Massachusetts General Hospital
Clinical trials sponsored by Massachusetts General Hospital, explained in plain language.
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Could a new drug duo slow advanced prostate cancer?
Disease control TerminatedThis study tested if combining two drugs, tivozanib and enzalutamide, could better control advanced prostate cancer that had stopped responding to standard hormone therapy. It aimed to see if the combination could delay cancer growth longer than enzalutamide alone. The trial was …
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Apr 01, 2026 23:26 UTC
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Immune-Boosting drug tested for blood disorder in patients out of options
Disease control TerminatedThis study tested an experimental drug called MBG453 for adults with a lower-risk form of myelodysplastic syndromes (MDS), a bone marrow disorder. The drug is designed to help the patient's own immune system better recognize and attack the abnormal blood cells. The trial was for …
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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New drug combo tested to control blood cancers in First-Time patients
Disease control TerminatedThis study tested a two-drug combination as the first treatment for people newly diagnosed with certain slow-growing blood cancers called follicular lymphoma or marginal zone lymphoma. The goal was to see if adding the experimental drug umbralisib to the approved drug rituximab c…
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Breathing treatment tested to keep COVID patients off ventilators
Disease control TerminatedThis study tested whether inhaling nitric oxide gas could prevent mild or moderate COVID-19 from progressing to severe disease requiring a ventilator. It involved 70 hospitalized patients who were still breathing on their own. The goal was to see if this early treatment could red…
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:29 UTC
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Could a blood pressure drug fix a major opioid problem?
Disease control TerminatedThis study tested whether adding the drug guanfacine to morphine could help people with chronic back or neck pain. The goal was to see if guanfacine could prevent two common problems with long-term opioid use: increased pain sensitivity (where pain feels worse) and needing higher…
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:19 UTC
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Radiation boost after CAR-T: a new shot at fighting stubborn lymphoma
Disease control TerminatedThis small, early-stage study tested whether adding a short course of radiation therapy could help control lymphoma that did not fully respond to CAR-T cell therapy. The goal was to see if radiation could improve the body's immune response against the cancer and work together wit…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:17 UTC
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Could a gas shield doctors from COVID-19?
Prevention TerminatedThis study aimed to see if healthcare workers could be protected from catching COVID-19 by inhaling nitric oxide gas, which has shown antiviral effects against similar viruses. It planned to enroll 470 workers to compare those receiving the gas treatment with those who did not. T…
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Prevention
Last updated Mar 31, 2026 12:11 UTC
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Could a common RLS drug help people stick with opioid addiction treatment?
Symptom relief TerminatedThis study tested whether a medication called pramipexole, commonly used for Restless Legs Syndrome (RLS), could help people recovering from opioid addiction. Researchers wanted to see if reducing RLS and withdrawal symptoms would help participants start and stay in their addicti…
Phase: PHASE2, PHASE3 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Could a common dementia drug help kids with autism make friends?
Symptom relief TerminatedThis study tested whether a medication called memantine (brand name Namenda), which is usually used for Alzheimer's disease, could help improve social skills in children and teens with autism spectrum disorder or similar conditions. Researchers enrolled 25 participants aged 8-18 …
Phase: PHASE3 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Mar 30, 2026 14:34 UTC
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Could a common pain reliever calm a Child's sudden OCD?
Symptom relief TerminatedThis study tested whether naproxen sodium (the medicine in Aleve) could reduce obsessive-compulsive symptoms in children with PANDAS, a condition where strep infections trigger sudden neuropsychiatric problems. It was a small, controlled trial comparing the drug to a placebo pill…
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Mar 30, 2026 14:30 UTC
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Doctors test secret pain settings in spinal implants
Symptom relief TerminatedThis study tested whether lower-intensity settings on spinal cord stimulators could still effectively relieve chronic pain. Researchers secretly switched 10 patients with implanted devices to lower settings to see if their pain returned. The goal was to better understand how thes…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Mar 25, 2026 14:09 UTC
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Laser zaps skin conditions in small trial
Symptom relief TerminatedThis study aimed to see if a specific laser treatment could improve the look and feel of raised scars and scleroderma, a condition that causes skin hardening. Researchers planned to treat 20 adults with these conditions and measure changes in skin appearance and texture. The stud…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Mar 25, 2026 14:08 UTC
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Could common blood pressure drug fix opioid pain problem?
Symptom relief TerminatedThis study tested whether adding the blood pressure medication guanfacine to standard opioid treatment could reduce a specific side effect where opioids actually make people more sensitive to pain over time. It involved 120 adults with chronic back or neck pain who were already t…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Mar 23, 2026 15:17 UTC
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Doctors test if a 'Fuller Lung' eases heart strain in critically ill patients
Knowledge-focused TerminatedThis study aimed to find the best way to set ventilator pressure for patients with severe lung failure (ARDS). Researchers compared two standard techniques to see which one improved oxygen levels while putting less strain on the heart. The study was terminated early after enrolli…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:43 UTC
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Wristband tried to predict COVID breathing crises
Knowledge-focused TerminatedThis study tested a special wristband called the AirGo to monitor the breathing patterns of hospitalized COVID-19 patients who were breathing on their own. The goal was to see if the band could detect patterns that signal a patient's breathing is getting worse and might require a…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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Zapping the brain to fight memory loss
Knowledge-focused TerminatedThis study tested whether using magnetic pulses to stimulate specific brain areas could improve memory in older adults with very early signs of Alzheimer's disease. Researchers used brain scans to see how the stimulation changed brain network connections and gave memory tests to …
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:30 UTC
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Scientists put healthy volunteers in Low-Oxygen tents for a week
Knowledge-focused TerminatedThis study aimed to understand the safety and body's response to breathing low-oxygen air for five days. It enrolled a small number of healthy young adults who stayed in a hospital setting. The goal was to gather data for future research, not to treat any disease.
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Mar 25, 2026 14:08 UTC
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Scientists zap Kids' brains to unlock OCD secrets
Knowledge-focused TerminatedThis small, terminated study aimed to understand how a mild, non-invasive brain stimulation technique affects specific thinking patterns in children with obsessive-compulsive disorder (OCD). Researchers tested how stimulation influenced things like impulse control and fear memory…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:02 UTC