Massachusetts General Hospital

This study is testing a more precise type of radiation called proton therapy for adults with certain slow-growing brain tumors. The goal is to see if it can control tumor growth as well as standard radiation while causing fewer side effects by limiting radiation exposure to healt…

This study is testing an experimental brain implant that stimulates two connected brain areas to treat severe obsessive-compulsive disorder (OCD) that hasn't improved with standard therapies. Only 2 participants with extremely severe, long-lasting OCD symptoms will receive the im…

This study is testing whether a short course of two targeted cancer drugs (trametinib and dabrafenib), given alongside an immunotherapy drug (pembrolizumab), works better than expected for people with advanced melanoma that cannot be removed by surgery. The goal is to see if this…

This is an early-stage study testing whether two targeted cancer drugs, dabrafenib and trametinib, can help control multiple myeloma that has returned or stopped responding to other treatments. The trial is for up to 30 adults whose cancer cells have specific genetic changes (BRA…

This study is testing whether transplanting gut bacteria from a healthy donor can improve thinking problems in people with advanced liver disease, a condition called hepatic encephalopathy. Researchers will first find the best stool donors and then give capsules containing their …

This study is testing if a blood test that looks for tiny pieces of cancer DNA can help doctors decide when it might be safe for patients to stop their immunotherapy. It involves 39 people with advanced melanoma or non-small cell lung cancer whose cancer is under control after at…

This study aimed to improve deep brain stimulation (DBS) treatment for severe obsessive-compulsive disorder (OCD). Researchers wanted to use advanced brain imaging to help surgeons place the stimulation device more precisely in each patient's unique brain anatomy. The goal was to…

This study is testing whether the drug eribulin can help control two rare types of blood vessel cancers: angiosarcoma and epithelioid hemangioendothelioma (EHE). The trial involves adults whose cancer has continued to grow despite previous treatments. Researchers want to see if t…

This study aims to see if proton beam radiation causes less heart damage than traditional photon radiation for people with left-sided breast cancer. Researchers will randomly assign 60 participants to receive either proton or photon radiation and use heart MRI scans to measure sc…

This study is testing whether a specific type of talk therapy (CBT-AR) combined with nutrition counseling can help children and teenagers with Avoidant/Restrictive Food Intake Disorder (ARFID). Researchers will measure changes in eating behaviors, food fears, and brain activity i…

This early-stage trial is testing whether adding an experimental drug called ipatasertib to standard hormone therapies can help control metastatic breast cancer that has stopped responding to previous treatments. The study will enroll 77 postmenopausal women to determine if the c…

This study is testing a more precise form of proton radiation therapy, sometimes combined with surgery, to control rare bone tumors in the spine, tailbone, and base of the skull. The goal is to see if this advanced technique can better target the cancer while reducing damage to h…

This early-stage study is testing the safety of a three-part treatment given before surgery for soft tissue sarcoma. The treatment combines a targeted drug (bevacizumab), a chemotherapy (doxorubicin), and radiation therapy. The main goal is to find the highest safe dose of bevaci…

This study is testing whether taking the drug ruxolitinib after a stem cell transplant can help prevent cancer from returning in older patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The trial involves 64 participants aged 60-80 who have achieved rem…

This trial is testing if digoxin, an FDA-approved heart medication, is safe and tolerable for people with early ALS (within 2 years of symptoms). It will also check if the drug can slow the progression of nerve damage by measuring a specific blood protein. The study involves 40 p…

This early-stage study is testing the safety of a new cancer vaccine (PVX-410) combined with other drugs for people with smoldering multiple myeloma, an early form of blood cancer. The goal is to see if these combinations can safely boost the immune system to fight the cancer cel…

This early-stage study is testing the safety and best dose of an experimental drug called AZD6738 for adults with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) that has progressed after initial treatment. The drug works by blocking a specific protein in…

This large study aims to find the best medication strategies for adults with bipolar disorder who are experiencing a depressive episode. It will compare four common treatment approaches, including three FDA-approved medications and one widely used combination. If a person's first…

This study is testing whether Truvada, an antiviral medication, can reduce levels of Epstein-Barr virus (EBV) in people with multiple sclerosis (MS). Researchers believe EBV might trigger MS, so lowering the virus could help control the disease. The trial will enroll 50 adults wi…

