Massachusetts General Hospital

This study tests a cancer vaccine (PVX-410) alone or with an immunotherapy drug (durvalumab) in 22 women with stage II or III triple negative breast cancer who have completed standard treatment. The goal is to see if the vaccine is safe and can boost the immune system to help pre…

This trial tests whether an estradiol patch can reduce liver fat and scarring in postmenopausal women with NASH, a progressive form of fatty liver disease. The study enrolls women aged 45-70 with NASH or fatty liver, giving them either a daily estradiol patch or a placebo for a p…

This study tests two targeted drugs, dabrafenib and trametinib, in people with multiple myeloma that has returned or not responded to treatment. The goal is to see if these drugs can shrink the cancer. About 30 adults will take part in this early-phase trial.

This phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…

This study looks at whether a special blood test (TEG-PM) can guide doctors in adjusting blood-thinning medications for people who have had leg artery surgery for peripheral artery disease. About 130 adults will have their blood tested before and up to 9 months after surgery, and…

This phase 2 trial tests the drug pembrolizumab in 101 adults with cancer that has spread to the brain or spinal cord. The goal is to see if the drug can shrink or stabilize these tumors. Participants receive pembrolizumab along with standard imaging and sometimes radiation. The …

This study tests the drug niraparib in 20 people whose cancer has spread to the brain or spinal cord. The goal is to see if the drug can shrink or control these tumors. Participants must have mild or no symptoms from their brain metastases and not need increasing steroids or seiz…

This trial tests a brief, three-session telehealth program called the T1D Parent Check-In for parents of children (ages 8–17) newly diagnosed with type 1 diabetes. The program aims to help parents feel more confident, reduce family conflict, and improve the child's quality of lif…

This study tests whether Truvada, an antiviral drug used for HIV prevention, can reduce levels of Epstein-Barr virus (EBV) in people with multiple sclerosis (MS). EBV is linked to MS, and the hope is that lowering the virus might help control the disease. The trial will enroll 50…

This study tests a combination of two drugs—sacituzumab govitecan and talazoparib—in people with metastatic triple-negative breast cancer that has spread. The goal is to see if the combo can shrink tumors or slow the disease. About 75 adults with advanced cancer are taking part. …

This study tests whether giving a precise dose of radiation directly to the tumor during surgery (intraoperative radiation therapy, or IORT) can help people with pancreatic cancer that has grown into nearby blood vessels. Participants first receive standard chemotherapy and radia…

This study compares a newer pacing method called left bundle branch area pacing (LBBAP) with standard right ventricular pacing in 100 adults who need a pacemaker but have normal heart function. The goal is to see if LBBAP better prevents the decline in heart pumping ability that …

This study is testing whether giving the BCG vaccine (normally used for tuberculosis) twice, four weeks apart, can improve blood sugar control and reduce insulin needs in children aged 8 to 17 who were recently diagnosed with type 1 diabetes. The trial involves 100 participants a…

This study tests whether giving the BCG vaccine (traditionally used for tuberculosis) twice, four weeks apart, can help children aged 8 to 18 with type 1 diabetes. The goal is to see if it improves blood sugar control, reduces insulin use, and lowers the risk of dangerously low b…

This early-phase trial tests a new drug called sotatercept (ACE-011) combined with standard myeloma drugs lenalidomide or pomalidomide and dexamethasone in 33 patients whose multiple myeloma has returned or stopped responding to treatment. The main goal is to find the safest dose…

This early-phase study tests whether adding the drug niraparib to standard radiation therapy after surgery can help prevent triple negative breast cancer from coming back. Niraparib is a PARP inhibitor that blocks cancer cells from repairing their DNA. The study includes 21 adult…

This early-phase study tests a cancer vaccine (PVX-410) alone or with the immunotherapy drug pembrolizumab in 20 women with metastatic triple negative breast cancer who have a specific genetic marker (HLA-A2). The goal is to see if the vaccine safely boosts the immune system to f…

This study tested the immunotherapy drug pembrolizumab in 26 people with high grade meningioma that came back or remained after treatment. The goal was to see if the drug could stop the tumor from growing for at least 6 months. Participants received pembrolizumab and had regular …

This study tests a precise type of proton radiation (IMPT) for people with chordoma or chondrosarcoma in the spine, sacrum, or skull base. The goal is to control the tumor while reducing damage to healthy tissue. Some participants may also have surgery. The study includes 64 adul…

This study is testing whether proton beam radiation can effectively treat germ cell tumors in the brain while causing fewer side effects than standard photon radiation. About 45 participants aged 3 to 25 will receive daily proton radiation for 4 to 8 weeks. Researchers will track…

This study tests whether combining two drugs (niraparib and dostarlimab) with radiation therapy is safe and effective for people with metastatic triple-negative breast cancer that has not responded to immunotherapy or is PD-L1 negative. About 32 adults with this aggressive cancer…

This Phase 2 trial tests whether vedolizumab (Entyvio), a drug used for inflammatory bowel disease, can reduce symptoms of collagenous gastritis—a rare condition causing stomach pain, nausea, and bloating. Eleven participants receive the drug via IV and report their symptoms over…

This study tests whether infliximab, a drug used for inflammatory conditions, can treat colitis (colon inflammation) caused by immune checkpoint inhibitors in people with stage III or IV skin cancer. About 42 participants will receive either infliximab or steroids, and researcher…

This study tests whether combining two immunotherapy drugs (nivolumab and ipilimumab) with radiation therapy can control or shrink tumors in people with colorectal or pancreatic cancer that has specific genetic features (MSS or MSI-high). About 84 adults with advanced disease are…

