve quality of life and reduce allergic reac…

This study tests two targeted drugs, dabrafenib and trametinib, for people with multiple myeloma that has returned or not responded to treatment. The goal is to see if these drugs can shrink the cancer. About 30 adults will take part in this early-phase trial.

This study tests a new, less invasive way to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. Participants swallow a small capsule with a camera that takes pictures of the esophagus. The goal is to see if this method is comfortable and works well in…

This study tests a new way to give proton radiation to children with brain tumors that need radiation to the brain and spine. The goal is to spare the front part of the spine bones to keep more healthy bone marrow and help children grow better. About 20 children aged 3 to 18 will…

This study looks at how the body forms and clears methemoglobin when healthy people breathe high doses of nitric oxide gas. Ten volunteers aged 18–64 will inhale up to 300 parts per million of nitric oxide in short bursts while being closely monitored. The goal is to understand t…

This study aimed to improve how doctors target deep brain stimulation (DBS) for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with medication. Researchers planned to use brain scans to personalize the placement of electrodes. However, the study was w…

This study tests a new camera capsule that people swallow to take pictures of the small intestine. It involves 108 volunteers, some healthy and some with celiac disease. The goal is to see if the procedure is comfortable and if the images are clear enough to help doctors understa…

This early-phase trial enrolls 16 adults with recurrent IDH-mutant gliomas who are scheduled for surgery. Participants take niraparib for one month before their operation so researchers can measure how much drug gets into the tumor and how it affects cancer cells. The goal is to …

This study follows 100 adults with Barrett's esophagus, a condition where the lining of the food pipe changes, to see how it naturally progresses. Participants swallow a small capsule with a camera that takes pictures of their esophagus. The goal is to track changes over time, no…