This study is testing whether adding high-dose omega-3 fish oil supplements to standard antidepressant medication can help people with depression that hasn't fully responded to treatment. Researchers want to see if the supplements reduce body inflammation and if that reduction is…

This study is testing a new approach for people who have received a kidney transplant. After the kidney transplant, patients get a bone marrow transplant from the same donor. The goal is to 're-educate' the patient's immune system to accept the new kidney, potentially allowing th…

This study aimed to test whether adding two immunotherapy drugs (domvanalimab and zimberelimab) to standard chemotherapy could better control cancer in people with operable stomach or esophageal cancer. Patients would have received the drug combination for about 4 months before s…

This study is testing whether the drug ruxolitinib can help people who develop lung scarring (Bronchiolitis Obliterans Syndrome) after a stem cell transplant. The trial will enroll 50 adults to see if the medication improves their breathing and controls the underlying graft-versu…

This study is testing a Spanish-language text message program designed to help Latino adults with type 2 diabetes remember and feel better about taking their medications. Researchers are working with 70 participants to see if the text tool is easy to use and helpful. If successfu…

This study is testing a specialized type of radiation called proton therapy for treating a non-cancerous brain tumor called an acoustic neuroma. The goal is to see if this more targeted radiation can better preserve patients' hearing while still controlling the tumor's growth. Re…

This study is testing a new combination of four drugs for people newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. The goal is to see how well this weekly treatment regimen controls the cancer and leads to deep remission. About 50 participants wil…

This study is testing whether adding a second drug, cobimetinib, to the standard drug alectinib can help control advanced lung cancer that has stopped responding to alectinib alone. Researchers want to find the safest dose of this combination and see if it can shrink tumors or sl…

This study is testing if a simple wireless monitor can help save mothers' lives after a C-section. Over 3,100 women in Uganda who had emergency C-sections wore the monitor for 24 hours after delivery. The system alerts doctors via text message if a mother's vital signs become dan…

This study is testing whether giving the BCG vaccine multiple times over four years can help people with established Type 1 diabetes. Researchers believe the vaccine might eliminate harmful immune cells that attack the pancreas, potentially allowing it to produce more insulin nat…

This study aims to understand how a single session of mild whole-body heating might help reduce symptoms of major depression. Researchers are testing 35 adults with depression to see if the treatment works and to learn more about how it affects the body's immune system. The study…

This study is testing a custom-made genetic medicine for a single child with a severe, rare brain disease called TUBB4A leukodystrophy. The goal is to see if the personalized treatment is safe and can help control the disease by improving the child's movement, development, and qu…

This early-stage study is testing the safety of a new cancer vaccine called PVX-410, given alone and with an immunotherapy drug (pembrolizumab), in 20 patients with advanced triple-negative breast cancer. The goal is to see if the combination can safely help the patient's own imm…

This study is testing if adding a drug called infliximab to standard immunotherapy helps people with advanced melanoma. The goal is to see if this combination can better control the cancer while also reducing the severe digestive side effects that immunotherapy sometimes causes. …

This study is testing whether calcitriol (a form of vitamin D) given alone for one year can help people with X-linked hypophosphatemia (XLH), a rare genetic disorder that causes weak bones and poor growth. The research involves 20 children and adults with XLH and will measure cha…

This study is testing a more precise form of radiation therapy (proton therapy) for children with brain tumors that require radiation to the brain and spine. The goal is to see if this method can protect the bones and bone marrow in the spine, aiming to reduce side effects like g…

This study is testing whether a gentle, non-invasive electrical stimulation of a neck nerve (called the vagus nerve) can improve memory and thinking skills in older adults. Researchers will give the stimulation to about 140 participants and measure changes in their ability to rem…

This pilot study is testing whether allowing slightly lower blood pressure after heart surgery is safe and beneficial. It will compare two groups: one where blood pressure is kept just above 60 mmHg and another receiving standard care. The goal is to see if this approach reduces …

This study is testing if a new type of catheter can better target radiation to liver tumors during a standard treatment called radioembolization. About 20 adults with liver cancer will have their standard treatment planning scan done with either the new device or a standard cathe…

This study tested whether the immunotherapy drug pembrolizumab could help control aggressive brain tumors called high-grade meningiomas that have returned or persisted after previous treatments. The trial involved 26 adults whose tumors showed signs of progression. Researchers mo…

This study follows patients with hereditary hemorrhagic telangiectasia (HHT) who previously participated in a trial testing pomalidomide for bleeding control. Researchers are tracking these patients over time to understand the long-term safety and effectiveness of the treatment. …

