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Blood markers may predict muscle loss after Weight-Loss surgery

NCT ID NCT07806513

Knowledge-focused Sponsor: General Committee of Teaching Hospitals and Institutes, Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

Weight-loss surgery like sleeve gastrectomy can cause significant muscle loss, not just fat loss. This study follows 110 adults for 18 months after surgery to see how muscle mass changes and whether certain blood markers, called myomiRs, along with routine lab tests, can track that loss. Researchers will measure muscle mass using bioelectrical impedance and compare it with blood samples. The goal is to find a simple way to monitor muscle health in this population.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If certain blood markers track muscle loss, doctors might use simple blood tests to monitor patients after bariatric surgery and guide nutrition or exercise plans.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The markers may not reliably reflect muscle loss, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

110 people

The number who actually took part.

Started

Jan 2025

Finished

Aug 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The cohort is deliberately restricted to a single procedure to remove procedure type as a source of heterogeneity in a first-in-population biomarker study, and because sleeve gastrectomy is the predominant operation at the participating center. Participants are assessed before surgery (within one week) and at 3, 6, 12 and 18 months. This schedule captures the front-loaded catabolic window and the plateau established by twelve months. At every visit, participants undergo anthropometry, bioimpedance body composition, muscle function testing, dietary and physical-activity assessment, fasting venepuncture, and recording of medication exposure, tolerance and adverse events.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Consecutive adults (≥18 years) * scheduled for primary laparoscopic sleeve gastrectomy * meeting current ASMBS/IFSO indications for metabolic and bariatric surgery Exclusion Criteria: * revisional or secondary bariatric procedure * chronic kidney disease stage 3 or worse * dialysis or transplantation * chronic liver disease with synthetic dysfunction * active or recently treated malignancy * known neuromuscular or myopathic disease * systemic corticosteroid or anabolic agent exposure within three months * cardiac pacemaker or implantable defibrillator * pregnancy or lactation * clinical evidence of abnormal hydration at baseline * inability to perform handgrip or chair-stand testing

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Conditions

The condition(s) this trial relates to.

morbid obesity Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bariatric surgery Skeletal muscle

Contacts and locations

Locations

  • The surgical department of Medical Research Institute Hospital, Alexandria University

    Alexandria, 21531, Egypt

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