New pacemaker technique aims to prevent heart damage

NCT ID NCT05869500

Ongoing Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 14, 2026 · Updated 4 times

Summary

This study compares a newer pacing method called left bundle branch area pacing (LBBAP) with standard right ventricular pacing in 100 adults who need a pacemaker but have normal heart function. The goal is to see if LBBAP better prevents the decline in heart pumping ability that can occur with standard pacing. Participants will be randomly assigned to receive one of the two pacemaker types and followed for changes in heart function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Left bundle branch area pacemaker (device) vs. right ventricular pacemaker (device)
What this could lead to: If successful, this could show that left bundle area pacing is a better standard option for preventing heart damage in people who need a pacemaker.
What could go wrong: This is a relatively small, early-stage study (100 participants) comparing two device approaches. The procedure for left bundle area pacing is newer and may have higher technical difficulty or unknown long-term risks.

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Conditions

The condition(s) this trial relates to.

atrioventricular block third-degree atrioventricular block

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEFT BUNDLE BRANCH AREA PACING

Contacts and locations

Locations

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

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