This study is testing whether a three-part treatment is safe and can help control advanced triple-negative breast cancer that has spread and hasn't responded well to standard immunotherapy. The treatment combines two drugs—one that helps the immune system fight cancer and another…

This study tests whether the drug infliximab works better than standard steroid treatment to control severe colon inflammation (colitis) caused by cancer immunotherapy drugs. The trial involves 42 adults with advanced skin cancer who developed this serious side effect while recei…

This study is testing whether adding a newer drug, lurbinectedin, to a standard chemotherapy (doxorubicin) works better for treating advanced soft-tissue sarcoma. The first part checks the safety and best dose of the combination. The second part directly compares the new combinat…

This study is testing if adding nutrition education to an existing high blood pressure support program helps people eat healthier and better control their blood pressure. It involves 60 adults with high blood pressure who also struggle to afford healthy food. Participants are ran…

This early-stage study is testing a new treatment approach for people receiving a kidney transplant from a living donor. The goal is to see if a special conditioning regimen can safely mix the donor's and recipient's immune systems, potentially allowing the body to accept the new…

This early-stage study is testing a new three-drug combination for multiple myeloma that has returned or stopped responding to prior treatments. The main goal is to find the highest safe dose of the new drug, sotatercept, when given with two existing medications. Researchers will…

This study is testing whether adding the drug hydroxychloroquine (used for malaria and arthritis) to the cancer drug erlotinib helps control advanced non-small cell lung cancer for a longer period. It involves 76 adults with a specific genetic mutation in their cancer who have no…

This study is testing whether adding two drugs, losartan and nivolumab, to standard chemotherapy and radiation can better shrink pancreatic tumors before surgery. The goal is to help surgeons completely remove the cancer and improve patient outcomes. It is for adults with localiz…

This study is testing whether vedolizumab, a medication given through an IV, can help control symptoms of collagenous gastritis—a rare stomach condition. Eleven participants aged 14+ with confirmed diagnosis and symptoms will receive infusions and be monitored for symptom changes…

This study is testing whether the drug niraparib can help control cancer that has spread to the brain or spinal cord. It will involve about 20 adults whose cancer has specific genetic changes and has progressed despite other treatments. Participants will take the oral medication …

This early-stage study is testing a new vaccine (PVX-410) alone and combined with an immunotherapy drug (durvalumab) for women who have already finished standard treatment for stage II or III triple-negative breast cancer. The main goals are to check if the treatments are safe an…

This study aims to compare how well two different FDA-approved osteoporosis medications work to strengthen bones in postmenopausal women at high risk of fractures. Researchers will follow 50 participants for 12 months, measuring changes in hip bone density. The goal is to help do…

This was an add-on study to a larger trial testing if breathing nitric oxide gas during and after heart surgery helps protect patients' blood vessels. It focused on patients with existing blood vessel problems who were having long surgeries using a heart-lung machine. The goal wa…

This study aims to see if proton beam radiation causes fewer side effects to the heart, lungs, and other nearby organs compared to standard radiation for people with stage II or III breast cancer. It follows 100 patients who are already part of a larger trial comparing the two ra…

This study is testing the safety of a drug called niraparib when given alongside standard radiation therapy after surgery. It involves 21 adults with triple-negative breast cancer who still have some cancer cells left after initial treatment. The goal is to see if this combinatio…

This study is testing whether combining four already-approved drugs works better together for people with multiple myeloma that has returned or stopped responding to other treatments. It will involve about 52 adults whose cancer has progressed despite previous therapies. The main…

This study is testing a new support program for young adults (ages 18-30) with type 1 or type 2 diabetes as they move from pediatric to adult healthcare. Researchers will compare this new program to standard care to see if it helps people keep doctor's appointments and reduces th…

This study is testing whether combining two immunotherapy drugs (nivolumab and ipilimumab) with targeted radiation can help control advanced colorectal or pancreatic cancer. The goal is to see if this three-part approach can help the body's own immune system better recognize and …

This study is testing whether adding a drug called ribociclib to standard hormone therapy can better prevent early-stage, hormone-sensitive breast cancer from returning. It is for patients who have completed initial surgery and have a specific marker of very low-level cancer in t…

This study is testing whether a type of radiation called proton beam therapy can effectively treat germ cell tumors in the brain or spine while causing fewer side effects than standard radiation. It involves 45 participants aged 3 to 25 who have this type of tumor. The main goal …

