Massachusetts General Hospital

This early-phase study tests a cancer vaccine (PVX-410) combined with two other drugs (citarinostat and lenalidomide) in 19 people with smoldering multiple myeloma, a pre-cancer condition. The main goal is to see if the treatment is safe and tolerable, while also checking if it b…

This study tests a cancer vaccine (PVX-410) alone or with an immunotherapy drug (durvalumab) in 22 people with stage II or III triple negative breast cancer who have completed standard treatment. The goal is to see if the vaccine is safe and can boost the immune system to help pr…

This early-phase study tests a cancer vaccine (PVX-410) alone or with an immunotherapy drug (pembrolizumab) in 20 women with metastatic triple negative breast cancer who have a specific genetic marker (HLA-A2). The goal is to see if the vaccine safely boosts the immune system to …

This study tests the drug niraparib in 20 people whose cancer has spread to the brain or spinal cord. The goal is to see if the drug can shrink or control these tumors. Participants must have mild or no symptoms from their brain metastases and not need increasing steroids or seiz…

This study looks at how well two FDA-approved medications help strengthen bones in postmenopausal women at high risk of fractures. Researchers will measure changes in hip bone density over 12 months. The goal is to find the best way to control osteoporosis and prevent breaks.

This study compares a newer pacing method called left bundle area pacing (LBBAP) with the standard right ventricular pacing in 100 adults who need a pacemaker but have normal heart function. The goal is to see if LBBAP better prevents the decline in the heart's pumping ability th…

This early-phase study tests whether an oral drug called Inqovi (decitabine/cedazuridine) can help prevent myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) from returning after a stem cell transplant. About 22 adults who have had a reduced-intensity transp…

This study tested a combination of three drugs (pembrolizumab, trametinib, and dabrafenib) given for a short time to people with advanced melanoma that cannot be removed by surgery. The goal was to see if this approach could shrink or control the cancer for at least 6 months with…

This study compares two common blood thinners—aspirin and low molecular weight heparin—to see which works better at preventing dangerous blood clots after surgery for bone or soft tissue cancer. About 2,868 adults having pelvic or leg surgery for cancer will be enrolled. The goal…

This study looks at how well peanut oral immunotherapy (OIT) works for people with peanut allergy. About 500 participants, aged 6 months to 65 years, will gradually eat small amounts of peanut protein to build tolerance. The main goal is to see if they can safely take 300 mg of p…

This early-phase study tests the drug niraparib given together with radiation therapy after surgery for triple negative breast cancer. It includes 21 patients who still had cancer after chemotherapy. The goal is to find the safest dose and see if it helps prevent the cancer from …

This study tests whether the drug ruxolitinib can help prevent leukemia from coming back after a stem cell transplant in older adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). About 64 participants who are in remission will take ruxolitinib as maintenan…

This study compares infliximab to standard steroid treatment for colitis (inflammation of the colon) caused by immune checkpoint inhibitors in people with stage III or IV skin cancer. The main goal is to see if infliximab can resolve colitis without needing long-term steroids. Ab…

This study tests whether adding the drug ribociclib to standard hormone therapy can better control ER-positive breast cancer after initial treatment. About 120 postmenopausal women with early-stage disease and signs of remaining tumor DNA will receive either the combination or ho…

This study tests a precise type of radiation called proton therapy for people with slow-growing brain tumors (low-grade gliomas). The goal is to see if it can control tumor growth as well as standard radiation while causing fewer side effects by sparing healthy brain tissue. Abou…

This study tests whether digoxin, a heart medication, is safe and tolerable for people with ALS. It also looks at whether digoxin can slow nerve damage. About 40 adults with early-stage ALS will take digoxin for 24 weeks. The goal is to find a new way to control this disease.

This study tests whether combining two immunotherapy drugs (nivolumab and ipilimumab) with radiation therapy can help control colorectal and pancreatic cancers that are either microsatellite stable (MSS) or MSI-high. About 84 adults with these cancers will receive the treatment. …

This study follows 62 adults with hereditary hemorrhagic telangiectasia (HHT) who previously took pomalidomide in a clinical trial. Researchers are checking how well the drug controls nosebleeds and other bleeding over time, as well as its long-term safety. The goal is to see if …

This study tests a combination of two drugs, lurbinectedin and doxorubicin, for people with advanced leiomyosarcoma, a rare soft tissue cancer. The first part finds a safe dose, and the second part compares the combination to lurbinectedin alone to see which works better. About 6…

This study compares a newer, targeted drug combination (venetoclax and azacitidine) to standard chemotherapy for adults newly diagnosed with acute myeloid leukemia (AML). About 172 fit adults will be randomly assigned to one of the two treatments. The goal is to see if the newer …

This early-phase study tests a new drug called sotatercept (ACE-011) combined with standard treatments lenalidomide and dexamethasone in 33 adults with multiple myeloma that has returned or stopped responding to therapy. The main goal is to find the safest dose of sotatercept and…

This study tests whether combining two drugs (niraparib and dostarlimab) with standard radiation therapy can shrink tumors in people with metastatic triple-negative breast cancer that has not responded to immunotherapy or is PD-L1 negative. The trial enrolls 32 adults with advanc…

This study tests an experimental drug called AZD6738 in people with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) whose disease worsened after initial treatment. About 52 adults will take the drug to see if it is safe and can help control the cancer. Th…