This study tests whether a high-intensity statin and a low-dose anti-inflammatory drug (colchicine) can slow the buildup of artery plaque in people with a high genetic risk for heart disease. Researchers will use CT scans to measure changes in plaque over one year. The trial invo…

This study tests a combination of four drugs (carfilzomib, lenalidomide, dexamethasone, and isatuximab) in 50 adults newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. The goal is to see how many patients achieve a complete response after four trea…

This Phase 2a study tests whether larazotide, a drug that tightens the gut lining, can reduce long COVID symptoms in people aged 7 to 50. Participants take the drug or a placebo four times daily for 21 days. The goal is to see if it safely improves symptoms like fatigue, brain fo…

This phase 2 trial tests whether adding infliximab (a drug used for arthritis) to standard immunotherapy (pembrolizumab or nivolumab+relatlimab) can prevent severe immune-related side effects in people with advanced melanoma. About 36 patients who have not had prior treatment wil…

This phase 3 trial tests whether adding a local injection of the antibiotic tobramycin to standard IV antibiotics can lower infection rates after open fracture surgery. Open fractures have a high risk of infection because the wound may not get enough blood flow for IV antibiotics…

This study aimed to see if tying off extra veins (collaterals) could help dialysis fistulas mature so they can be used for treatment. It planned to enroll patients whose fistulas were not developing properly. However, the trial was withdrawn before any participants were enrolled,…

This early-phase trial is testing a drug called AZD6738 in 52 people with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) whose disease got worse after standard therapy. The drug works by blocking a DNA repair pathway that cancer cells rely on, causing th…

This phase 2 trial tests whether a combination of two drugs, venetoclax (a pill) and azacitidine (an infusion), works better than standard intensive chemotherapy for adults newly diagnosed with acute myeloid leukemia (AML). The study enrolls 172 fit adults and measures how long t…

This study tests whether combining two targeted drugs, alectinib and cobimetinib, can safely treat advanced ALK-positive non-small cell lung cancer. Researchers will first find the best dose with acceptable side effects, then measure how often tumors shrink. The trial enrolls 16 …

This phase 2 trial tests whether combining two immunotherapy drugs (durvalumab and tremelimumab) with radiation can shrink tumors in people with advanced liver or bile duct cancer. The study enrolled 37 adults whose cancer had spread or could not be removed by surgery. The goal i…

This study tests whether combining standard chemotherapy (cisplatin) and radiation with an immunotherapy drug (pembrolizumab) can shrink or control advanced vulvar cancer that cannot be removed by surgery. The trial includes 24 adults with unresectable, recurrent, or metastatic v…

This study tests whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and reduce inflammation in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for…

This phase II trial tested a combination of three drugs—pembrolizumab (Keytruda), dabrafenib (Tafinlar), and trametinib (Mekinist)—in 16 people with advanced melanoma that could not be removed by surgery. The goal was to see if a shorter course of targeted therapy, followed by im…

This early-phase study tested the safety and best dose of adding bevacizumab to standard chemotherapy and radiation for people with soft tissue sarcoma that can be removed by surgery. The goal is to see if this combination can reduce the chance of the cancer returning after surge…

This study tests whether fecal microbiota transplant (FMT) capsules are safe and doable for people with auto-brewery syndrome, a rare condition where gut microbes turn carbs into alcohol. Eight adults will take antibiotics and a colon cleanse, then receive five FMT capsules over …

This study tests a higher dose of a precise type of radiation called proton therapy for people with aggressive meningiomas (brain tumors). The goal is to find a safe dose that can better control the tumor after surgery. The study includes 21 participants with either grade II or g…

This study compares two FDA-approved medications, romosozumab and denosumab, for treating postmenopausal osteoporosis. Researchers will measure changes in hip bone density over 12 months in 50 women at high fracture risk. The goal is to see which drug works better to strengthen b…

This study tests whether repeated doses of the BCG vaccine (originally for tuberculosis) can help adults with long-standing type 1 diabetes lower their blood sugar levels. About 150 participants receive either BCG or a placebo over 5 years, with follow-up for 10 years. The goal i…

This study tests a combination of two drugs, lurbinectedin and doxorubicin, in people with advanced soft-tissue sarcoma or leiomyosarcoma that cannot be cured with standard treatments. The first part finds a safe dose, and the second part compares the combination to lurbinectedin…

This study follows 500 people aged 6 months to 65 years with peanut allergy who are undergoing peanut oral immunotherapy. The goal is to see how many can tolerate a maintenance dose of 300 mg of peanut protein without symptoms within two years. Researchers also track changes in q…

This phase 1 trial tests whether the oral drug Inqovi (decitabine/cedazuridine) can help prevent myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) from returning after a stem cell transplant. About 22 adults who have had a reduced-intensity transplant will …

This phase 2 study tests whether the drug ruxolitinib can help prevent acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) from coming back after a stem cell transplant. About 64 older adults in remission will take ruxolitinib as maintenance therapy. The goal is to see…

This early-phase trial tests a cancer vaccine (PVX-410) combined with two drugs (citarinostat and lenalidomide) in 19 people with smoldering multiple myeloma, a pre-cancer condition. The goal is to see if the combination is safe and can trigger an immune response against myeloma …

This study tests a personalized drug called nL-TUBB4-001, designed specifically for one child with TUBB4A-related leukodystrophy, a rare genetic disease that damages the brain. The drug is an antisense oligonucleotide, which aims to correct the genetic error. The trial will monit…

This phase 2 trial is testing a combination of four drugs—elotuzumab, pomalidomide, bortezomib, and dexamethasone—in 52 patients with multiple myeloma that has relapsed or stopped responding to at least two prior treatments. The goal is to see how many patients achieve a partial …

