Pain management study for opioid users on buprenorphine withdrawn before it began

NCT ID NCT04091009

Terminated Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to compare two ways of managing pain after surgery in people taking buprenorphine for opioid use disorder. One group would continue their usual dose, while the other would receive a lower dose around the time of surgery. The goal was to see which approach better controls pain and reduces cravings or relapse. However, the study was withdrawn before any participants were enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: buprenorphine/naloxone
What this could lead to: If successful, this could help guide doctors on whether to lower or maintain buprenorphine doses during surgery to better manage pain and reduce relapse risk.
What could go wrong: The study was withdrawn before enrolling any participants, so no results are available. The approach may not work as hoped, and individual responses to dose changes can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE DISORDER, MILD OPIOID-USE DISORDER

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Other studies related to the condition(s) this trial covers.