COMA

This trial studies whether giving anti-seizure medication to comatose patients who have brain seizure activity after cardiac arrest can improve their recovery. Participants are randomly assigned to receive either standard care alone or standard care plus a stepwise anti-seizure t…

This trial tests whether a new method of clearing mucus from the airways—using intermittent suction through a breathing tube—works better than the standard continuous suction method in comatose patients who have had a stroke. About 600 participants will be randomly assigned to on…

Some people with severe traumatic brain injury appear unresponsive but may still be aware—a hidden state called cognitive motor dissociation. This pilot trial tests whether gentle electrical pulses delivered through clips on the left ear, stimulating two nerves at once (the vagus…

This study tracks 90 coma patients in intensive care to see if their body's natural daily rhythms (like sleep-wake cycles) return as they wake up. Researchers will measure behavior, eye movements, temperature, and urine biomarkers every few hours. The goal is to better understand…

This study tests whether advanced MRI scans that map the brain's structural and functional connections can better predict neurological recovery in coma patients after cardiac arrest than standard methods. Researchers will scan 263 adults who remain unconscious at least 72 hours a…

This observational study tests whether a non-invasive headband called fNIRS can measure brain activity in healthy adults and in people with disorders of consciousness, such as coma, after severe brain injury. Participants wear the headband while receiving gentle touch, listening …

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study uses a special PET scan to look at dopamine pathways in the brains of people who are in a coma after a severe head injury. Researchers will compare three groups: coma patients, patients who have recovered from coma, and healthy volunteers. The goal is to understand how…

This study tests a new tool called PRECOM that uses brain wave signals to predict whether coma patients after cardiac arrest will wake up within three months. Researchers will enroll 100 adults in French ICUs and compare the tool's predictions to actual outcomes. The goal is to i…