This study tests whether transplanting healthy gut bacteria from donors can improve confusion in people with advanced liver disease. Thirty participants will receive either fecal transplant capsules or a placebo. The goal is to see if this approach can safely improve thinking and…

This study aimed to compare two ways of managing pain after surgery in people taking buprenorphine for opioid use disorder. One group would continue their usual dose, while the other would receive a lower dose around the time of surgery. The goal was to see which approach better …

This study aimed to see if adding two immune-boosting drugs (zimberelimab and domvanalimab) to standard chemotherapy could help people with operable stomach or esophageal cancer. All participants would have received the treatment before and after surgery, then be followed for up …

This Phase 2 trial is testing whether adding the drug ribociclib (Kisqali) to standard hormone therapy can improve outcomes for people with early-stage ER-positive breast cancer. The study involves 120 participants and focuses on clearing cancer DNA from the blood. The goal is to…

This small pilot study tested the drug eribulin (Halaven) in 13 people with two rare cancers of blood vessels: angiosarcoma and epithelioid hemangioendothelioma (EHE). The goal was to see if the drug could shrink tumors or stop them from growing. Participants had already tried at…

This study tests deep brain stimulation, a device that sends electrical pulses to specific brain areas, for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Only 2 participants are enrolled. The goal is to see if this approach …

This large study compares four FDA-approved medications for bipolar depression to see which one helps people feel better. Over 2,700 adults with bipolar I or II disorder and current depression will be randomly assigned to one of the drugs. The goal is to find which treatment lead…

This study aimed to improve how deep brain stimulation (DBS) is targeted for people with severe obsessive-compulsive disorder (OCD). It planned to use brain scans to personalize the placement of electrodes. However, the trial was withdrawn before enrolling any participants, so no…

This study tests whether a bone marrow transplant, given after a kidney transplant, can help the body accept the new kidney without needing lifelong anti-rejection drugs. About 20 adults aged 18-65 who already have a well-functioning kidney transplant will receive an investigatio…

This early-stage study tests a conditioning regimen to make the recipient's immune system accept a donor kidney without needing lifelong anti-rejection medication. About 20 adults with kidney failure receiving their first transplant from a living donor will participate. The main …

This study tests a precise type of radiation called proton therapy for people with slow-growing brain tumors (low-grade gliomas). The goal is to see if it can control tumor growth as well as standard radiation while causing fewer side effects by sparing healthy brain tissue. Abou…

This phase 2 study tests the drug ruxolitinib (Jakafi) in 50 people who developed bronchiolitis obliterans syndrome (BOS) after a stem cell transplant. BOS is a serious lung condition that causes scarring and breathing problems. The goal is to see if ruxolitinib can improve lung …

This early-stage trial tests whether a stimulant drug (methylphenidate, also known as Ritalin) given through an IV can safely help people with severe brain injuries regain consciousness. Ten adults in a coma or minimally conscious state will receive increasing doses to check for …

This study tests whether adding hydroxychloroquine (a malaria drug) to the targeted cancer pill erlotinib can delay drug resistance in people with advanced EGFR-mutant non-small cell lung cancer. About 76 participants will receive either erlotinib alone or erlotinib plus hydroxyc…

This study compares two common blood thinners—aspirin and enoxaparin (Lovenox)—to see which works better at preventing dangerous blood clots after surgery for bone cancer or cancer that has spread to the bone. About 2,868 adults having pelvic or leg surgery for these conditions w…

This study tests whether giving a short course of targeted radiation (SBRT) along with two immunotherapy drugs (atezolizumab and bevacizumab) before surgery is safe and effective for people with liver cancer that can be removed. About 20 participants will receive this combination…

This study tests whether adding losartan (a blood pressure drug) and nivolumab (an immunotherapy) to standard chemotherapy and radiation can improve surgery outcomes for people with localized pancreatic cancer. About 168 participants with borderline resectable or locally advanced…

This study tests a precise type of radiation called proton therapy for people with a non-cancerous brain tumor called vestibular schwannoma. The goal is to see if this treatment can preserve hearing and control tumor growth while reducing side effects. About 30 adults with useful…

This early-stage trial is testing whether adding an experimental drug called Ipatasertib to standard hormone therapy can help control metastatic hormone receptor positive breast cancer. The study involves 77 women whose cancer has spread and is no longer responding to usual treat…

This study tests whether two special diets—the specific carbohydrate diet or an elemental (liquid) diet—can help people with active Crohn's disease or ulcerative colitis feel better. Forty adults will choose one diet and follow it for 6 weeks, while researchers track symptoms, in…

This study tests a new handheld scanner (LymphaTech) to see if it can accurately measure arm swelling in 100 breast cancer survivors. The goal is to find a faster, easier way to screen for lymphedema, a common side effect of treatment. Researchers will compare the scanner's resul…

This study uses natural language processing, a type of artificial intelligence, to analyze how patients describe their stomach and gut symptoms. Researchers hope to find patterns that help diagnose functional gastrointestinal disorders more accurately. The study will enroll 700 a…

This study tests whether a Samsung smartwatch can detect signs of depression by analyzing heart rate, sleep, and step count. About 220 adults with and without depression will wear the watch for 3 months and complete daily mood surveys. The goal is to see if the watch's 'Mindfulne…

This pilot study tests a new type of breast scan called DBT-TOBI, which combines 3D mammography with light-based imaging. Researchers want to see if it can predict how well breast cancer responds to chemotherapy early in treatment. The study involves 30 women with HER2+ or triple…

