Massachusetts General Hospital

This study aims to see if six months of estrogen replacement therapy improves markers of heart health in women with primary ovarian insufficiency (early menopause). Researchers will measure blood vessel function and other health markers in 45 women before and after starting stand…

This study tests whether a combination of smartphone messages and optional clinician sessions can help adults cope with suicidal thoughts and prevent suicide-related events after they leave a psychiatric hospital. 360 adults who were hospitalized for suicidal thoughts or attempts…

This study aims to see if the medication eplerenone improves heart blood flow and structure better than the medication chlorthalidone in women who had preeclampsia during pregnancy and now have ongoing high blood pressure. About 90 participants will take one of the two study drug…

This study is comparing two different drug combinations for people newly diagnosed with multiple myeloma who are not eligible for stem cell transplant. About 160 participants will receive either elranatamab or daratumumab, both combined with three other standard myeloma drugs. Th…

This study aims to see if combining a prescription quit-smoking medication (varenicline) with a non-invasive brain stimulation technique (TMS) is more effective at helping adults quit nicotine than the medication alone. Researchers will compare two groups: one gets the real medic…

This early-stage study is testing whether combining two immunotherapy drugs (botensilimab and balstilimab) with targeted radiation can help control a specific type of advanced colorectal cancer that has spread to the liver. It is for patients whose cancer has not responded well t…

This study is testing if a medication called empagliflozin, commonly used for diabetes, can help control gout. Researchers will give the drug or a placebo to 60 adults with gout for 12 weeks to see if it lowers uric acid levels and reduces inflammation. The goal is to gather evid…

This study is testing if adding losartan, a common blood pressure medication, to standard weekly paclitaxel chemotherapy can better control ovarian cancer that has stopped responding to platinum drugs. It will involve about 27 patients with this advanced, treatment-resistant form…

This study is testing if an experimental drug, combined with physical activity, can help people with a specific type of heart failure. The main goals are to see if the treatment helps patients exercise longer and improves their memory and thinking skills. Researchers will compare…

This study is testing whether a financial reward program can help people with alcohol-related liver disease reduce or stop drinking. Participants will be randomly assigned to either receive escalating cash payments for clean blood tests that show reduced alcohol use, or receive s…

This early-stage study aims to see if a pill called NPC-1 (containing parthenolide and ipriflavone) is safe and can change certain markers of Alzheimer's disease in the blood over six months. It will involve 40 adults aged 55+ who have early memory concerns or mild Alzheimer's an…

This pilot study is testing a new peer-led support program called Yuva Sath. It aims to help young people in India who inject drugs stay engaged in their treatment and use HIV prevention services. Researchers will compare 60 participants who receive the program to those who do no…

This study is developing and testing a counseling program for people with HIV in South Africa. The program aims to help participants manage common, interconnected struggles like depression, trauma, and food insecurity, which can make it harder to stick to HIV medication. Research…

This study aims to see if giving a specific inhaler called Airsupra to adults when they leave the emergency room (ER) for an asthma attack helps prevent them from having another attack and needing urgent care within the next 3 months. It will compare this approach to the usual ca…

This study is testing a new counseling tool called SIM-AiR, which helps teens with alcohol use disorder visually map their social circles. The goal is to see if this interactive session helps them identify supportive and risky relationships to aid their recovery. Researchers will…

This study is testing a new drug called ivonescimab for people with advanced non-small cell lung cancer that has specific genetic changes and has stopped responding to standard treatments. It will test the drug by itself in one group of patients, and combined with standard chemot…

This study is testing whether a chatbot powered by AI (like ChatGPT) can be a helpful and acceptable tool for young adults (ages 18-29) who drink at risky levels. Researchers want to see if people will use the chatbot and find it easy and helpful, as a first step before larger st…

This early-phase study is testing the safety of adding a drug called venetoclax to a combined transplant procedure. It is for a very small group of patients who have both a blood cancer that may be cured by a stem cell transplant and advanced kidney failure requiring a kidney tra…

This study aims to find out which of five existing medications works best to prevent relapses in people with neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune disease that can cause vision loss and paralysis. About 160 adults with a specific antibody will be rando…

This early-stage study aims to find a safe dose and check side effects of combining two experimental drugs, ziftomenib and mezigdomide, for people whose acute myeloid leukemia (AML) has returned or not responded to standard treatments. It will enroll about 24 adolescents and adul…

This study is testing whether a 12-week home resistance exercise program can help transgender women and gender-diverse people maintain muscle mass and strength when starting estrogen-based hormone therapy. Researchers will compare 60 participants doing the exercise program to tho…

This study tests whether peer coaches who have recovered from both opioid and tobacco addiction can help others quit smoking. Sixty adults receiving medication for opioid use disorder will be assigned to receive either standard smoking cessation coaching or coaching from a traine…

This study is testing whether a new drug called elinzanetant, designed to treat moderate-to-severe hot flashes, can also improve the health of blood vessels in menopausal women. It will involve 80 women aged 40-65 who have hot flashes and certain risk factors for heart and metabo…

This study is testing whether a drug called canakinumab can reduce dangerous inflammation in the arteries of people who have had a heart attack or stent. It specifically includes people with and without a common age-related genetic change called TET2 CHIP. Researchers will use he…

This study is testing if a daily eating schedule can help people with bipolar disorder who are also overweight. For 8 weeks, one group will eat all their food within an 8-hour window each day, while another group waits. Researchers will check if this schedule helps with weight lo…

This study is testing whether adding an immunotherapy drug called toripalimab to standard chemotherapy is safe and effective for people with a specific type of advanced head and neck cancer. It will involve about 26 adults whose cancer has not spread to distant organs. The main g…

This study is testing a new support program for people taking medication for opioid addiction. It aims to actively connect them with local community recovery centers to provide extra support. Researchers will compare this new approach to standard care in a small pilot trial with …

This study is testing a new, personalized system to help women get the right follow-up care after cervical cancer screening. It will compare standard care against two levels of reminder systems (letters and phone calls) to see which works best at getting patients to complete thei…

This study is testing a new type of combined PET/MRI scan to see if it can better detect and measure scarring (fibrosis) in the bile ducts of people with primary sclerosing cholangitis (PSC). Researchers will compare the new scan results to a standard liver stiffness test (FibroS…

This study is testing a new, more sensitive type of eye scanner. The goal is to see if it can detect the earliest signs of glaucoma by measuring specific light properties in the retina. The study will enroll 20 healthy volunteers to see if the scanner produces clear, high-quality…

This study is testing a new imaging device that attaches to a standard colonoscope to take detailed pictures of the colon lining. Researchers want to see if this device provides clearer images that could help doctors spot polyps or other issues more easily. The device will be use…

This study is testing a new, wearable ultrasound patch to see if it can accurately detect breast lumps or other abnormalities. Researchers will compare the patch's images to those from a standard handheld ultrasound machine. About 50 women undergoing breast health checks will wea…

This study is testing a new type of PET scan to see if it can better detect leftover or returning kidney cancer after a patient's initial treatment. Researchers will give participants a special imaging drug and then perform scans to see if the cancer lights up. The goal is to imp…

This study is testing if a new, rapid test performed right in a clinic can get people with gonorrhea or chlamydia started on antibiotics faster than the usual lab test. Researchers will compare the two testing methods in 400 adults without symptoms. The goal is to see if the fast…

This study tests whether weekly phone or text check-ins from a trained crisis support organization can help prevent suicide attempts in people recently discharged from the emergency room for suicidal thoughts. 300 participants will be randomly assigned to receive these weekly che…

This study is testing whether a diet with more plant foods and less meat can change gut chemicals and bacteria linked to colon cancer. It involves 40 adults who have had a colon polyp removed and currently eat a typical Western diet. Participants will follow a guided diet change …

This study is testing whether taking creatine, a supplement often used by athletes, can help protect the brain in older adults having surgery. Surgery can sometimes cause temporary problems with memory, thinking, and attention. Researchers will give creatine to 80 older adults be…

This study is testing a new support program to prevent suicide attempts in the high-risk weeks after someone leaves the emergency room for suicidal thoughts. A local crisis hotline organization will call or text participants weekly for 12 weeks to check in, discuss coping skills,…

This study aims to find the best way to deliver a highly effective, twice-yearly HIV prevention injection called lenacapavir. It will test if offering people a choice of where to get their follow-up injections—at home, in the community, or at a clinic—helps them stay on the medic…

This study is testing a new program designed to prevent HIV in families. It provides HIV self-test kits to the male partners of new mothers in South Africa and offers counseling to help women start preventive medication (PrEP). The goal is to see if this combined approach is prac…

This study aims to see how well a long-acting, injectable HIV prevention medication works for adults who inject drugs and are at risk for HIV. About 100 participants will receive the injection every two months for seven months, along with support from a dedicated guide to help th…

This study aims to see if a supplement called N-Acetylcysteine (NAC) can help children aged 6-12 who struggle with severe emotional dysregulation, which involves intense mood swings, irritability, and outbursts. Over 8 weeks, 80 children will take either NAC or a placebo (inactiv…

This study is testing whether having patients with advanced kidney disease regularly report their symptoms using an electronic survey helps their doctors provide better care. For 12 months, half of the 70 participants will fill out monthly symptom reports that are shared with the…