This study tests a combination of two drugs—sacituzumab govitecan and talazoparib—in people with metastatic triple-negative breast cancer that has spread. The goal is to see if the combo can shrink tumors and delay cancer growth. About 75 adults with advanced disease are taking p…

This study looks at whether a special team of doctors, nurses, and therapists can help people with a mechanical heart pump (VAD) feel better and have fewer problems. About 110 patients and their caregivers will take part. The goal is to see if this team approach improves quality …

This early-stage study tests a new way to help the body accept a donated kidney without needing lifelong anti-rejection medication. Researchers will give a special conditioning treatment before the transplant to create a mix of the patient's and donor's blood cells, which may tea…

This study tests whether adding losartan (a blood pressure drug) and nivolumab (an immunotherapy) to standard chemotherapy and radiation can help more people with localized pancreatic cancer have successful surgery. About 168 participants with tumors that are borderline or locall…

This study tests whether repeated doses of the BCG vaccine (originally for tuberculosis) can lower blood sugar levels in adults with type 1 diabetes. The trial involves 150 participants and lasts 10 years, with results expected to show if BCG can help control diabetes without rel…

This study tests a deep brain stimulation device in 2 adults with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. The device sends electrical pulses to specific brain areas to help control symptoms. Researchers will track changes in OCD a…

This study tests whether giving a short course of focused radiation (SBRT) along with two drugs (atezolizumab and bevacizumab) before surgery is safe for people with liver cancer that can be removed. About 20 participants will receive this combination, then have surgery. The main…

This study tests whether transplanting gut bacteria from healthy people can help patients with advanced liver disease who suffer from confusion (hepatic encephalopathy). Researchers will first find two top stool donors, then compare their donated bacteria against a placebo in 30 …

This study tested whether wireless monitors worn for 24 hours after a C-section can help detect severe complications like hemorrhage or organ failure. Over 3,000 women in Uganda participated. The goal was to see if this simple technology could reduce maternal deaths and serious i…

This study tests the drug ruxolitinib for people who developed bronchiolitis obliterans syndrome (BOS) after a stem cell transplant. BOS causes lung scarring and breathing problems. The trial enrolls 50 participants and measures if ruxolitinib can improve lung function or prevent…

This study tests if proton beam radiation can safely treat germ cell tumors in the brain and spine while causing fewer side effects than standard photon radiation. About 45 children and young adults (ages 3–25) will receive proton therapy. Researchers will track side effects and …

This study aimed to see if giving the drug amiodarone for a short time after heart surgery could prevent a common complication called atrial fibrillation, which affects up to 1 in 3 patients. The trial planned to include adults with normal heart rhythms before non-bypass heart su…

This early-stage trial is testing the safety and effectiveness of a drug called Ipatasertib combined with hormone therapy for people with metastatic hormone receptor-positive breast cancer. The study includes 77 adult women whose cancer has spread and is no longer responding to s…

This study aimed to see if adding two immune-boosting drugs (domvanalimab and zimberelimab) to standard chemotherapy could help people with operable stomach or esophagus cancer. All participants would have received the drugs before and after surgery. However, the study was withdr…

This study tests a text-message tool designed to help Latino adults with type 2 diabetes take their medication regularly. About 70 participants will use the tool for a few months to see if it is easy to use and helps them manage their diabetes better. The goal is to find a simple…

This study tests whether Truvada, an antiviral drug that fights Epstein-Barr virus (EBV), can reduce EBV levels in saliva and blood of 50 adults with multiple sclerosis (MS). Researchers also want to see if the drug is safe and tolerable for people with MS. The goal is to underst…

This study tests a combination of four drugs—elotuzumab, pomalidomide, bortezomib, and dexamethasone—in people with multiple myeloma that has returned or stopped responding to prior treatments. The goal is to see how many patients achieve at least a partial response and to monito…

This study tests whether giving a precise dose of radiation directly to the tumor during surgery can help people with pancreatic cancer that has grown into nearby blood vessels. Participants had already received chemotherapy and standard radiation before the procedure. The main g…

This study tests two targeted drugs, dabrafenib and trametinib, in 30 people with multiple myeloma that has returned or not responded to treatment. The goal is to see if these drugs can shrink the cancer. Participants must have measurable signs of myeloma. The study is in an earl…

This study tests a precise type of proton radiation called IMPT for people with rare tumors of the spine, sacrum, or skull base (chordoma or chondrosarcoma). About 64 participants receive high-dose radiation, sometimes combined with surgery, to see if it controls the tumor while …

This study tests whether combining two immunotherapy drugs (durvalumab and tremelimumab) with radiation therapy can shrink tumors in people with advanced liver cancer or bile duct cancer. About 37 adults whose cancer cannot be removed by surgery or has spread will receive the tre…

This early-phase study tested the safety and best dose of adding bevacizumab to standard chemotherapy and radiation for people with soft tissue sarcoma that can be removed by surgery. The goal is to see if this combination can reduce the chance of the cancer returning after surge…

This early-phase trial tests whether fecal microbiota transplant (FMT) capsules are safe and feasible for people with auto-brewery syndrome (ABS), a rare condition where gut microbes turn carbs into alcohol. Eight adults with ABS will take antibiotics and a colon cleanse, then re…