This study tests whether a special PET/MRI scan can find endometriosis more accurately than current methods like ultrasound or MRI alone. About 60 women with suspected endometriosis will get the scan before surgery, and results will be compared to surgical findings. If successful…

This study tests whether an artificial intelligence program can use a simple, single-lead handheld ECG device to find people with undiagnosed atrial fibrillation (AF), a common heart rhythm problem. About 200 adults aged 50-90 will use a device at home and complete surveys. The g…

This study tests a simple, at-home smell test to see if it can detect COVID-19 infection and track how smell recovers over time. About 1000 adults, including those with known smell loss and healthy volunteers, will use smell cards to rate odor intensity, identification, and discr…

This study is testing a new, less invasive way to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. Participants swallow a small capsule attached to a thin string, which takes pictures of the esophagus. The goal is to see if this method is comfortabl…

This study tests a special imaging capsule (OFDI) that patients swallow to take detailed pictures of the esophagus. The goal is to see if it can accurately detect Barrett's esophagus, a condition that can lead to cancer. Researchers will compare the capsule's images with standard…

This study looks at whether taking low-dose aspirin can lower the risk of colorectal cancer in people who have already had precancerous polyps removed. Researchers measure changes in certain stem cell markers in the colon and other substances in the blood and urine. The goal is t…

This study tests an 8-week group program called My Healthy Brain for adults aged 50 and older who have memory concerns but not dementia. The program teaches about lifestyle factors like exercise, sleep, and diet that may help prevent dementia. Researchers want to see if the progr…

This study tests whether a single dose of the HPV vaccine (Gardasil 9) can prevent persistent HPV infection in women living with HIV who have already been vaccinated. About 778 women will receive either the HPV vaccine or a meningitis vaccine (placebo) and be monitored for safety…

This study planned to test whether a mobile app-based training program could prevent or lessen mood disorders like depression and anxiety in pregnant women. It was designed for women with low-risk pregnancies who were not currently depressed. However, the study was withdrawn befo…

This study looked at whether taking a daily aspirin can reduce the risk of colorectal cancer in people who have already had a precancerous polyp (adenoma) removed. Researchers measured certain substances in urine and blood that are linked to inflammation and cancer growth. The go…

This study tests whether a single dose of intravenous iron (ferric derisomaltose) can improve exercise capacity in people with heart failure with preserved ejection fraction who also have iron deficiency. About 66 adults will receive either the iron infusion or a placebo, and the…

This study tests whether a specially designed weighted blanket can improve sedation quality and comfort for ICU patients being weaned off a breathing machine. Participants are randomly assigned to receive either the weighted blanket or standard linens during weaning. The blanket …

This study tests a special proton radiation method for children with brain tumors that need radiation to the brain and spine. The new approach spares parts of the backbone to reduce side effects like low blood counts and slowed bone growth. About 20 children aged 3 to 18 will rec…

This study tests a new 20-session cognitive-behavioral therapy for adults aged 18 and older with anorexia nervosa. The goal is to help participants gain weight and reduce eating disorder thoughts and behaviors. Researchers will track changes in weight, anxiety, depression, and ea…

This pilot study asks whether the antibiotic minocycline, the supplement N-acetylcysteine (NAC), or both together can ease depression in people with bipolar disorder. Participants continue their usual mood stabilizer while receiving one of the treatments or a placebo. The goal is…

This study tests a mobile app called Horizons designed to help people with chronic graft-versus-host disease (GVHD) after a stem cell transplant. The app aims to improve quality of life, reduce symptoms, and support coping. About 120 adults with moderate to severe chronic GVHD wi…

This study tests whether watching a video of an avatar receiving acupuncture — and vividly imagining the treatment on oneself — can reduce chronic low back pain. Adults aged 18 to 60 with persistent back pain for over six months will either watch real or sham acupuncture imagery …

This study tested whether a noninvasive brain stimulation technique called tDCS, done at home, could improve thinking problems like brain fog in 31 people with long COVID. Participants used a headset that delivered mild electrical currents to the brain for 4 weeks. The goal was t…

This study tests whether a parent-child therapy program can reduce anxiety in 2- to 3-year-old children who are very fearful or shy. About 90 families will take part in remote sessions. The goal is to see if the therapy helps children feel less anxious and keeps improvements for …

This study tests whether trained older adult peer coaches can help people aged 60+ who have both depressive symptoms and subjective cognitive decline (memory concerns). Participants take part in 8 weekly video chats focused on emotional and practical support. The goal is to see i…

This study looks at whether pramipexole, a drug used for restless leg syndrome, can ease leg symptoms in women with X-linked adrenoleukodystrophy (ALD). About 24 women will take the drug or a placebo for two months. The goal is to see if it improves sleep, walking, and quality of…

This study tests whether a smartphone app that delivers cognitive behavioral therapy (CBT) can help adults with social anxiety disorder. Participants use the app for 12 weeks, learning skills like cognitive restructuring and exposure exercises. The trial compares app users to a w…

This study looked at whether omega-3 fatty acids can reduce inflammation and improve mood in adults with treatment-resistant depression. Fourteen participants who were already on antidepressants but still depressed were randomly given either omega-3 supplements or a placebo for 1…

This study tests whether a non-invasive electrical stimulation of the vagus nerve in the ear (called RAVANS) can improve memory and thinking in 126 older adults. Participants receive either real or sham stimulation during short sessions, and their memory is tested. The goal is to…

This early-phase trial tests whether inhaling a low dose of xenon gas can quickly improve depressive symptoms in 20 people with treatment-resistant major depression or bipolar depression. Participants receive either xenon or a placebo gas added to their usual treatment, and resea…