This early-phase study is testing whether intravenous methylphenidate (a stimulant) can safely help restore brain network connections in patients with severe disorders of consciousness, such as coma or vegetative state, following traumatic or anoxic brain injury. The trial will e…

This study compares two radiation treatments for early-stage prostate cancer to see which causes fewer side effects. Researchers are testing whether proton beam therapy (PBT) causes fewer bowel, urinary, and sexual problems than standard radiation (IMRT). The study involves 454 m…

This study is testing whether two special diets can help people with active Crohn's disease or ulcerative colitis. Forty adults will follow either a partial liquid elemental diet or a specific carbohydrate diet for six weeks. Researchers will check if the diets reduce gut inflamm…

This study is testing whether a more focused, higher-dose form of proton radiation can better control aggressive brain tumors called meningiomas. It involves 21 adults with specific types of these tumors that have been partially or fully removed by surgery. The main goal is to fi…

This is a small, early-stage study testing a new treatment approach for liver cancer that can be removed by surgery. Researchers want to see if giving a combination of targeted radiation and two immunotherapy drugs *before* the operation is safe and might help the body's immune s…

This early-stage study is testing whether giving monthly injections of an FDA-approved drug called Kybella (deoxycholate) can safely reduce the size and improve the appearance of skin tumors in adults with Neurofibromatosis Type 1. Researchers will treat up to 50 tumors in a sing…

This study is testing whether delivering a precise, high dose of radiation directly to the tumor during surgery can help control pancreatic cancer in patients whose tumors involve major blood vessels. Participants first receive 3-6 months of chemotherapy and external radiation, t…

This study aimed to see if doing arm exercises while taking a bone-building medication (PTH) could improve bone density in the forearm. It was designed for postmenopausal women over 45 with osteoporosis and a high risk of fractures. The trial was withdrawn before any participants…

This study aims to find out which treatment works better for painful hip labral tears in adults aged 40 and older: arthroscopic surgery or physical therapy. Researchers are enrolling 110 participants to compare pain relief, hip function, and quality of life over 12 months. The go…

This study is testing whether artificial intelligence (AI) can help doctors better diagnose functional gastrointestinal disorders (FGIDs), like IBS. Researchers will use AI to analyze recordings of 700 patients describing their symptoms during clinic visits or before an endoscopy…

This study is testing whether an artificial intelligence (AI) tool can use simple, at-home heart tests to find people who are more likely to have an undiagnosed irregular heartbeat called atrial fibrillation (AF). Researchers will mail a small heart monitor to 200 participants to…

This study is testing a new, swallowable imaging capsule to see if it can take clear pictures of the inside of the esophagus (the food pipe). The goal is to see if this method is comfortable for people and works well enough to help doctors spot signs of a condition called Eosinop…

This study is testing whether a small, swallowable capsule attached to a thin string can effectively screen for Barrett's esophagus in primary care clinics. The capsule takes microscopic pictures of the esophagus during a 10-minute procedure without sedation. Researchers want to …

This study is testing new, less invasive ways to look inside the small intestine of children and pregnant women in Pakistan who have a gut condition linked to malnutrition and stunted growth. Participants will swallow a small, pill-sized camera on a string or have a thin tube pas…

This study is testing a new swallowable camera capsule to see if it's comfortable and works well for taking pictures of the small intestine. Researchers want to see if this method can help doctors better examine the gut in people with celiac disease. The study involves 108 people…

This study is testing if a new type of combined PET/MRI scan can better find and classify endometriosis. It will compare the new scan to current standard methods like MRI, ultrasound, and surgery in 60 patients scheduled for laparoscopic surgery. The goal is to see if this scan c…

This study aimed to test a new, swallowable camera capsule to diagnose conditions like eosinophilic esophagitis (EoE). The goal was to see if images from the capsule were as good as those from standard, invasive biopsy procedures that require sedation. The trial was withdrawn bef…

This study is testing a new device called the LymphaTech Scanner to see if it can effectively and quickly detect early signs of arm swelling (lymphedema) in people treated for breast cancer. Researchers will compare it to the current standard device (Perometer) by measuring arm v…

This study is testing a small, swallowable camera capsule that takes detailed pictures of the esophagus to help doctors better identify and mark areas of Barrett's Esophagus. Participants will swallow the capsule while awake, then undergo their standard endoscopy procedure. Resea…