This study tested the drug eribulin in 13 people with two rare cancers of the blood vessels: angiosarcoma and epithelioid hemangioendothelioma (EHE). The goal was to see if the drug could shrink tumors or stop them from growing. Participants had advanced disease that had already …

This study tests whether a higher dose of proton radiation can safely control high-grade meningiomas, which are aggressive brain tumors. About 21 adults with specific tumor types after surgery will receive intensity-modulated proton therapy (IMPT). The goal is to find the highest…

This study tests a combination of two drugs, alectinib and cobimetinib, in people with advanced ALK-positive non-small cell lung cancer. The goal is to find the safest dose and see how well the drugs shrink tumors. About 16 adults with stage IV cancer that has an ALK gene change …

This study compares four commonly prescribed medications for bipolar depression in over 2,700 adults. Participants receive one of three FDA-approved drugs or a combination therapy. The goal is to see which treatment leads to remission, meaning fewer depressive symptoms and better…

This study tests a combination of standard chemotherapy (cisplatin), an immunotherapy drug (pembrolizumab), and radiation therapy for people with vulvar cancer that cannot be removed by surgery. The goal is to see if this triple therapy can shrink or control the cancer better tha…

This study tested the immunotherapy drug pembrolizumab in 26 people with high grade meningioma that came back or remained after treatment. The goal was to see if the drug could stop the tumor from growing for at least 6 months. Participants received pembrolizumab and had regular …

This study tested whether adding hydroxychloroquine (a malaria drug) to the standard targeted therapy erlotinib could delay or prevent drug resistance in people with advanced non-small cell lung cancer that has a specific EGFR mutation. About 76 participants received either erlot…

This study tests whether a bone marrow transplant given after a kidney transplant can train the immune system to accept the new kidney without lifelong anti-rejection medication. About 20 adults aged 18-65 who already have a functioning kidney transplant will receive an experimen…

This study tests a combination of four drugs (carfilzomib, lenalidomide, dexamethasone, and isatuximab) in 50 adults with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. The goal is to see how many patients achieve a complete response after four trea…

This study looks at whether two special diets—a liquid formula diet or the specific carbohydrate diet—can help people with active Crohn's disease or ulcerative colitis feel better. About 40 adults will choose one diet and follow it for 6 weeks, then return to normal eating. Resea…

This study tests a custom-made drug (called an antisense oligonucleotide) designed specifically for one child with TUBB4A-related leukodystrophy, a rare genetic brain disease. The goal is to see if the drug is safe and can improve movement, development, and quality of life. Only …

This study tests whether adding infliximab (a drug used for arthritis) to standard immunotherapy can reduce serious side effects while still treating advanced melanoma. About 36 adults with stage 3 or 4 melanoma who haven't had prior treatment will receive either immunotherapy al…

This study tests a precise type of radiation called proton therapy for people with a non-cancerous brain tumor called vestibular schwannoma. The goal is to see if this treatment can preserve hearing and control tumor growth while causing fewer side effects than standard radiation…

This study tests if a pill-sized camera on a string can be used during a routine primary care visit to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. About 650 adults from select primary care practices will swallow the capsule, and researchers wil…

This study tests a handheld scanner (LymphaTech) to see if it can quickly and accurately measure arm swelling in 100 women treated for breast cancer. The goal is to find a faster, easier way to screen for lymphedema, a common side effect. Results will be compared to a standard de…

This study tests a thin probe placed through the nose into the intestine to measure how leaky the gut is. It involves 15 healthy adults and checks if the device can accurately measure electrical signals and take clear images. The goal is to develop a better way to diagnose condit…

This study tests whether a special PET/MRI scan can find endometriosis more accurately than current methods like ultrasound or MRI alone. Researchers will scan 60 women with suspected endometriosis before they have laparoscopic surgery, then compare the scan results to what surge…

This study tests whether artificial intelligence can help doctors diagnose functional gastrointestinal disorders (FGIDs) — conditions like chronic stomach pain or bloating with no clear physical cause. Researchers will record and analyze how 700 patients describe their symptoms d…

This study looks at whether a small, single-lead ECG device used at home can help find people with undiagnosed atrial fibrillation (AF), a common heart rhythm problem. Researchers will use an AI tool to predict who might have AF and then check them with the handheld device. About…

This study tests a special imaging capsule that people swallow to take pictures of the esophagus. The goal is to see if it can accurately detect Barrett's esophagus, a condition that can lead to cancer. About 130 adults already scheduled for an endoscopy will swallow the capsule,…

This study looks at whether taking aspirin can lower the risk of colorectal cancer in people who have already had a precancerous polyp removed. Researchers are measuring changes in certain body chemicals linked to inflammation and cancer growth. The goal is to find a simple, low-…

This study tests whether adding a local injection of the antibiotic tobramycin directly into the wound, alongside standard IV antibiotics, can lower the chance of infection after open fracture surgery. Open fractures have a high risk of infection because blood flow to the injured…

This study looks at whether a single dose of the HPV vaccine can prevent HPV infection in women living with HIV who have already been vaccinated. About 778 women will be randomly assigned to get the vaccine either right away or later. Researchers will track new infections over ti…

This study planned to test a mobile app designed to prevent depression and anxiety in pregnant women. The app would have provided behavioral tools and support. However, the study was withdrawn before any participants were enrolled, so no results are available.