This study tests a specially adapted stress management program called 3RP-VHL for adults with von Hippel-Lindau disease (VHL), a genetic condition that causes tumors. The program teaches relaxation and resilience skills through 8 video sessions. Researchers want to see if it is f…

This study tests whether monthly alexandrite laser treatments can safely shrink or improve the look of skin tumors in adults with neurofibromatosis type 1 (NF1). Ten participants will receive up to six monthly laser sessions, with some areas treated with cooling and others withou…

This study compares two sedative drugs, remimazolam and propofol, for people having an endoscopy (a tube with a camera used to look inside the body). The goal is to see which drug works better and is safer. About 100 adults will take part, and the study will track how many people…

This trial tests a 6-week program called Ready for Recovery that helps people prepare for aortic aneurysm surgery. The program includes education, healthy habits, stress reduction, and social support. Ten adults having elective surgery will participate to see if the program is fe…

This study looks at whether having therapy sessions in the morning or afternoon changes how well prolonged exposure therapy works for PTSD. About 52 adults with PTSD will receive 10 weekly therapy sessions via telehealth, either early in the day or late afternoon. Researchers wil…

This study tests whether a virtual reality (VR) program can help people undergoing bone marrow transplants cope with stress and improve their quality of life. About 80 adult patients with blood cancer will be randomly assigned to either receive the VR program plus usual care, or …

This study tests a mobile app called THRIVE-M designed to help people with multiple myeloma cope with symptoms, emotions, and relationships. About 120 patients will either use the app or receive usual care. Researchers will measure whether the app improves quality of life, reduce…

This study tests whether a virtual reality program that teaches mindfulness, self-compassion, and understanding others can help people with mood, anxiety, or psychotic disorders feel more at ease in social situations. Researchers are enrolling 174 college students and healthcare …

This study aims to find the best way to deliver cognitive behavioral therapy for insomnia (CBT-I) to cancer survivors who have chronic sleep problems. Researchers are comparing individual vs. group sessions and whether adding booster sessions helps. The goal is to create an effec…

This early study tests whether gentle ultrasound waves aimed at the amygdala (a brain region linked to emotion) can help people with bipolar disorder. Twenty adults with bipolar will receive the ultrasound and have brain scans to see if it calms overactive emotion circuits. The g…

This study compares two types of radiation therapy for low- or intermediate-risk prostate cancer: proton therapy (PBT) and intensity-modulated radiation therapy (IMRT). Both are thought to be equally effective at treating the cancer, but it's unclear which causes fewer side effec…

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. It includes remote monitoring and home visits to reduce the need for hospital stays or emergency room visits. The goal is to see if this approach improves quality…

This early-stage trial tests whether monthly injections of Kybella (a drug that dissolves fat) can safely shrink skin tumors in people with Neurofibromatosis Type 1. Up to 15 adults will receive up to 6 monthly treatments, and researchers will compare treated and untreated tumors…

This study tests a 6-session virtual program called Future Self-BD for adults with bipolar disorder who want to quit smoking. Participants are guided to vividly imagine positive future events that could result from quitting, combined with brief smoking cessation counseling. The t…

This study is testing a new mind-body program called HIPS for adults with chronic hip pain. The goal is to see if the program is practical and helpful for increasing physical activity. Five participants will try the program and give feedback through interviews and surveys. The re…

This study tests a group program called the Relaxation Response Resiliency Program (3RP-AYA) for adolescents and young adults who finished cancer treatment in the last 5 years. The program uses mind-body techniques like imagery, relaxation, and yoga to reduce stress and build res…

This study tests a self-guided web program called Face-Forward-Web for adults with chronic orofacial pain (lasting over 3 months). The program includes five 30-minute video sessions teaching relaxation, mindfulness, and coping skills. Researchers will enroll up to 30 participants…

This study tests whether a telehealth palliative care program is practical and well-liked by people with moderate to severe chronic graft-versus-host disease (cGVHD), a long-term complication after a stem cell transplant. Ten adults will receive up to three video-based palliative…

This study looks at whether adding a palliative care team to standard leukemia treatment helps people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) feel better and have better end-of-life planning. About 320 patients receiving non-intensive therapy will take…

This study tests whether a few counseling sessions can improve quality of life for adults who have just finished lung cancer treatment with the goal of cure. One group gets five sessions focused on coping skills and social support; the other gets one session with referrals. Resea…

This study tests whether using a special cuff that limits blood flow during exercise can help people recover muscle strength and function after Achilles tendon repair surgery. 75 adults who had surgery for a torn Achilles tendon will be randomly assigned to either this blood flow…

This study tests a new support program for adults with lung cancer or mesothelioma who have finished treatment. The goal is to help them improve their quality of life as they move from active treatment to regular check-ups. About 21 participants will try the program to see if it …

This study looks at whether unlicensed professionals can successfully provide cognitive behavioral therapy (CBT) to patients in a general hospital. It includes 250 adults with conditions like anxiety, depression, OCD, and PTSD. The goal is to see if this approach improves psychol…

This study tests a telehealth program called Horizons for adults who have had a stem cell transplant and developed moderate to severe chronic graft-versus-host disease (GVHD). The program uses video sessions and questionnaires to help patients cope and follow their treatment plan…

This study aimed to see if a tiny dose of buprenorphine/naloxone (a medicine used for opioid addiction) could help control pain after surgery in people who already take strong painkillers. It was designed for adults having orthopedic or general surgery. However, the study was wit…

This study tests whether adding a team of specialists—physical therapy, occupational therapy, palliative care, and social work—to standard clinic visits helps people with a ventricular assist device (VAD) feel better and function better. About 110 participants, including newly im…

