Cure My Disease

Don't miss your cure!

 Log in / Sign up

A daily pill aims to stop overweight from turning into obesity and diabetes

NCT ID NCT07794579

Prevention Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Participants are overweight adults with early signs of these conditions, like prediabetes or prehypertension, and a history of unsuccessful weight loss attempts. The study compares orforglipron against a placebo to see if the drug delays or prevents these health problems.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
orforglipron, an experimental daily oral medication
What this could lead to
If it works, orforglipron could become a daily pill that helps overweight adults avoid progressing to obesity and developing related conditions like type 2 diabetes and high blood pressure.
What could go wrong
This is an early test in a large group, and the drug may not prevent these conditions or may cause side effects. The results will take time and may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 2,001 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have an increased waist-to-height ratio of ≥0.5 * Have at least one pre-obesity-related complication (prediabetes, prehypertension, predyslipidemia) * Have at least one unsuccessful attempt to reduce body weight based on diet and exercise * Have a BMI greater than or equal to 25 to less than or equal to 29.9 kg/m2 or equivalent-/region-specific overweight thresholds Exclusion Criteria: * Have type 1 diabetes, type 2 diabetes, or any other type of diabetes * Do not have a stable body weight within 90 days before screening * Have a documented obesity diagnosis or self-reported history of BMI ≥30 kg/m² (or an equivalent region-specific threshold) * Have taken medications for weight loss, including over-the counter medications or alternative therapies, within 180 days prior to screening * Have a prior or planned surgical treatment or procedure for obesity * Have hypertension or history of hypertension * Have dyslipidemia or history of dyslipidemia

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Obesity, abdominal are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Obesity, Abdominal Overweight prediabetes syndrome Prehypertension hypertensive disorder prevention target inherited lipid metabolism disorder prevention target obesity disorder prevention target type 2 diabetes mellitus prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity, abdominal Overweight Prediabetic state Prehypertension

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    179 sites in 12 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Absolute Clinical Research

    Phoenix, Arizona, 85051, United States

  • Accellacare España

    Alcobendas, 28100, Spain

  • Activian Clinical Research

    Kingwood, Texas, 77339, United States

  • AmBeNet GmbH

    Leipzig, 04107, Germany

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan, 48098, United States

  • Artemis Institute for Clinical Research

    Riverside, California, 92503, United States

  • Biopharma Informatic, LLC

    Houston, Texas, 77043, United States

  • Brigham and Women's Hospital Diabetes Program

    Boston, Massachusetts, 02115, United States

  • C.R.A. Investigación Clínica

    Ferrol, 15402, Spain

  • CAMC Institute for Academic Medicine

    Charleston, West Virginia, 25304, United States

  • CARDIAMET Investigaciones Médicas

    Buenos Aires, C1014ACP, Argentina

  • CCR Ostrava s.r.o

    Ostrava, 702 00, Czechia

  • CEMEDIC

    Buenos Aires, C1407GTN, Argentina

  • CHA Bundang Medical Center, CHA University

    Seongnam-si, 13496, South Korea

  • CIPREC

    Buenos Aires, 1061, Argentina

  • CONEXA Investigacion Clinica S.A.

    Buenos Aires, 1012, Argentina

  • Cahaba Research - Pelham

    Pelham, Alabama, 35124, United States

  • CardioAlem Investigaciones

    San Isidro, 1642, Argentina

  • Care Access - 801 South Power Road, Mesa

    Mesa, Arizona, 85206, United States

  • Care Access - Dalton Walmart

    Dalton, Georgia, 30720, United States

  • Care Access - Decatur

    Decatur, Georgia, 30030, United States

  • Care Access - Houston - Clinical Trials Center by Walmart & Care Access

    Houston, Texas, 77082, United States

  • Care Access - Mauldin

    Mauldin, South Carolina, 29662, United States

  • Care Access - St. Petersburg

    St. Petersburg, Florida, 33710, United States

  • Care Access - Tyler - Clinical Trials Center by Walmart & Care Access

    Tyler, Texas, 75704, United States

  • Cathay General Hospital

    Taipei, 106, Taiwan

  • Cedar Health Research - Euless

    Euless, Texas, 76040, United States

  • Cedar Health Research - Texas Native Health

    Dallas, Texas, 75235, United States

  • Centennial Medical Group

    Columbia, Maryland, 21045, United States

  • Central Research Associates

    Birmingham, Alabama, 35205, United States

  • Central States Research

    Tulsa, Oklahoma, 74136, United States

  • Centro Diagnóstico Bioimagenes

    Lanus, 1824, Argentina

  • Centro Médico Viamonte

    Buenos Aires, C1120AAC, Argentina

  • Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.