This study compares two ways of providing HIV prevention medication (PrEP) to young people in South Africa. One group gets PrEP through standard clinic visits, while the other group receives home delivery and support. The goal is to see which method helps more people start and co…

This study looks at whether taking low-dose aspirin can lower the risk of colorectal cancer in people who have already had precancerous polyps removed. Researchers will measure changes in certain stem cell markers in the colon and other substances in the blood and urine. The goal…

This study tested if a safe, low-intensity brain stimulation device used at home could improve thinking problems like brain fog and trouble concentrating in people with long COVID. About 31 adults with these symptoms used the device for 4 weeks. The goal was to see if it helps wi…

This study tests a special program called Horizons for adults who have had a stem cell transplant and developed chronic graft-versus-host disease (GVHD). The program includes counseling and support to help patients manage their symptoms, reduce stress, and take their medications …

This study tests a new web-based program called Face-Forward-Web for adults with chronic orofacial pain (pain in the face or mouth lasting over 3 months). About 30 participants will try the program and provide feedback through surveys and interviews. The goal is to see if the pro…

This study compares two online treatments for adults with depression: group yoga sessions and a type of behavioral therapy called Brief Behavioral Activation (BA). Over 500 participants will be randomly assigned to one of the two groups and followed for 24 weeks. The goal is to s…

This study looks at whether bright light exposure can help people with Parkinson's disease sleep better and feel more alert during the day. Researchers will measure sleep quality, daytime sleepiness, and other non-motor symptoms in 65 participants. The goal is to find a simple, d…

This study compares two treatments for a torn hip labrum in people aged 40 and older: arthroscopic surgery versus physical therapy. The goal is to see which approach better reduces pain and improves hip function. About 110 participants will be followed over time to measure their …

This study tests a program that lets cancer patients be monitored from home during their chemotherapy or radiation treatment. The goal is to see if this approach reduces the need for hospital stays or emergency room visits. About 300 adults with certain cancers (like pancreatic, …

This study tests whether monthly alexandrite laser treatments can safely shrink skin tumors (called cutaneous neurofibromas) in adults with Neurofibromatosis Type 1 (NF1). Ten participants will receive up to six laser sessions, with some areas cooled and others not, to see if the…

This study tests whether a virtual reality program can help bone marrow transplant patients feel less distressed and improve their quality of life. About 80 adults with blood cancer who are hospitalized for a transplant will be randomly assigned to either receive the VR program p…

This study tests whether a parent-child cognitive behavioral therapy (CBT) program can reduce anxiety in 2- and 3-year-olds who are very fearful or shy. About 90 children and their parents will take part, with all sessions done remotely. The goal is to see if early help can ease …

This study looks at how to best support parents and caregivers who take care of children with tracheostomies at home. About 480 caregivers will be placed into two groups: one gets the standard discharge program, and the other gets extra support tools. Researchers will check if th…

This study compares two virtual programs for older adults (60+) who have chronic pain and early signs of memory decline. The goal is to see which program better improves physical function, thinking skills, and emotional well-being. Participants will use activity trackers and comp…

This study tests a mobile app (CARE app) designed to help caregivers of people receiving a bone marrow transplant. The goal is to see if the app improves the caregiver's quality of life and reduces stress. About 120 adult caregivers are taking part, and they will be randomly assi…

This study tested whether resilience training in a virtual reality setting is practical and well-liked by college students and healthcare workers who experience mood, anxiety, or psychotic disorders. Participants used VR to practice social interactions and emotion recognition. Th…

This study looks at whether auto-captioning glasses are easy and helpful for adults with NF2-related schwannomatosis who have hearing loss. Eighteen participants will use the glasses for 12 weeks and report their experience through surveys and interviews. The goal is to see if th…

This study compares two types of radiation therapy—proton beam therapy (PBT) and intensity-modulated radiation therapy (IMRT)—in men with low- or intermediate-risk prostate cancer. Both treatments aim to cure the cancer while sparing healthy tissue, but it's unclear which causes …

This early-stage study tests a stimulant drug (methylphenidate) given through an IV to see if it can safely help people with severe brain injuries regain consciousness. The trial involves 10 adults in a coma or minimally conscious state after traumatic or oxygen-deprived brain in…

This study looks at how common restless leg syndrome (RLS) is in women with X-linked adrenoleukodystrophy (ALD) and tests whether the drug pramipexole can reduce RLS symptoms. About 24 women will take part, first to check for RLS, then to try the medication and see if it improves…

This study tests whether vedolizumab, given through an IV, can reduce symptoms like belly pain, nausea, and diarrhea in people with collagenous gastritis, a rare stomach condition. Eleven participants will receive the drug and report their symptoms over 12 weeks. The goal is to s…

This study aimed to compare two approaches to pain management after surgery in people taking buprenorphine for opioid use disorder. One group would continue their usual dose, while the other would temporarily reduce it. The goal was to see which method better controlled pain and …

This study looks at whether adding a palliative care team to standard leukemia treatment helps adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) feel better and have better end-of-life care. About 320 participants receiving non-intensive therapy will be r…

This study tests a smartphone app called THRIVE-M designed to support the emotional well-being of people with multiple myeloma. Researchers want to see if using the app improves quality of life, reduces anxiety and depression, and lessens fatigue compared to standard care. The st…

This study tests whether adding vitamin D3 to standard anti-TNF therapy can improve symptoms and quality of life in people with active inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 100 participants will receive either vitamin D3 or a pl…

This study tests a program called The Body Project, adapted for pregnancy, to help pregnant individuals with a history of eating disorders reduce body dissatisfaction and disordered eating. About 60 participants in their first or second trimester will be assigned to either the pr…

This study tests whether blood flow restriction resistance training (BFR-RT) helps people regain muscle strength and function after Achilles tendon repair surgery. About 75 adults will be randomly assigned to receive BFR-RT plus standard physical therapy, a sham version, or stand…

This study tests a mind-body program designed to help adults with chronic hip pain become more physically active. Five participants will try the program and give feedback on how helpful and practical it is. The goal is to see if this approach is worth testing in a larger study.