This study tests whether a mild electrical current applied to the scalp (tDCS) can boost attention and working memory in adults with ADHD. Researchers will vary the strength and duration of the stimulation to find the best dose. 104 participants will complete attention tasks whil…

This study tests a program called the Pregnant Body Project (PBP) for pregnant individuals who have had an eating disorder or disordered eating in the past. The program involves six weekly group sessions on Zoom to help challenge unhealthy body ideals. Researchers want to see if …

This study tests a mobile app called CARE designed to support caregivers of people receiving a bone marrow transplant. The goal is to see if using the app improves the caregiver's quality of life and reduces stress. About 120 adult caregivers will participate, and their well-bein…

This study tests whether bright light therapy can help with sleep and alertness issues in people with Parkinson's disease. Researchers will measure sleep quality, daytime sleepiness, and other non-motor symptoms in 65 participants. The goal is to see if light exposure can improve…

This study looks at how to best support parents and caregivers of children with tracheostomies after they leave the hospital. About 480 caregivers will be randomly assigned to receive either a standard discharge program or one with extra support. Researchers will measure caregive…

This study tests whether a 30-minute music session can reduce stress, anxiety, and pain in adults recovering from heart surgery. Researchers will measure stress hormones, vital signs, and patient-reported feelings in 120 participants. The goal is to see if music offers a simple, …

This study is creating a registry of 500 adults with functional GI disorders like IBS and chronic constipation. Researchers will collect medical data, diet and lifestyle questionnaires, and biological samples to explore genetic, microbial, and environmental factors. The goal is t…

This study tests a new imaging device called OCT-NIRAF that takes detailed pictures inside heart arteries during a standard heart procedure. Researchers want to see if the images can predict which plaques (fatty buildups) will grow and become dangerous. Forty adults with heart di…

This study tests a video-based mobile app designed to reduce mental health stigma and medical mistrust among Black adults with moderate to severe depression or anxiety. Participants watch personal stories from others with similar experiences. The goal is to see if this approach i…

This study looked at how sounds played during sleep affect brain waves and memory in children with Rolandic epilepsy. Researchers used brain scans (MRI, MEG/EEG) to understand which brain circuits are involved. The goal was to find new treatment ideas for this type of childhood e…

This early-stage trial enrolls 16 adults with recurrent IDH-mutant gliomas who are scheduled for surgery. Participants take niraparib for one month before their operation so researchers can measure how much drug reaches the tumor and how it affects cancer cells. The goal is to ga…

This study looks at whether using a laser followed by a gel containing doxycycline (NanoDOX) can help medicine reach deeper into the skin and improve wound healing. About 12 healthy adults will receive the laser treatment and gel on small skin areas, and then have biopsies to mea…

This study uses brain scans (MRI, EEG, MEG) to see how pain alters communication between the thalamus and cortex. Researchers will compare healthy adults and people with chronic low back pain. The goal is to map the brain changes that happen with both short-term and long-lasting …

This study aims to find out which of two educational programs better helps adults with Neurofibromatosis 1 (NF1) and parents of children with NF1 get the recommended health screenings during their regular checkups. Participants live across the U.S. and do not currently visit a sp…

This study tests a new device that takes detailed images of the lower gut during a standard colonoscopy. About 250 adults aged 45 to 75 will have the probe used during their procedure. The goal is to see if the device works well for real-time imaging.

This study tested whether playing quiet sounds during a nap can improve memory. Thirty healthy adults learned a finger-tapping task, napped with either quiet sounds or no sounds, and then repeated the task. Researchers measured brain waves and memory changes to see if sounds help…

This study looks at tiny pieces of RNA in the blood of people with congestive heart failure. Researchers want to see if these RNA levels change with treatment and if they can predict heart health or future heart problems. About 400 adults with heart failure will be followed durin…

This study aimed to develop better MRI scanning methods for imaging fetuses during pregnancy. The goal was to improve image quality and make scans faster and more accurate, even when the baby moves. However, the study was withdrawn before any participants were enrolled, so no res…

This study tests a short, 6-session program for patients with a recent brain injury and their caregivers. The goal is to prevent long-term emotional distress and improve quality of life. About 388 pairs (patient and caregiver) will take part.

This study looks at whether telling people they have a high genetic risk for heart disease helps them make healthier choices. About 200 adults without heart disease will be followed for one year. Researchers will compare heart health scores between those who learn their genetic r…

This study looks at whether estrogen patches can improve mental flexibility and reward processing in young women (ages 14-35) with eating disorders linked to low estrogen. About 120 participants will receive either estrogen patches or placebo for 12 weeks. The goal is to understa…

This study gives ketamine to 120 people with major depression and suicidal thoughts who are not on other psychiatric medications. Researchers use brain scans and a gentle nose swab to see how ketamine changes brain connections and neuron activity. The goal is to understand why ke…

This study is testing a painless, sticker-like skin test in 100 children and teens with suspicious moles. The test looks for certain genetic markers (PRAME and LINC) to see if they match the results from a standard biopsy. The goal is to learn if this noninvasive method can help …

This study is looking for a better way to predict infection risk in people with chronic lymphocytic leukemia (CLL) or multiple myeloma. Researchers will use advanced lab tests on blood samples from 150 participants to find a biomarker that could warn doctors ahead of time. The go…

This study aimed to see if a specially designed website could help men with low-risk prostate cancer understand their treatment options and feel more confident in their choices. The researchers planned to enroll patients and measure their knowledge and decision-making satisfactio…

This study follows 600 children and young adults (ages 2-25) who received radiation therapy for brain tumors or other cancers. Researchers want to understand how treatment affects their quality of life over time, including both positive and negative effects. The goal is to use th…