This study aimed to see if giving a short course of the drug amiodarone right after heart surgery could safely prevent a common complication called postoperative atrial fibrillation (an irregular heartbeat). It planned to test this in adults having certain types of heart surgery …

This study is testing whether a single dose of the HPV vaccine can prevent new HPV infections in women who are living with HIV and have already received HPV vaccination in the past. Researchers are comparing giving the HPV vaccine immediately versus after an 18-month delay in 778…

This study is testing whether taking a daily low-dose aspirin pill can help prevent colorectal cancer in people who have had precancerous polyps removed. About 160 participants will take either aspirin or a placebo pill daily for a set period while researchers analyze blood, urin…

This study aims to find the best way to prevent dangerous blood clots in patients having surgery for bone or soft tissue cancer in the leg or pelvis. It will compare two common prevention methods: daily aspirin pills versus daily blood-thinner injections (LMWH). Researchers want …

This study is testing different school-based alcohol prevention programs across Massachusetts high schools. Researchers want to see if starting prevention earlier and using trained school staff (not just nurses) can help reduce risky drinking and improve mental health in teenager…

This study is testing whether offering health services in hair salons makes it easier for women to access important preventive care. Researchers are providing HIV prevention medication (PrEP), birth control options, and STI screening in two salons in Umlazi, South Africa, while c…

This study is testing whether taking a daily aspirin pill can help prevent colorectal cancer in people who are at higher risk because they've had precancerous polyps removed. Researchers are comparing a low-dose aspirin, a regular-dose aspirin, and a placebo (sugar pill) in 180 a…

This study is testing if a special group program can help prevent eating disorder thoughts and behaviors from coming back during pregnancy and after birth. It's for pregnant people who have had an eating disorder in the past. The program is compared to general health education cl…

This study is testing a counseling program called TENDAI4PrEP, designed to help pregnant women in Zimbabwe start and continue taking medication to prevent HIV. The program works with women, their partners, and healthcare providers to solve problems that make it hard to take the p…

This study is testing whether delivering HIV prevention medication (PrEP) directly to people in their communities is more effective than requiring them to visit clinics. It involves 2,500 young women and men in South Africa who are at high risk for HIV. The goal is to see if this…

This study aimed to test if a new mobile app could help prevent depression and anxiety in pregnant women. It planned to enroll women in their second or third trimester to use the app's mental wellness program. The goal was to see if easy-to-access digital tools could reduce the r…

This study is testing if a new approach helps parents who smoke quit. When a child gets a blood test, researchers check it for a toxin from tobacco smoke. Parents are shown their child's result and offered quitting support. The goal is to see if this personal feedback leads more …

This study is testing whether a medication called pramipexole can help women with X-linked adrenoleukodystrophy (ALD) who suffer from restless legs syndrome. The research aims to see if the drug reduces leg discomfort, improves sleep quality, and helps with walking ability. The t…

This study is testing whether monthly treatments with a specific type of laser can safely reduce the size and improve the appearance of skin tumors in adults with Neurofibromatosis Type 1 (NF1). Researchers will give up to six laser treatments and measure changes in the tumors, p…

This study is testing two different virtual group programs to help older adults who have both chronic pain and early signs of memory decline. The programs aim to improve physical function, thinking skills, and emotional well-being through guided sessions. Researchers want to see …

This study aimed to find the best air pressure setting to help severely obese patients breathe on their own after being on a ventilator. Researchers tested if a personalized pressure level could make breathing easier and help patients get off the ventilator successfully. The tria…

This study aimed to test if a very low dose of a specific pain medication (buprenorphine/naloxone) could help manage pain after surgery for people who already regularly use opioid painkillers. It planned to compare this approach to standard pain management to see if it reduced pa…

This study is testing whether a mobile phone app called 'Horizons' can help people who are living with chronic graft-versus-host disease (GVHD) after a stem cell transplant. About 120 adult patients will be randomly assigned to either use the app along with their usual care, or t…

This study is testing whether daily exposure to bright light can help improve sleep quality and reduce daytime sleepiness in people with Parkinson's disease. Researchers will measure sleep patterns, alertness, and body clock signals in 65 participants. The goal is to see if this …

This study is testing whether listening to calm, symphonic music for 30 minutes can help patients feel better after heart surgery. Researchers will compare 120 patients who listen to music to those who receive standard care, measuring stress hormones, anxiety, pain, and vital sig…