This study looks at whether a 30-minute session of music can help adults recover from heart surgery. Researchers will measure stress hormones, anxiety, pain, and vital signs in 120 patients who listen to music compared to those who receive standard care. The goal is to see if mus…

This study tests whether a mobile app called Horizons can improve quality of life and reduce distress for people living with chronic graft-versus-host disease (GVHD), a long-term complication after a stem cell transplant. About 120 adult patients with moderate to severe chronic G…

This study tests whether the drug larazotide can safely reduce Long COVID symptoms like fatigue, brain fog, and shortness of breath. About 150 people aged 7 to 50 will take either the drug or a placebo for 21 days. Researchers will track side effects and symptom changes using sur…

This study tests a new way of giving proton radiation to children with brain tumors that need radiation to the brain and spine. The goal is to protect the bones in the spine and the bone marrow, which may help children grow better and recover their blood cells faster. About 20 ch…

This study tests if a newer sedative, remimazolam, works better than the standard drug propofol for people having an endoscopy (a tube camera exam of the digestive tract). About 100 adults will be randomly assigned to one of the two drugs. The goal is to see if remimazolam makes …

This study tests whether an 8-week online group program can help teens aged 12-17 with Neurofibromatosis (NF1 or NF2) better cope with stress and improve their quality of life. Participants join secure video sessions focused on managing symptoms and building emotional strength. T…

This study aimed to see if a tiny dose of buprenorphine/naloxone could help control pain after surgery in people who already take strong painkillers. It was designed for adults having orthopedic or general surgery. However, the study was withdrawn before any participants were enr…

This study tests a special stress-reduction program for teens and young adults who have finished cancer treatment. The program teaches skills to manage stress and build resilience. Researchers want to see if it is practical and helpful for this group.

This study tests a brief educational and support program for adults who have just finished lung cancer treatment with the goal of curing their cancer. The program is designed to help improve quality of life and reduce fear of the cancer coming back. About 100 participants will be…

This study tests whether a non-invasive brain stimulation technique called LIFUP can reduce negative thinking and mind-wandering in people with depression. Researchers will use brain scans to see if calming a specific brain region (the posterior cingulate cortex) helps people wit…

This study tests whether a non-invasive brain stimulation technique called RAVANS (a type of vagus nerve stimulation) can improve memory and thinking in older adults. Researchers will measure changes in memory tasks and other cognitive tests. The goal is to see if this safe, expe…

This study tests a new program to help adults with lung cancer improve their quality of life after finishing cancer treatment. About 21 people will take part to see if the program is practical and acceptable. The goal is to support patients as they move from active treatment to r…

This early-phase trial tests whether monthly injections of Kybella (a drug already approved for fat reduction) can safely shrink cutaneous neurofibromas—small, benign skin tumors—in people with Neurofibromatosis Type 1. Up to 15 adults will receive up to 6 monthly treatments, wit…

This study tests a 6-session virtual program called Future Self-BD for adults with bipolar disorder who want to quit smoking. Participants learn to vividly imagine positive future events that could happen if they stop smoking. The study aims to see if this approach is acceptable …

This study looks at whether unlicensed professionals can successfully give cognitive behavioral therapy (CBT) to patients in a general hospital. About 250 adults with conditions like anxiety, depression, OCD, or PTSD will take part. The goal is to see if this approach improves ps…

This study tests different ways to deliver a proven sleep therapy (CBT-I) to cancer survivors who have chronic insomnia. About 80 adults who have finished primary cancer treatment will take part. The goal is to find the best approach to reduce insomnia and improve emotional well-…

This study looks at whether a telehealth palliative care program is practical and well-liked by people with moderate to severe chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. Ten adults will receive three video-based support sessions. The g…

This study is developing and testing a program called Resilient Families (R-FAM) for parents whose babies are in the Neonatal Intensive Care Unit (NICU). The goal is to reduce emotional distress like depression, anxiety, and stress, and improve the couple's relationship. About 10…

This study looks at how a noninvasive brain stimulation technique called TMS affects working memory in people with early psychosis. Researchers will use brain scans to see how TMS changes brain activity. The goal is to understand the brain mechanisms behind memory problems, not t…

This study involves 1,000 adults who use scratch-and-sniff smell cards at home to measure their sense of smell. The goal is to see if these tests can reliably detect smell loss caused by COVID-19 and track recovery over time. Participants include people with known smell loss, tho…

This study is testing a new way to take pictures of breast cancer using a very low magnetic field MRI. The goal is to see if this method can produce clear images that match standard mammograms, ultrasounds, and regular MRIs. About 40 women with benign or malignant breast tumors w…

This study was withdrawn before any participants were enrolled. It was designed to see if adding arm exercises to a bone-building medication could improve bone density in postmenopausal women with osteoporosis. No results are available.