This study explores whether playing quiet sounds during a nap can help normalize brain activity and improve memory in people with schizophrenia. Researchers will compare memory and sleep patterns in 70 participants (healthy controls and schizophrenia patients) under two condition…

This study is testing a new way to take MRI images of the breast using a very low magnetic field. The goal is to see if this method can produce clearer pictures of breast cancer. About 40 women with benign or malignant breast tumors will be scanned, and the results will be compar…

This study tests whether low intensity focused ultrasound can change negative thought patterns in people with depression. Researchers will target a key brain network involved in mind-wandering and self-judgment. 80 participants will receive both real and sham ultrasound sessions …

This study tests whether giving patients with hand problems like carpal tunnel syndrome or trigger finger a decision aid—a booklet with clear information about their condition and treatment options—helps them feel more satisfied and less conflicted about their choices. About 126 …

This study looks back at medical records of 50 people with Mucolipidosis Type IV (MLIV) to learn how the disease typically progresses. Researchers want to know when children reach or lose developmental milestones, how their movement and vision change, and what lab results look li…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if the probe can detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerati…

This study looks at whether melatonin, a common sleep aid, can improve sleep spindles—special brain waves that help with sleep and attention—in 30 children with autism aged 12-18. Researchers want to understand why sleep and sensory issues happen in autism and test if melatonin c…

This pilot study tests an 8-week program called Move with Meaning, which uses text messages and audio sessions to encourage physical activity in adults aged 45-64. The study involves 30 participants and aims to see if the program is feasible and acceptable. It does not test wheth…

This study looks at 100 women with stage II or III breast cancer to see if proton beam radiation causes less damage to the heart and lungs than standard X-ray radiation. Participants receive either type of radiation as part of a larger trial. Researchers will measure changes in h…

This study aims to collect medical history and tissue or saliva samples from 100 people with a specific type of advanced lung cancer called ALK+ non-small cell lung cancer. Researchers will analyze these samples to better understand the genetic and immune features of the disease.…

This study aimed to collect brain signals related to speech from people with Parkinson's disease during deep brain stimulation (DBS) surgery. The goal was to better understand how the brain controls speech in these patients. However, the study was withdrawn before enrolling any p…

This study looks at how people with chronic cancer pain take their long-acting opioid medications. The goal is to learn from their experiences and develop a better way to manage cancer pain. About 150 adults who are prescribed long-acting opioids for cancer pain will participate.…

This study aimed to find the best level of breathing support (PEEP) for severely obese patients on ventilators. Researchers planned to compare two PEEP levels during breathing tests to see which helped patients breathe easier and come off the ventilator sooner. However, the study…

This study uses a noninvasive brain stimulation technique called TMS, combined with brain scans, to understand working memory problems in people with early psychosis. Twenty participants will receive both active and placebo TMS to see how it affects brain activity and memory perf…

This study is testing whether wearable sensors can reliably monitor movement problems in people with progressive supranuclear palsy (PSP) and related frontotemporal disorders. About 60 participants will wear pendant-like devices for 12 months to track their activity. The goal is …

This study looks at whether certain genes influence how people respond to a meal and a single dose of metformin, a common diabetes medication. Over 1,000 adults without diabetes will take a special drink and then have their blood sugar and other markers measured. The goal is to u…

This study tests whether a special camera capsule, swallowed like a pill, can safely take pictures of the small intestine in children with environmental enteric dysfunction (EED), a gut condition linked to malnutrition. Researchers will also use a thin tube camera through the nos…

This study was designed to observe and compare different treatments for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis, severe skin reactions often caused by medications. Researchers planned to track outcomes like healing time and death rates across hospitals using their…

This study aimed to understand why fractional CO2 laser treatment reduces pain and itch in hypertrophic burn scars. Researchers planned to take small skin samples before and after laser treatment to look at nerve changes. However, the study was withdrawn before any participants w…

This study is creating a large collection of heart images from 1,000 people who have had both a CT scan and a special camera test inside their arteries. The goal is to help researchers better understand atherosclerosis, a condition where arteries become clogged. No new treatments…

This study looks at how transcranial magnetic stimulation (TMS) changes brain connections in people with major depression. Researchers will use MRI scans to measure brain activity before and after TMS treatment. The study involves 54 adults aged 18-80 who are already receiving TM…

This study was designed to test whether giving nitric oxide gas during heart surgery could help protect blood vessels in patients with pre-existing vessel problems. It was an add-on to a larger trial and planned to enroll adults having elective heart surgery with prolonged bypass…

This study was designed to see if a harmless marker (quinine) placed in the mouth could show up in lung secretions, indicating that fluid is leaking past the breathing tube's cuff. It aimed to help detect aspiration in critically ill patients on ventilators. However, the study wa…

This study was designed to measure how breathing nitric oxide gas affects oxidation levels in the blood of heart surgery patients. It was an add-on to a larger trial and planned to enroll adults having elective heart surgery with a bypass machine. However, the study was withdrawn…

This study aimed to measure pressure inside the chest (pleural pressure) in people with morbid obesity using a low-dose CT scan and a thin balloon placed in the esophagus. Researchers planned to compare 6 people with a BMI over 40 to 6 people with a BMI under 30. The study was wi…

This early-phase trial at Massachusetts General Hospital is studying how the body processes high doses of inhaled nitric oxide in 10 healthy adults aged 18–64. Participants breathe the gas for 30 minutes, three times a day, while researchers measure methemoglobin levels—a byprodu…

This study will test whether brief, school-based conversations about alcohol can reduce drinking and drug use among high school students. Over 21,000 students across Massachusetts will be randomly assigned to different intervention approaches, including standard screening and exp…

