Can ritalin Jump-Start the brain after a coma?
NCT ID NCT03814356
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests whether a stimulant drug (methylphenidate, also known as Ritalin) given through an IV can safely help people with severe brain injuries regain consciousness. Ten adults in a coma or minimally conscious state will receive increasing doses to check for side effects like dangerous spikes in blood pressure or brain pressure. The study is too small to prove the drug works, but it lays the groundwork for future research.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- methylphenidate (Ritalin) given intravenously
- What this could lead to
- If safe and effective, this could point toward a treatment to help awaken patients with severe brain injuries.
- What could go wrong
- This is a very early Phase 1 safety study with only 10 participants, so it cannot prove the drug works. Risks include high blood pressure, fast heart rate, and increased brain pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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