This study looks at whether adding an online platform to an 8-week exercise program helps older adults in Black communities become more active. About 120 people from churches or senior centers will take part. The goal is to see if the online tool is easy to use and keeps people e…

This study tests a remote monitoring platform for people with progressive supranuclear palsy (PSP) and related brain diseases. About 60 participants will wear a pendant sensor and complete monthly assessments for 12 months. The goal is to see if this approach can reliably track m…

This study looks at how different levels of a gentle brain stimulation technique called tDCS affect attention and brain activity in adults with ADHD. About 104 participants will complete attention tasks while their brain waves are measured. The goal is to find the best dose for f…

This study looks at whether melatonin, a common sleep aid, can improve sleep spindles—special brain waves linked to sleep quality—in children with autism aged 12 to 18. Researchers aim to understand why sleep and sensory issues occur in autism by measuring brain activity with a p…

This study tests whether virtual navigation sessions can help childhood cancer survivors better understand health insurance terms like deductibles and co-pays. About 529 adult survivors will be randomly assigned to live sessions, recorded sessions, or usual care. The goal is to s…

This study aimed to test a special camera capsule that people swallow to take detailed pictures of the esophagus. The goal was to see if it could diagnose eosinophilic esophagitis and Barrett esophagus as well as standard biopsy. However, the study was withdrawn before any partic…

This study tested whether showing a video decision aid to older adults in the emergency room helps them document their healthcare wishes. Researchers enrolled 900 people aged 65+ (or 50+ with serious illness) to see if the video leads to more advance care planning records in thei…

This study tests a new tool called a cryobiopsy probe to see if it can get good tissue samples from the gut with less discomfort than standard methods. It involves 30 adults already scheduled for an upper endoscopy. The goal is to find a simpler way to study a gut condition calle…

This study was designed to compare different treatments for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis, severe drug reactions that cause skin to blister and peel. Researchers planned to track recovery, hospital stays, and death rates. However, the study was withdrawn…

This study tests an 8-week program called Move with Meaning that uses text messages and audio to encourage physical activity in adults aged 45-64 who are not very active. The goal is to see if the program is easy to use and helpful. About 30 people will take part.

This study aimed to measure lung pressure in people with severe obesity (BMI over 40) compared to those with normal weight. Researchers planned to use a small balloon in the esophagus and chest CT scans to understand how obesity affects breathing. The study was withdrawn before e…

This study gathers heart scans from 1000 people who already had imaging tests. Researchers will use these images to learn more about atherosclerosis, a condition where arteries get clogged. No new treatments or procedures are given. The goal is to create a resource for future stu…

This study is creating a registry of 500 adults with functional GI disorders like irritable bowel syndrome and chronic nausea. Researchers will collect medical information, diet and lifestyle details, and biological samples to better understand what causes these conditions. The g…

This study looks at how tiny electrical pulses to a deep brain area called the thalamus can change sleep brain waves. Researchers will work with 50 patients who already have brain electrodes for medical reasons. The goal is to learn how current brain stimulation therapies affect …

This study looks at how patients recover over the long term after surgery for upper-extremity fractures or other bone and joint conditions. Researchers will measure joint movement and ask about arm function, pain, and mood. The goal is to better understand recovery patterns and c…

This study tests a 6-week program called Ready for Recovery that helps people prepare for aortic aneurysm surgery. Ten adults having elective repair will participate to see if the program is practical and helpful. The goal is to gather information on feasibility and patient satis…

This study follows 100 adults with Barrett's esophagus, a condition where the lining of the food pipe changes, to see how it develops over time. Participants swallow a small camera in a capsule that takes pictures of the esophagus during routine check-ups. The goal is to learn mo…

This study is creating a registry of 100 people with a rare type of lung cancer called ALK+ non-small cell lung cancer. Researchers will collect medical history, tumor tissue, and saliva samples to better understand the genetic and immune features of this cancer. The goal is to g…

This study is testing a new optical imaging tool that can look at tissue samples from the gut without destroying them. The goal is to see if this tool can help doctors detect diseases like those affecting the stomach and intestines. About 200 adults scheduled for routine endoscop…

This study was designed to see if quinine could be used as a marker to detect aspiration (leakage around the breathing tube) in critically ill patients on ventilators. Researchers planned to collect samples from the mouth and windpipe to measure quinine levels. However, the study…

This study was planned to see if giving nitric oxide gas during heart surgery changes levels of certain antioxidants in the blood. It was an add-on to a larger trial and would have included adults having heart surgery with a heart-lung machine. However, the study was withdrawn be…

This study is testing a new, high-resolution imaging device that goes through the nose to look at the small intestine. Researchers want to see if healthy adults and pregnant women in their second trimester can tolerate the device and if it can clearly show gut features. The goal …

This study tests a self-guided video program on a smartphone to see if it can reduce stigma and mistrust around mental health care for Black adults with depression or anxiety. About 90 participants aged 18-45 who haven't seen a therapist in the past year will use the app. The goa…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special scan to measure inflammation in the aorta. The study was withdrawn before enrol…

This study looks at how certain brain waves during sleep help us remember things. Researchers will play short bursts of sound at specific times to see if they can strengthen these brain waves and improve memory. The study involves 24 epilepsy patients who already have brain impla…

This study was designed to see if a website could help men with low-risk prostate cancer understand their treatment options and feel more confident in their choices. Researchers planned to give participants access to an educational website and then measure their knowledge and dec…

This study aims to gather information from adults with hand or upper arm issues, both from injuries and other causes. Researchers will use questionnaires to measure disability. The goal is to learn more about these conditions, not to test a new treatment.