This study was designed to collect information from patients with hand and upper arm bone or joint problems, both from injuries and other causes. It aimed to learn more about these conditions by gathering data like questionnaire results. However, the study was withdrawn before an…

This study looks at how patients are doing years after finishing treatment for upper-extremity bone or joint problems. Researchers will interview, examine, and sometimes X-ray participants to measure range of motion, pain, and daily function. The goal is to learn more about long-…

This study was designed to test whether adding arm exercises to a standard osteoporosis medication could improve bone density in the wrist. It was planned for postmenopausal women at high fracture risk. However, the study was withdrawn before enrolling any participants, so no res…

This study is testing whether a blood test that looks for tumor DNA can help doctors decide when to safely stop immunotherapy in people with advanced melanoma or non-small cell lung cancer. About 39 patients who have been on immunotherapy for at least a year and show no signs of …

This study looks at how brief, carefully timed bursts of noise played during sleep might help strengthen memory in people with epilepsy who have electrodes implanted in their brain. Researchers will measure brain activity and memory performance to see if the sounds improve how th…

This study compares two types of radiation therapy for left-sided breast cancer: proton beam therapy and conventional photon therapy. The goal is to see which one causes fewer changes to the heart, measured by MRI scans. About 60 adults with non-metastatic breast cancer will part…

This study looks at whether mild whole-body hyperthermia (raising body temperature to about 101.3°F) can help treat major depression by affecting the immune system. Researchers will give some participants a drug that blocks IL-6 (tocilizumab) and others a placebo before the heati…

This study tests whether showing a short video about advance care planning to older adults in the emergency room can increase the number of people who officially document their healthcare wishes. Researchers at Massachusetts General Hospital are enrolling 900 adults aged 65+ (or …

This study compares two treatments for a torn hip labrum in people aged 40 and older: arthroscopic surgery to repair the tear versus physical therapy alone. Researchers want to find out which approach leads to better hip function and less pain. The goal is to help doctors and pat…

This study looks at how problems with the body's internal clock (circadian rhythm) may contribute to REM sleep behavior disorder (RBD), a condition where people physically act out their dreams. Researchers will measure melatonin levels and sleep patterns in 30 adults recently dia…

This study tests whether virtual navigation sessions can help childhood cancer survivors better understand their health insurance and reduce financial stress. About 529 adult survivors will be randomly assigned to live coaching, a recorded version, or usual care. The goal is to s…

This study tests whether an online platform can help older adults in Black communities stick with an 8-week exercise program. About 120 people from churches or senior centers will either follow the standard program or use the online platform plus the program. Researchers will che…

Researchers at Massachusetts General Hospital are testing a new device that goes through the nose to take pictures of the small intestine. The study includes 30 healthy adults and pregnant women in their second trimester. The goal is to see if people can tolerate the device and i…

This study aimed to test a special camera capsule that takes detailed images of the esophagus to diagnose eosinophilic esophagitis and Barrett esophagus. It planned to compare the capsule's images with standard biopsy results. However, the study was withdrawn before any participa…

This study follows 500 adults with Barrett's esophagus for 3 years using a tethered capsule endomicroscopy device—a pill-sized camera that patients swallow. The goal is to track how the condition changes over time without needing sedation or a traditional endoscopy. Researchers h…

This study is testing a new optical imaging device that takes pictures of tissue samples from the stomach and colon during routine endoscopy. The goal is to see if the device can detect signs of disease without needing to remove tissue for a traditional biopsy. Researchers will c…

This study looks at fatty deposits called plaques that can build up in heart arteries and sometimes cause heart attacks. Researchers are using a new imaging method to find a specific type of dangerous plaque in 320 people with heart disease. The goal is to learn more about these …

This study aims to see if a special camera pill can safely take pictures of the esophagus in people with Parkinson's disease. Researchers want to find out if nerve changes in the gut can be seen and compared to healthy people. About 20 adults with Parkinson's will swallow a tiny …

This study looks at tiny RNA molecules in the blood of 200 people hospitalized with acute congestive heart failure. Researchers want to see if these RNA levels change as patients receive decongestive therapy and if they can help predict who will respond well to treatment. The goa…

This study tests a new, less invasive biopsy tool (cryobiopsy) to see if it can collect good tissue samples from the gut. It involves 30 adults already scheduled for a standard endoscopy. The goal is to develop a way to study a gut condition called environmental enteric dysfuncti…

This study tests a new, swallowable camera capsule that takes detailed images of the esophagus. It includes people with eosinophilic esophagitis and healthy volunteers. The goal is to see if the capsule works well and is comfortable to use.

This study tests a thin probe inserted through the nose to measure how leaky the gut is. It involves 15 healthy adults and checks if the device can accurately measure electrical signals in the intestine. The goal is to see if this tool is feasible for future research on gut disea…

This study tests a new, tethered capsule that takes detailed images of the upper small intestine (duodenum) as you swallow it. Researchers want to see if the procedure is comfortable and works well in 108 people, including healthy volunteers and those with celiac disease. The goa…

This study follows 100 adults with Barrett's esophagus, a condition where the lining of the food pipe changes, to see how it naturally progresses. Participants swallow a small camera in a capsule that takes pictures of the esophagus during routine check-ups. The goal is to learn …

This study investigates how electrical stimulation of the thalamus—a brain region key for sleep—can trigger or disrupt sleep brainwaves. Researchers will work with 50 patients who already have electrodes implanted for medical reasons. The goal is to understand how current brain s…

This study looks at how two types of weight-loss surgery affect bone health in teenagers and young adults aged 13-21. Researchers will measure changes in bone density and strength over two years in 240 participants, comparing those who had surgery with those who did not. The goal…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …