Could a combined therapy boost HIV care in south africa?

NCT ID NCT06152003

Not yet recruiting Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to develop and pilot a program for people with HIV in South Africa who also face depression, trauma, and food insecurity. Researchers will first explore how these problems interact, then create a treatment called CBT-SA that combines therapy, nutrition support, and case management. The pilot will test whether 60 participants find the program acceptable and feasible, with a focus on improving HIV medication adherence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cognitive Behavioral Therapy for Syndemics and Adherence (CBT-SA) combined with nutritional counseling, food parcels, case management, and linkage to care
What this could lead to: If successful, this could point toward a practical treatment package that improves both mental health and HIV medication adherence in underserved communities.
What could go wrong: This is a very early pilot study with only 60 participants, so results may not apply broadly. The intervention is complex and may be difficult to deliver consistently.

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Conditions

The condition(s) this trial relates to.

Depression HIV infectious disease post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTIONS

Contacts and locations

Locations

University of Cape Town

Cape Town, Western Cape, South Africa

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