This study aimed to find the best way to manage pain after surgery for people taking buprenorphine for opioid addiction. Researchers planned to compare continuing the full medication dose versus temporarily lowering it around surgery time. The goal was to see which approach bette…

This study is testing a new support program called 'Resilient Families' for parents whose babies are in the Neonatal Intensive Care Unit (NICU). The program involves six video sessions with a psychologist to teach coping and communication skills. It aims to reduce parents' emotio…

This study is testing if a special type of exercise training can help people recover faster after surgery for a torn Achilles tendon. The training uses a personalized tourniquet to briefly restrict blood flow to the calf during low-intensity exercises. Researchers will compare th…

This study is testing whether a special type of parent-child therapy, delivered remotely, can help reduce anxiety in very young children (ages 2-3) who show high levels of fear or shyness. Researchers are working with 90 families to see if this early intervention is practical and…

This study is testing whether a 12-week online group yoga program works as well as a proven online behavioral therapy for reducing depression symptoms in adults. Over 500 participants with depression were randomly assigned to receive either yoga or therapy sessions, with their sy…

This small study is testing whether monthly video calls with palliative care specialists are a practical and helpful way to support adults with moderate to severe chronic graft-versus-host disease (cGVHD). The goal is to help patients better manage their complex symptoms, reduce …

This study is testing if virtual coaching sessions can help childhood cancer survivors better understand their health insurance. The goal is to reduce their financial stress and worry about medical bills, and help them get the healthcare they need. Researchers are comparing live …

This study is testing whether adding an online platform to a standard 8-week exercise program helps older Black adults stay active and improve their health. Researchers are comparing the standard program alone to the program plus the online tool across four community centers or c…

This study is testing whether a mobile app can improve the well-being of people caring for loved ones undergoing bone marrow transplants for cancer. About 120 caregivers will either use the CARE app along with standard support or receive standard support alone. Researchers will m…

This is a small, early-stage study to see if a new virtual mind-body program is practical and acceptable for people with long-term hip pain. Five adults with chronic hip pain will try a 6-week program of online sessions with a physical therapist, learning relaxation and coping sk…

This study is testing a new support program designed to help adults who have had a stem cell transplant for blood cancer with sexual problems that are causing distress. About 120 participants will be randomly assigned to receive either this specialized program or standard educati…

This study is testing if a virtual group support program can help adults who developed a serious complication called chronic Graft-Versus-Host Disease (GVHD) after a stem cell transplant. The program aims to improve their quality of life, help them cope with symptoms, and manage …

This study is testing whether a home-based brain stimulation device can help improve thinking problems like brain fog, poor concentration, and slow processing speed in people with long COVID. Participants use a non-invasive device that delivers a mild electrical current to the sc…

This study is testing if a team-based clinic can improve the daily life and physical function of people living with a mechanical heart pump (VAD). It will involve 110 patients and their caregivers, comparing new team care to standard visits. The goal is to see if this approach le…

This study is testing ways to better support parents and caregivers who take children with tracheostomies home from the hospital. Researchers are comparing a standard discharge program to an enhanced version with extra support. They want to see if the extra help reduces caregiver…

This study is testing whether cognitive behavioral therapy (CBT), a common talk therapy, is effective when provided by supervised but unlicensed trainees. It aims to see if this approach can help more people get access to proven mental health treatments for conditions like anxiet…

This study is testing two different 8-week online group programs designed to help teenagers with neurofibromatosis (NF1 or NF2) manage stress and symptoms. The programs are delivered via secure video chat and aim to improve emotional well-being, social skills, and physical comfor…

This study is testing a mobile phone app called THRIVE-M, designed to help people with multiple myeloma cope with the emotional and physical challenges of their illness. It will compare the app's effects on quality of life, distress, and fatigue against standard care in 120 parti…

This study is testing whether adding a specialized palliative care team to standard cancer treatment improves the experience for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The palliative care team focuses on managing pain, fatigue, anxiety, and …

This study is investigating whether melatonin, a common sleep aid, affects specific brain waves called sleep spindles in teenagers with autism. Researchers are observing 30 participants to see if changes in these brain waves relate to sleep quality and sensory sensitivities. The …

This study aims to understand if a disrupted internal body clock (circadian rhythm) plays a role in causing REM sleep behavior disorder (RBD), a condition where people physically act out their dreams. Researchers will measure sleep patterns, hormone levels, and daytime sleepiness…

