Swallow a pill to track esophagus changes: new study tests No-Sedation monitoring

NCT ID NCT03459339

Ongoing Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 500 adults with Barrett's esophagus for 3 years using a tethered capsule endomicroscopy device—a pill-sized camera that patients swallow. The goal is to track how the condition changes over time without needing sedation or a traditional endoscopy. Researchers hope this approach could make monitoring easier and more comfortable for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simpler, less invasive way to monitor Barrett's esophagus over time.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to any new therapy or change in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Barrett esophagus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARRETT ESOPHAGUS

Contacts and locations

Locations

Columbia University Medical Center

New York, New York, 10032, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
VA Medical Center

Kansas City, Missouri, 64128, United States

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