    Culiacán, 80230, Mexico

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.

    Ciudad Madero, 89440, Mexico

  • Centro de Investigaciones Clinicas del Litoral

    Santa Fe, S3000FWO, Argentina

  • Centro de Investigaciones Médicas Mar del Plata

    Mar del Plata, 7600, Argentina

  • Centro de Investigaciones Médicas Tucuman

    SAN M. de Tucuman, T4000AXL, Argentina

  • Centro de Salud San Juan de la Cruz

    Pozuelo de Alarcón, 28224, Spain

  • Centro de investigación y control metabólico

    Monterrey, 66465, Mexico

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708, United States

  • China Medical University Hospital

    Taichung, 404332, Taiwan

  • Chosun University Hospital

    Gwangju, 61453, South Korea

  • Christian Medical College Vellore

    Vellore, 632004, India

  • Clinical Renal Associates Ltd.

    Media, Pennsylvania, 19063, United States

  • Clinical Research Associates Inc

    Nashville, Tennessee, 37203, United States

  • Clinical Research Partners, LLC

    Richmond, Virginia, 23226, United States

  • Clinvest Headlands Llc

    Springfield, Missouri, 65807, United States

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Cotton O'Neil Clinical Research Center

    Topeka, Kansas, 66606, United States

  • DCOL Center for Clinical Research

    Longview, Texas, 75605, United States

  • Datta Meghe Institute of Medical Sciences (DMIMS) - Shalinitai Meghe Hospital and Research Center

    Nagpur, 441110, India

  • Dedicated Research Site FutureMeds

    Offenbach, 63065, Germany

  • Desert Oasis Healthcare Medical Group

    Palm Springs, California, 92262, United States

  • Diablo Clinical Research, Inc.

    Walnut Creek, California, 94598, United States

  • Diseno y Planeacion en Investigacion Medica - Guadalajara - Calle Amado Nervo

    Guadalajara, 44600, Mexico

  • Drug Trials America

    Hartsdale, New York, 10530, United States

  • EAP Osona Sud - Alt Congost S.L.P

    Centelles, 08540, Spain

  • EAP Sardenya

    Barcelona, 08025, Spain

  • EFERTUS healthcare s.r.o.

    Brno, 615 00, Czechia

  • Endolife Speciality Hospitals

    Guntur, 522001, India

  • Eternal Heart Care Center and Research Institute

    Jaipur, 302020, India

  • Excel Medical Clinical Trials

    Boca Raton, Florida, 33434, United States

  • Family First Medical Center

    Idaho Falls, Idaho, 83404, United States

  • Flourish Research Acquisition, LLC dba Flourish Research - North Miami

    Miami, Florida, 33138, United States

  • Frontier Clinical Research, LLC

    Kingwood, West Virginia, 26537, United States

  • Fundación Respirar

    Buenos Aires, C1426ABP, Argentina

  • FutureMeds - Madrid

    Madrid, 28003, Spain

  • FutureMeds GmbH

    Berlin, 10629, Germany

  • GMERS Medical College and General Hospital

    Baroda, 390021, India

  • Gastrobariátrica Santa Fe

    Mexico City, 05348, Mexico

  • Great Lakes Clinical Trials - Ravenswood

    Chicago, Illinois, 60640, United States

  • Great Lakes Research Group, Inc.

    Bay City, Michigan, 48706, United States

  • Great Lakes Research Institute

    Southfield, Michigan, 48075, United States

  • HOPE Clinical Research & Wellness

    Conyers, Georgia, 30094, United States

  • Habrypraktik s.r.o.

