New test could help rescue discarded livers for transplant

NCT ID NCT03694691

Recruiting now Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to create a 'viability index' to predict whether a donated liver will work well after transplant. Researchers will collect small tissue samples from livers before and after transplant in 60 adults with liver cirrhosis. By measuring certain markers, they hope to develop a tool that can assess liver quality during machine perfusion, potentially increasing the number of usable donor livers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could create a reliable test to determine which donated livers are safe to transplant, potentially increasing the number of usable livers.
What could go wrong: This is an early observational study with only 60 participants, so the index may not be accurate for all patients or livers. It does not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER CIRRHOSES

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

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