New combo aims to tackle Hard-to-Treat breast cancer
NCT ID NCT04837209
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining two drugs (niraparib and dostarlimab) with radiation therapy is safe and effective for people with metastatic triple-negative breast cancer that has not responded to immunotherapy or is PD-L1 negative. About 32 adults with this aggressive cancer will receive the combination treatment. The goal is to see if the tumors shrink or stop growing.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States
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Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
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University of Pennsylvania Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States