Can estrogen protect hearts in early menopause? new study aims to find out
NCT ID NCT06866119
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This observational study will follow 45 women with primary ovarian insufficiency (POI)—a condition that causes early menopause—who are starting estrogen replacement therapy. Researchers will measure heart health markers before and after 6 months of treatment and compare them to healthy women without POI. The goal is to see if estrogen therapy improves blood vessel function and other metabolic signs related to heart disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
estrogen replacement therapy (transdermal 17beta-estradiol and progesterone)
What this could lead to
If successful, this could provide stronger evidence that estrogen therapy helps protect the heart in women with early menopause.
What could go wrong
This is a small observational study (45 participants) that does not test a new treatment—it only measures existing therapy effects. Results may not apply to all women with POI.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States