This study tests a painless, noninvasive adhesive patch that collects skin cells from children's suspicious moles. Researchers will check for specific genetic markers (PRAME and LINC) and see if they match the results from a standard biopsy. The goal is to understand if this simp…

This study looks back at medical records of 50 people with mucolipidosis type IV (MLIV) to describe how the disease affects development, movement, and vision. Researchers want to learn when children reach or lose key milestones and how fast vision declines. No new treatments are …

This study looks at how transcranial magnetic stimulation (TMS) affects the brains of people with depression. Researchers use MRI scans to measure changes in brain connections. About 54 adults aged 18-80 who are already receiving TMS as part of their care will participate. The go…

This study looks at whether mild whole body heating can reduce depression symptoms by affecting the immune system. About 35 adults with major depression will receive either a drug that blocks an immune signal (IL-6) or a placebo before the heating session. The goal is to understa…

This pilot study tests whether allowing a slightly lower blood pressure after heart surgery (permissive hypotension) is safe and can reduce the need for blood-pressure-raising drugs. About 80 adults having planned heart surgery will be randomly assigned to either this approach or…

This study tests two new imaging devices—a tethered capsule and a thin nasal probe—to see if they can safely and comfortably take pictures of the small intestine in children with Environmental Enteric Dysfunction (EED), a gut condition linked to malnutrition. About 170 children a…

This study aimed to find the best level of breathing support (PEEP) for obese patients on ventilators to help them breathe on their own. It planned to test different PEEP levels during weaning from the ventilator. However, the study was withdrawn before enrolling any participants…

This study was designed to see if giving nitric oxide gas during heart surgery helps protect blood vessel function in patients with pre-existing vessel problems. It was an add-on to a larger trial and planned to measure blood flow changes in the arm. However, the study was withdr…

This study is looking for a better way to predict infection risk in people with chronic lymphocytic leukemia (CLL) or multiple myeloma (MM). Researchers will use advanced lab tests on blood samples from 150 adults to see if they can find a more precise marker. The goal is to help…

This study looks at how healthy adults process high doses of inhaled nitric oxide. Ten volunteers aged 18-64 will breathe up to 300 parts per million of the gas while researchers track changes in methemoglobin, a blood protein. The goal is to understand how fast methemoglobin for…

This study looks at whether using a laser followed by a medicated gel (NanoDOX) can help deliver medicine deeper into the skin and improve wound healing. Healthy adults will receive the laser treatment and gel on small skin areas, and biopsies will be taken to measure drug depth …

This study looks at whether a special blood test called TEG-PM can help doctors choose the right blood-thinning medicine for people who had leg artery surgery for peripheral artery disease (PAD). About 130 adults will have their blood tested before and after surgery, and their me…

This study tests whether playing soft sounds during sleep can help normalize brain activity and improve memory in people with schizophrenia. Researchers will compare sleep and memory in 70 participants (healthy adults and schizophrenia patients) during two naps—one with sounds an…

This study aims to see if a special camera pill can safely capture images of nerve damage in the esophagus of people with Parkinson's disease. About 20 adults with Parkinson's will swallow the pill, and researchers will compare the images to those from people without Parkinson's.…

This study looks at tiny pieces of genetic material (called extracellular RNA) in the blood of 400 people with congestive heart failure. Researchers want to see if these RNA levels can predict changes in heart structure and future serious events like hospital stays or death. Part…

This study checks if a Samsung smartwatch can identify people with major depressive disorder by tracking heart rate, sleep, and steps. About 220 adults (135 with depression, 85 healthy) will wear the watch for 3 months and answer daily surveys. The goal is to see if the watch's "…

This study is testing a special thermal probe that measures temperature changes in the colon wall during a routine colonoscopy. The goal is to see if this device can help detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative…

This study tests a new imaging method called DBT-TOBI, which combines a 3D mammogram with a light-based scan, to see if it can predict how well breast cancer responds to chemotherapy before surgery. About 30 women with HER2+ or triple-negative breast cancer will get scans before …

This study looks at fatty deposits called plaques that can build up in heart arteries and sometimes cause heart attacks. Researchers are using a new imaging method to see which plaques are 'vulnerable' and more likely to cause problems. About 320 people with coronary artery disea…

This study aimed to learn how the brain controls speech in people with Parkinson's disease who are getting deep brain stimulation (DBS). Researchers planned to record brain activity during DBS surgery while participants performed speech tasks. The goal was to gather data that cou…

This study looks at how a low dose of ketamine given through an IV can quickly improve depression and suicidal thoughts. Researchers will collect cells from the nose to study gene activity and use brain scans to see how ketamine changes brain connections. The goal is to find the …

This study tests whether a special pressure-enabled catheter delivers radioactive tracer more precisely to liver tumors than a standard catheter. Twenty adults with liver cancer who are scheduled for radioembolization will receive both catheters during the mapping procedure. The …

