Massachusetts General Hospital

This study tested a combination of two drugs, umbralisib and rituximab, as the first treatment for people with follicular lymphoma or marginal zone lymphoma. The goal was to see how many patients had their cancer completely disappear. The study was stopped early and included 18 a…

This study tested a drug called MBG453 in people with a type of bone marrow disorder called lower-risk myelodysplastic syndromes (MDS). The drug is an antibody that targets a protein called TIM3 to help control the disease. Only 10 people took part before the study was stopped ea…

This study tested a combination of two drugs—enzalutamide (already approved for prostate cancer) and tivozanib (an experimental drug that cuts off tumor blood supply)—in men with advanced prostate cancer that had stopped responding to hormone therapy. The goal was to see if the c…

This study tested whether breathing in nitric oxide gas could keep people with mild or moderate COVID-19 from getting sick enough to need a breathing tube. Researchers enrolled 62 hospitalized adults who were still breathing on their own. The trial was stopped early, so results a…

This small pilot study tested whether adding radiation therapy could help CAR T-cell treatment work better in people with lymphoma that did not respond to CAR T alone. Only 3 participants were enrolled before the study was stopped early. The main goal was to check safety and side…

This study aimed to see if breathing in nitric oxide gas could protect healthcare workers from catching COVID-19 while caring for infected patients. It planned to enroll 470 participants but was stopped early with only 24 people. The trial compared those who inhaled the gas to th…

This study tested whether pramipexole, a drug for restless legs syndrome, could reduce both restless legs symptoms and ongoing opioid withdrawal in people being treated for opioid use disorder. The goal was to help patients feel better and stay in their recovery program. The stud…

This study tested a new cooling device designed to reduce pain during radio-frequency microneedling, a cosmetic skin treatment. Six healthy women participated to see how well the device cooled the skin and eased discomfort. The study was terminated early, so results are limited.

This study looked at whether adding guanfacine to opioid treatment could reduce the extra pain sensitivity that sometimes develops from long-term opioid use. It involved 8 adults with chronic neck or back pain who were already taking opioids. The study was stopped early, so resul…

This study aimed to see if naproxen sodium, a common anti-inflammatory drug, could reduce obsessive-compulsive symptoms in children with PANDAS, a condition linked to strep infections. The trial planned to enroll children aged 6 to 15 with new-onset OCD, but was terminated early …

This study tested whether memantine, a medication for memory, could improve social skills in youth aged 8-18 with autism or nonverbal learning disorder. The trial was stopped early after enrolling only 25 participants. Researchers measured social improvement using clinician ratin…

This study tested a laser treatment to improve thick scars and scleroderma, a condition that hardens the skin. Researchers wanted to see if the laser could help the skin heal and look better. Only 6 people took part, and the study was stopped early, so results are limited.

This study looked at how healthy adults respond to breathing air with less oxygen for up to 7 days. Researchers measured oxygen levels in the blood, red blood cell production, and lung pressure to understand safety and body changes. Only 5 people took part before the study was st…

This study looked at whether adding guanfacine (a blood pressure medicine) to morphine could reduce a condition called opioid-induced hyperalgesia, where opioids actually make people more sensitive to pain. It involved 137 adults with chronic neck or back pain who had not taken o…

This study aimed to help astronauts on long space trips stay focused and perform well under stress. Researchers tested a system that uses biosensors to adjust the work environment in real time. The study included 80 healthy adults and measured thinking speed and attention. The tr…

This study looked at how a gentle brain stimulation technique called tDCS affects thinking and behavior in children aged 10-17 with obsessive-compulsive disorder (OCD). The goal was to understand the brain processes behind OCD, not to treat it. The study was stopped early and inc…

This study tested whether a non-invasive technique called transcranial magnetic stimulation (TMS) could improve memory in older adults with or without mild memory problems due to Alzheimer's. Researchers used TMS to stimulate brain areas involved in memory and measured changes wi…

This study tested a special band called AirGo to monitor breathing patterns in hospitalized COVID-19 patients with respiratory failure. The goal was to see if the band could detect early signs of worsening breathing, which might help doctors decide when to use a breathing tube. T…

This study looked at two different ways to set a breathing machine for people with severe lung injury (ARDS). The goal was to see which method helps lungs work better and puts less strain on the heart. Only 2 people took part before the study was stopped early, so results are ver…

This study aimed to understand how paresthesia-free spinal cord stimulation (PF-SCS) relieves chronic pain and affects sensation. Researchers planned to enroll 10 adults already using PF-SCS for chronic pain. The study was terminated early, so results are limited.