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New hope for AML: gentler pill combo could replace harsh chemo

NCT ID NCT04801797

Ongoing Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether a combination of two drugs, venetoclax (a pill) and azacitidine (an infusion), works better than standard intensive chemotherapy for adults newly diagnosed with acute myeloid leukemia (AML). The study enrolls 172 fit adults and measures how long they live without the cancer getting worse. The goal is to find a treatment that is both effective and less toxic than traditional chemo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Venetoclax and azacitidine (oral and intravenous drugs)
What this could lead to
If this works, it could offer a less toxic, more effective first treatment for fit adults with acute myeloid leukemia, potentially improving survival without the harsh side effects of standard chemotherapy.
What could go wrong
This is a mid-stage trial with 172 people, so results are not definitive. The new combo might not work better than standard chemo, and there are risks like infection or tumor lysis syndrome.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

  • Atrium Health Levine Cancer Institute

    Charlotte, North Carolina, 28204, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • City of Hope

    Duarte, California, 91010, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

  • Ohio State University Medical Center

    Columbus, Ohio, 43210, United States

  • Stanford Cancer Center

    Palo Alto, California, 94304, United States

  • University of California - Davis

    Sacramento, California, 95817, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.