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Brain seizures after cardiac arrest: can early treatment save lives?

NCT ID NCT06549426

Disease control Sponsor: University of Twente Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial studies whether giving anti-seizure medication to comatose patients who have brain seizure activity after cardiac arrest can improve their recovery. Participants are randomly assigned to receive either standard care alone or standard care plus a stepwise anti-seizure treatment. The study measures functional recovery and healthcare costs to see if the treatment makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
anti-seizure medication and sedative agents
What this could lead to
If effective, this approach could improve functional recovery and quality of life for comatose patients after cardiac arrest.
What could go wrong
This is a mid-stage trial with 150 participants, so results may not apply broadly. Anti-seizure drugs can cause side effects like sedation or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Coma (Glasgow Coma Scale score ≤ 8) after out of hospital cardiac arrest and resuscitation 2. Age ≥ 18 years 3. Continuous EEG with at least eight electrodes started \< 24h after return of spontaneous circulation (ROSC) 4. ESE or possible ESE according to the Salzburg and ACNS criteria 5. Possibility to start treatment within three hours after detection of ESE Exclusion Criteria: 1. Known history of another medical condition with limited life expectancy (\< six months) 2. Any progressive brain illness, such as a brain tumor or neurodegenerative disease 3. Pre-admission Glasgow Outcome Scale score of 3 or lower 4. Reason other than the neurological condition to withdraw treatment 5. EEG background activity prior to the emergence of ESE indicative of extensive irreversible anoxic brain injury 6. Follow-up impossible due to logistic reasons, for example not living in the Netherlands or Belgium

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Conditions

The condition(s) this trial relates to.

Coma developmental and/or epileptic encephalopathy with spike-wave activation in sleep ocular motor apraxia, Cogan type Status Epilepticus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMA Electrographic status epilepticus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    20 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Amphia Ziekenhuis

    NOT_YET_RECRUITING

    Breda, Netherlands

  • Amsterdam University Medical Center

    RECRUITING

    Amsterdam, Netherlands

  • Canisius Wilhelmina Hospital

    ACTIVE_NOT_RECRUITING

    Nijmegen, Netherlands

  • Catharina Hospital

    RECRUITING

    Eindhoven, Netherlands

  • Centre Hospitalier Chrétien - MontLégia

    RECRUITING

    Liège, Belgium

  • Centre Hospitalier Universitaire Marie Curie

    RECRUITING

    Charleroi, Belgium

  • Centre Hospitalier Universitaire Saint-Pierre

    RECRUITING

    Ottignies, Belgium

  • Centre Hospitalier Universitaire Sart-Tilmant

    RECRUITING

    Liège, Belgium

  • Centre Hospitalier Universitaire Tivoli

    RECRUITING

    Louvière, Belgium

  • Erasmus University Medical Center

    RECRUITING

    Rotterdam, Netherlands

  • Haga Ziekenhuis

    NOT_YET_RECRUITING

    The Hague, Netherlands

  • Hôpital Universitaire de Bruxelles

    RECRUITING

    Brussels, Belgium

  • Leiden University Medical Center

    NOT_YET_RECRUITING

    Leiden, Netherlands

  • Maasstad Hospital

    RECRUITING

    Rotterdam, Netherlands

  • Medical Spectrum Twente

    RECRUITING

    Enschede, Netherlands

  • Radboud University Medical Center

    RECRUITING

    Nijmegen, Netherlands

  • Rijnstate Hospital

    RECRUITING

    Arnhem, Netherlands

  • St. Antonius Hospital

    RECRUITING

    Nieuwegein, Netherlands

  • Universitair Ziekenhuis Brussel

    RECRUITING

    Brussels, Belgium

  • University Medical Center Groningen

    RECRUITING

    Groningen, Netherlands

  • VieCuri Medical Center

    RECRUITING

    Venlo, Netherlands

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