This small study is testing two different schedules for combining two cosmetic treatments to improve the appearance of aging skin on the upper arms. It will compare giving a Sculptra injection and a Sofwave ultrasound treatment on the same day versus giving them one month apart. …

This study is testing a new support program called 'Resilient Families' for parents who have a baby in the neonatal intensive care unit (NICU). The goal is to see if the program is practical and helpful for reducing parents' stress, anxiety, and depression while improving their r…

This study is testing whether a special video and support from a trained coach can help parents of children with cancer have clearer, more meaningful conversations with doctors about treatment goals and end-of-life care. It will involve over 500 parents across three major hospita…

This study is testing a program called BREEZE+ to help people with advanced lung cancer manage severe shortness of breath, a very common and distressing symptom. The program involves three brief video calls with a nurse and access to a smartphone app that teaches coping skills. R…

This study is testing whether giving home health aides extra training in dementia care helps reduce difficult behaviors in older adults with memory problems and improves their quality of life, as well as the well-being of their family caregivers. It will involve 60 pairs of patie…

This study is testing a new online support program for people recently diagnosed with ALS and their primary caregiver. The program involves six video sessions over six weeks, focusing on building resilience, coping skills, and finding meaning. Researchers want to see if the progr…

This study is testing whether combining mindfulness training with real-time brain feedback can help reduce repetitive negative thinking in adolescents who are at risk for developing serious mental illness. Researchers will enroll 90 teens and young adults (ages 14-21) who struggl…

This small pilot study is testing whether an 8-week program of text messages from an AI can help adults with type 2 diabetes become more physically active and feel better. The program involves setting weekly activity goals and doing well-being exercises. Researchers will check if…

This study is testing whether a smartphone app can help reduce suicidal thoughts and urges. It will involve 60 adults in the Boston area who have frequent suicidal thoughts. Participants will use the app daily to report their feelings and, for some, the app will deliver brief exe…

This study is testing a support program called COMA-F that aims to reduce emotional distress in family members caring for patients with severe brain injuries who are in a coma. It will compare the program's effectiveness against standard health education materials. The research w…

This study aims to see if the medication buspirone can safely help reduce anxiety in children and teenagers with autism. About 20 participants, aged 7 to 17, will take either buspirone or a placebo (a pill with no medicine) for 16 weeks. Researchers will measure changes in anxiet…

This study is creating and testing a new educational tool designed to help radiation oncology residents learn how to review and improve cancer radiation treatment plans. About 20 resident doctors who have already completed a breast cancer rotation will use the tool and complete s…

This study is testing a training program designed to reduce unconscious racial bias in pharmacists who prescribe PrEP, a daily pill that prevents HIV. The research will involve 70 pharmacy students and will measure whether the training is practical, acceptable, and can reduce bia…

This study aims to identify people with ALS who might qualify for early-stage clinical trials. Participants will undergo health assessments and provide blood samples to check if they match specific trial requirements. The research also creates a database of genetic and health inf…

This study aims to learn if areas of bowel inflammation in people with Crohn's disease or ulcerative colitis are warmer than healthy tissue. During a standard colonoscopy, researchers will use a special temperature probe to measure heat inside the colon. The goal is to gather inf…

This study aims to find out if screening for postpartum depression earlier than usual leads to better identification and care. Researchers will work with 428 new mothers without a history of depression, randomly assigning them to complete a depression questionnaire either at 2-3 …

This study aims to see if adding simple green, yellow, and red nutrition labels to a food bank's online ordering system helps food pantries select healthier items. Researchers will test this by comparing ordering habits between pantries that see the labels and those that don't. T…

This study aims to understand which CPAP (breathing machine) setting works better for heart and lung function in severely obese patients right after they wake up from anesthesia. Researchers will compare a personalized pressure setting to a standard one in 60 participants. The go…

This is a small, early-stage study to see if a laser commonly used for skin rejuvenation can also improve metabolism and body composition. Researchers will give 15 adults with a BMI between 25 and 30 three laser treatments over several months. They will measure body fat, weight, …

This early study aims to see if a special dye called LUMISIGHT can make inflammation inside blocked arteries visible to doctors. Researchers will test it on 25 people with severe carotid or leg artery disease who are already scheduled for surgery. They will compare images of arte…

This study aims to understand how Angelman syndrome naturally progresses over one year in children and adults. Researchers will follow 40 participants, tracking their development, behavior, sleep patterns, and brain activity through regular visits and at-home monitoring. The goal…

This study aims to understand why pregnant women living at very high altitudes in Bolivia are at risk for serious complications like preeclampsia and high blood pressure in the lungs. Researchers will follow 20 women, comparing healthy pregnancies to those with complications, to …