New breathing program aims to ease breathlessness in advanced lung cancer

NCT ID NCT06791057

Not yet recruiting Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests a short behavioral program called BREEZE+ to help people with advanced lung cancer manage breathlessness. The program includes three nurse-led sessions and a digital app that teaches breathing and relaxation skills. Researchers will compare this to usual care in 420 participants to see if it reduces breathlessness and related anxiety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brief behavioral intervention (BREEZE+) including nurse-led sessions and a digital health app
What this could lead to: If it works, this could provide a practical, non-drug way to help people with advanced lung cancer feel less breathless and more in control.
What could go wrong: This is a relatively early-stage trial testing a behavioral approach, so the effect may be small or not work for everyone. The intervention requires patient engagement, which may be challenging.

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Conditions

The condition(s) this trial relates to.

Dyspnea lung cancer lung carcinoma lung neoplasm mesothelioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED LUNG CANCER DYSPNEA

Contacts and locations

Locations

Johns Hopkins University

Baltimore, Maryland, 21224, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
University of Miami

Coral Gables, Florida, 33124, United States

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