Massachusetts General Hospital

This study tests whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and reduce inflammation in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for…

This study aimed to see if adding two immune-boosting drugs (zimberelimab and domvanalimab) to standard chemotherapy could help people with operable stomach or esophageal cancer. All participants would have received the treatment before and after surgery, then be followed for up …

This study tests a combination of two drugs—sacituzumab govitecan and talazoparib—in people with metastatic triple-negative breast cancer that has spread. The goal is to see if the pair can shrink tumors and slow the disease. About 75 adults with this aggressive cancer type are t…

This study tests whether the drug larazotide can safely reduce Long COVID symptoms in people aged 7 to 50. Participants take the drug or a placebo four times daily for 21 days. The goal is to see if symptoms like fatigue, brain fog, and breathing problems improve. The trial is no…

This study looks at whether a treatment called oral immunotherapy (OIT) can help people with peanut allergy safely eat small amounts of peanut protein without having an allergic reaction. About 500 people aged 6 months to 65 years will gradually increase their peanut intake under…

This study looks at how to best support parents and caregivers who take care of a child with a tracheostomy at home. About 480 caregivers will be randomly assigned to receive either a standard discharge program or that program plus extra support. Researchers will measure caregive…

This study looks at how transcranial magnetic stimulation (TMS) affects brain connections in people with major depression. About 54 adults who are already scheduled for TMS treatment will have MRI scans before and after therapy. The goal is to understand the brain changes behind …

This study is testing new optical imaging tools that can look at gut tissue samples without destroying them. Researchers want to see if these images can help detect diseases like those affecting the stomach or intestines. About 200 people scheduled for a routine upper endoscopy o…