This study aims to understand how sleep helps memory and if playing quiet, timed sounds during sleep can improve it. It involves 24 epilepsy patients who already have special electrodes implanted for medical monitoring. Researchers will measure brain activity and test memory afte…

This study aims to understand how two common types of weight-loss surgery affect bone density and strength in teenagers and young adults with severe obesity. Researchers are following 120 participants aged 13-21 for two years, comparing those who have surgery to a similar group w…

This study aims to develop and test a remote monitoring system for people with frontotemporal dementia and related disorders like Progressive Supranuclear Palsy (PSP). Researchers will enroll 60 participants with PSP and follow them for 12 months using wearable sensors and mobile…

This was an add-on study to a larger trial testing nitric oxide gas in heart surgery patients. It aimed to understand the biological mechanisms—specifically how nitric oxide affects oxidative stress levels in the blood—that might explain why the gas could help reduce post-surgery…

This study aimed to understand why laser treatment helps reduce pain and itch in raised burn scars. Researchers planned to examine tiny skin samples from people undergoing standard laser therapy to see how nerves in the scar tissue change. The goal was to link these physical chan…

This study uses brain scans to understand how TMS (transcranial magnetic stimulation) treatment affects brain connections in people with depression. Researchers will scan participants' brains before and after they receive standard TMS treatment for their depression. The goal is t…

This study is investigating how a gentle electrical stimulation device placed on the ear might affect the brain circuits involved in stress for people with major depression. Researchers are testing the device during a brain scan to see if it changes brain activity and heart rate …

This study is testing a new, less invasive biopsy tool called a cryobiopsy probe. Researchers want to see if it works as well as the standard method for collecting small tissue samples from the gut. The long-term goal is to use this tool to better understand a serious childhood g…

This study aims to learn more about a dangerous type of fatty buildup in heart arteries called 'vulnerable plaque,' which is linked to heart attacks. Researchers will use a new, detailed imaging camera during a standard artery-opening procedure to see this plaque and watch for ch…

This study aims to create a detailed registry of 500 adults with functional GI disorders like IBS and chronic constipation. Researchers will collect health information, diet and lifestyle details, and biological samples to understand what causes these conditions. The goal is to b…

This study is testing whether a new imaging technique called OCT-NIRAF can help doctors better understand plaque buildup in heart arteries. Researchers will use this special imaging during heart procedures on 40 participants with heart disease, then check for plaque changes one y…

This study aimed to better understand how severe obesity affects pressures inside the chest during breathing. Researchers planned to compare measurements from two small groups of people: those with severe obesity and those with a normal weight. The goal was to gather basic knowle…

This study aimed to collect information from adults with hand or arm injuries or conditions to better understand these problems and improve future care. It planned to gather data on how these issues affect people's daily activities using a standard questionnaire. The study was wi…

This study aims to understand how specific genes influence how the body processes food and responds to metformin, a common diabetes medication. Researchers are enrolling 1,017 adults to eat a special test meal and take a single dose of metformin, then measuring blood sugar and ot…

This early study aims to understand if an experimental drug called niraparib reaches brain tumor tissue effectively. It involves 16 adults with recurrent, slow-growing brain tumors (gliomas) who are already scheduled for surgery. Researchers will measure how much of the drug gets…

This study aims to see if special decision-making tools help patients with common hand conditions feel less stressed and more satisfied when choosing treatments. Researchers will compare 126 patients who use these tools to those who receive standard information. The goal is to un…

This study aims to understand how a high dose of inhaled nitric oxide gas affects blood chemistry in healthy people. Ten volunteers will breathe the gas for short periods over five days while being closely monitored. The goal is to gather safety data on how the body forms and cle…

This study aims to find a more precise blood test to predict which patients with chronic lymphocytic leukemia or multiple myeloma are at highest risk for getting infections. Researchers will analyze blood samples from about 150 adults with these cancers over two years, looking fo…

This study aims to better understand how Barrett's Esophagus changes over a 3-year period. Researchers will follow 500 participants at five US medical centers using a special swallowable capsule with a tiny camera to take images of the esophagus. The goal is to track the size and…

This study aims to understand how memory works in the brains of people with early psychosis. Researchers will use a non-invasive magnetic stimulation device (TMS) and MRI brain scans on 20 participants. The goal is to gather knowledge about brain connections, not to provide treat…

