New study tests best CPAP settings for obese patients after surgery

NCT ID NCT06287632

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Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will test two different ways of using a breathing machine (CPAP) in 60 severely obese adults after they wake up from anesthesia. The goal is to see which setting better supports heart and lung function. Participants will be monitored with special sensors to measure lung volume and heart performance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Continuous positive airway pressure (CPAP) device
What this could lead to
If successful, this could help doctors choose the best CPAP settings to protect heart and lung function in severely obese patients after surgery.
What could go wrong
This is a small, early-stage study (60 people) that only measures short-term effects. Results may not apply to all patients or lead to changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult patients (≥ 18 years old) scheduled for elective non-cardiothoracic surgery requiring general anesthesia with an endotracheal tube 2. Planned admission to the post-anesthesia care unit (PACU) after surgery 3. BMI ≥ 40 kg/m2 4. At the time of baseline measurements in the PACU, patients meet the following criteria: * Receiving ≤ 6 liters of supplemental nasal cannula oxygen * Alert as defined by a Richmond Agitation Sedation Scale of 0 or -1 * Oriented to person, place, and time Exclusion Criteria: 1. Pregnancy, suspected pregnancy or less than six weeks postpartum Known or current pneumothorax 2. Hemodynamic instability at the time of study assessment in the PACU defined as: * systolic blood pressure \<90 mmHg or \>180 mmHg * mean blood pressure \<60 or \>130 mmHg * Any use of intravenous vasoactive agent * heart rate \< 50 or \> 120 beats per minute 3. Respiratory insufficiency in PACU defined as: * Respiratory rate \> 30 * Oxygen saturation \< 92% * Receiving \> 6 liters of supplemental oxygen 4. Known chronic lung disease requiring supplemental oxygen at home 5. Known systolic heart dysfunction (left ventricular ejection fraction ≤ 30%) 6. Contraindication for esophageal catheter placement: * Known esophageal varices * Known bacterial sinusitis * Recent esophageal, nasopharyngeal, or laryngeal trauma or surgery * Known coagulopathy: including history of thrombocytopenia defined as platelet count \<50,000; presence of hemophilia; known genetic disorder of coagulation (e.g.,deficits of protein C, protein S, von Willebrand factor) or oral and subcutaneous anticoagulation treatment (e.g., heparin, warfarin, and or other oral anticoagulants) 7. Contraindication for electrical impedance tomograph belt placement: * Pacemaker and/or internal cardiac defibrillator * Chest skin injury 8. Concern for study inclusion by the perioperative nurse or anesthesia team

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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