This study follows 240 teenagers and young adults aged 13-21 to see how weight-loss surgery (gastric bypass or sleeve gastrectomy) impacts bone density and strength over two years. It compares those who have surgery with overweight teens who do not. The goal is to understand if t…

This study follows two small groups of pregnant women in Bolivia living above 3,500 meters: healthy women and those with complications like preeclampsia. Researchers measure heart function, blood vessel changes, and baby growth to understand how high altitude affects pregnancy. T…

This study looks at whether measuring tobacco smoke exposure in children during routine blood draws can help parents quit smoking. About 865 parents of young children are taking part. The goal is to see if this approach boosts quit rates and makes tobacco treatment part of regula…

This study tests a new, pill-sized camera on a string (OFDI capsule) that people swallow while awake to take detailed pictures of the upper small intestine. Researchers want to see if it's comfortable and works well in 108 volunteers, including healthy adults and people with celi…

This study was designed to figure out why fractional CO2 laser treatment helps reduce pain and itch in burn scars. Researchers planned to take small skin samples from people with burn scars before and after laser treatment to look at nerve changes. The study was withdrawn before …

This study tests whether short, school-based conversations about alcohol can reduce drinking, cannabis, and nicotine use among high school students. About 21,000 teens across Massachusetts will take surveys over two years. The goal is to see if these programs work and can be deli…

This study follows 600 children and young adults (ages 2–25) who received radiation therapy for brain tumors or other cancers. Researchers want to understand how treatment affects their quality of life over time. The goal is to use this information to make future treatments bette…

This early-stage study tests whether low-intensity focused ultrasound applied to the amygdala can change brain activity and improve mood in people with bipolar disorder. Twenty adults with bipolar I or II will receive the ultrasound while researchers measure brain scans and mood …

This study was designed to find better ways to place deep brain stimulation (DBS) electrodes in patients with severe obsessive-compulsive disorder (OCD). The goal was to use brain scans to personalize targeting and improve symptom relief. However, the study was withdrawn before e…

This study looks at whether doing therapy in the morning or late afternoon changes how well people with PTSD overcome fear. 52 adults will receive 10 sessions of prolonged exposure therapy via telemedicine, either right after waking or after 4 PM. Researchers will measure fear re…

This early-stage trial enrolls 16 adults with recurrent IDH-mutant gliomas who are scheduled for surgery. Participants take niraparib for one month before their operation so researchers can measure how much drug reaches the tumor and how it affects cancer cells. The goal is to ga…

This study follows 500 adults with Barrett's esophagus, a condition where the lining of the food pipe changes, for 3 years. Researchers use a tethered capsule endomicroscopy device to take detailed images of the esophagus. The goal is to measure how the affected area changes over…

This study tests a new imaging method called OCT-NIRAF to see if it can predict how plaque builds up in heart arteries. About 40 adults with heart disease will get this special scan during a standard heart procedure, then a CT scan a year later. The goal is to learn if the new sc…

This study looks at whether giving patients extra decision-making tools helps them feel more satisfied and less conflicted about their treatment for common hand conditions like carpal tunnel syndrome or trigger finger. About 126 adults will be randomly assigned to receive either …

This study looks at whether a blood test that detects tiny bits of tumor DNA can help doctors decide when it's safe to stop immunotherapy in people with advanced melanoma or non-small cell lung cancer. About 39 patients who have been on immunotherapy for at least a year and show …

This study tests a special camera capsule that people swallow to take detailed pictures of the esophagus. It includes healthy volunteers and people with eosinophilic esophagitis (EoE). The goal is to see if the capsule works well and is comfortable enough to use in the future.

This study looks at tiny pieces of RNA in the blood of 200 adults hospitalized with acute congestive heart failure. Researchers want to see if these RNA levels change as patients receive treatment to remove excess fluid, and whether they can help predict who will improve. The goa…

This study looks at how common acquired pyruvate kinase deficiency is in people with certain blood cancers or pre-cancer conditions. Researchers will take a single blood sample from 100 participants to check for low enzyme activity or gene changes. The goal is to better understan…

This study aimed to see if tying off extra veins (side branches) could help dialysis fistulas grow strong enough to use. It was designed for adults whose fistulas were not maturing properly. However, the study was withdrawn before enrolling any participants, so no results are ava…

This study looks at whether specific genes influence how people respond to a meal and a single dose of metformin, a common diabetes medication. Over 1,000 adults without diabetes will eat a special test meal and take metformin to measure changes in blood sugar and insulin. The go…

This study looks at how people with cancer-related pain take their long-acting opioid medications. The goal is to learn what works and what doesn't, so researchers can create a better way to manage cancer pain. About 150 adults who are already prescribed these pain medicines will…

This study looks at how problems with the body's internal clock (circadian rhythm) may cause REM sleep behavior disorder, where people physically act out their dreams. Researchers will measure sleep patterns and hormone levels in 30 adults recently diagnosed with the condition. T…

This study looks at whether proton beam radiation causes less damage to the heart than standard photon radiation in people with left-sided breast cancer. About 60 participants will receive either proton or photon therapy, and their hearts will be checked with MRI scans. The goal …

This study looks at 100 people with stage II or III breast cancer who are already getting radiation. It compares proton beam radiation to standard X-ray radiation to see which one causes less damage to the heart and lungs. The goal is to learn which type of radiation is safer, no…