This study aims to understand how tiny genetic signals in the blood change when people are treated for sudden, severe heart failure. Researchers will track 200 hospitalized patients, taking blood samples during and after treatment to see if these signals can show who responds wel…

This research aims to understand how electrical stimulation of a deep brain area called the thalamus affects natural sleep patterns. The study involves about 50 patients with epilepsy who already have electrodes implanted in their brains for medical monitoring. By carefully timin…

This project is creating a large database of heart scan images from 1000 patients who had multiple types of imaging tests. The goal is to collect these images so researchers can study them later to better understand how artery plaque (atherosclerosis) develops and causes heart pr…

This study aims to find early signs that might predict autism in babies who have a sibling with autism. Researchers will follow 600 infants for their first three years of life, collecting samples like stool, blood, and saliva to look for patterns. The goal is to better understand…

This study aims to learn more about how the brain works during speech and movement in people with Parkinson's disease who are undergoing deep brain stimulation (DBS) surgery. Researchers will record brain activity during the procedure to gather data. The goal is to use this infor…

This study is investigating whether the time of day a person receives therapy affects how well it works for Post-Traumatic Stress Disorder (PTSD). It involves 52 adults with PTSD who will receive a standard 10-session therapy called Prolonged Exposure, delivered via video call. H…

This study is testing a new, thin camera device that doctors can gently guide through the nose and into the small intestine. Researchers want to see if the device is comfortable for people and if it takes clear pictures. The results will help plan a future study to look for signs…

This study is testing a new method to help medicine get deeper into the skin to improve wound healing. Healthy volunteers will have a small laser treatment on their skin, followed by a special antibiotic gel. Researchers will take tiny skin samples to see how deep the medicine go…

This study aims to understand how different amounts of a non-invasive brain stimulation technique affect attention, memory, and brain activity in adults with ADHD. It involves 104 participants, including both people with ADHD and healthy volunteers. The research is measuring how …

This study aims to understand if gut problems in Parkinson's disease are linked to visible changes in the nerves of the esophagus. Researchers will test a new, swallowable camera that takes microscopic pictures of the esophagus in 20 people with Parkinson's. The goal is to see if…

This study aimed to find out which hospital treatments work best for people with severe, life-threatening skin reactions like Stevens-Johnson Syndrome. It planned to compare different medical approaches by tracking how quickly patients healed, how long they stayed in the hospital…

This study is testing a home smell test kit to see if it can reliably track how people's sense of smell recovers after a COVID-19 infection. Researchers will send smell cards to 1,000 participants, including people who lost their smell from COVID, healthy people, and those with o…

This study is testing if showing a short video about future medical care planning to patients in the emergency room makes a difference. It involves 900 people aged 65+ or those over 50 with a serious illness. The goal is to see if the video helps patients have better conversation…

This study aimed to test if quinine, a safe compound found in tonic water, could be used as a marker to detect leaks around breathing tubes in critically ill patients on ventilators. The goal was to find a better way to spot when fluids from the mouth leak past the tube's seal in…

This study aimed to understand how powerful cholesterol-lowering drugs (PCSK9 inhibitors) affect inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation in participants already on standard statin medicat…

This study aims to understand the long-term results of surgery for serious arm injuries and joint conditions. Researchers will follow 750 patients who have finished their standard medical care to see how well they recover over time. They will measure arm movement, function, pain …

This study aims to better understand how Barrett's esophagus changes over time. Researchers will follow 100 participants for three years using a special swallowable camera that takes images of the esophagus. The goal is to gather detailed information about the natural progression…

This study is testing new, non-destructive camera technology to take very detailed pictures of gut tissue samples. Researchers will compare these pictures to standard lab results to see if the technology can help identify diseases. The goal is to develop better tools for future d…

This study aims to find out how common a specific enzyme problem is in people with certain blood cancers and unexplained anemia. Researchers will take one blood sample from about 100 participants who have conditions like myelodysplastic syndrome (MDS) or other related disorders. …

This study aims to understand if certain molecules in the blood can predict how a patient's heart changes and whether they will have serious health events. Researchers will follow 400 people with heart failure during their regular outpatient treatment. They will track blood marke…

This study is testing a new tool—a thin probe inserted through the nose—to measure the health of the gut lining. Researchers want to see if this device can safely and accurately detect changes in 'gut permeability,' which is linked to conditions like Crohn's disease. The study in…