    Habry, 582 81, Czechia

  • Hallym University Sacred Heart Hospital

    Anyang-si, 14068, South Korea

  • Hanyang University Guri Hospital

    Guri-si, 11923, South Korea

  • Hanyang University Seoul Hospital

    Seoul, 04763, South Korea

  • Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels

    Hohenmölsen, 06679, Germany

  • Headlands Horizons, LLC dba Headlands Research-Brownsville

    Brownsville, Texas, 78526, United States

  • Headlands Research Orlando

    Orlando, Florida, 32803, United States

  • Headlands Research- Sacramento

    Sacramento, California, 95821, United States

  • Headlands Research-El Paso

    El Paso, Texas, 79902, United States

  • Headlands Research-Twin Cities

    Maplewood, Minnesota, 55109, United States

  • Healthy Brain Clinic

    Long Beach, California, 90804, United States

  • Hospital Ascires

    Valencia, 46014, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Vithas La Salud

    Granada, 18008, Spain

  • IDIM - Instituto de Investigaciones Metabólicas

    Ciudad de Buenos Aires, C1012AAR, Argentina

  • IMA Clinical Research Austin

    Austin, Texas, 78745, United States

  • IMA Clinical Research Monroe-Main

    Monroe, Louisiana, 71201, United States

  • IMA Clinical Research San Antonio

    San Antonio, Texas, 78229, United States

  • IMA Clinical Research Warren

    Warren Township, New Jersey, 07059, United States

  • Instituto Centenario

    CABA, 1204, Argentina

  • Instituto Especialidades de la Salud Rosario

    Rosario, 2000, Argentina

  • Instituto Médico de Alta Complejidad San Isidro Sa

    San Isidro, 1642, Argentina

  • Instituto de Cardiología Wolff

    Mendoza, 5500, Argentina

  • Instituto de Investigaciones Clinicas Rosario

    Rosario, S2000CVD, Argentina

  • Instituto de Investigaciones Clínicas San Nicolas

    San Nicolás de los Arroyos, 2900, Argentina

  • Investigaciones Medicas Imoba Srl

    Buenos Aires, C1056ABH, Argentina

  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, Iowa, 50266, United States

  • Jawaharlal Nehru Medical College

    Aligarh, 202002, India

  • Jiangsu Province Official Hospital

    Nanjing, 210008, China

  • Jinan Central Hospital

    Jinan, 250013, China

  • Jothydev's Diabetes and Research Center

    Trivandrum, 695032, India

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • Karnataka Institute of Medical Sciences

    Hubli, 580021, India

  • Kohler & Milstein Research S.A. De C.V.

    Mérida, 97070, Mexico

  • Konyang University Hospital

    Seogu, 35365, South Korea

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Korea University Ansan Hospital

    Ansan-si, 15355, South Korea

  • Kyungpook National University Hospital

    Junggu, 41944, South Korea

  • Latin Clinical Trial Center

    San Juan, 00909, Puerto Rico

  • Lillestol Research

    Fargo, North Dakota, 58104, United States

  • Los Angeles Institute for Metabolic Research

    Los Angeles, California, 90015, United States

  • M3 Wake Research - Las Vegas Cimarron

    Las Vegas, Nevada, 89113, United States

  • MUDr. Alena Vachova

    České Budějovice, 37011, Czechia

  • MUDr. Barbora Diepoltova

    Praha 9 - Klanovice, 190 14, Czechia

  • Medical Care and Research SA de CV

    Mérida, 97070, Mexico

  • Medical Corporation Heishinkai OCROM Clinic

    Suita-shi, 565-0853, Japan

  • Medical Plus Research

    Uherské Hradiště, 686 01, Czechia

  • Medication Management

    Greensboro, North Carolina, 27405, United States

  • Medimanage Research

    Tlalpan, 14050, Mexico

  • Mgcendo Llc

    San Juan, 00921, Puerto Rico

  • Milan Kvapil s.r.o., Diabetologicka ambulance

    Prague, 14900, Czechia

  • Monroe Biomedical Research - Louisville

    Louisville, Kentucky, 40213, United States

  • Mysore Medical College

    Mysore, 570001, India

  • NYC Research INC

    Long Island City, New York, 11106, United States

  • Nanjing First Hospital

    Nanjing, 210006, China

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • New Age Medical Research Corporation

    Miami, Florida, 33186, United States

  • New Phase Research and Development

    Knoxville, Tennessee, 37909, United States

  • Nihonbashi Sakura Clinic

    Chūōku, 103-0025, Japan

  • Ningbo First Hospital

    Ningbo, 315010, China

  • Norcal Endocrinology & Internal Medicine

    San Ramon, California, 94583, United States

  • Orange County Research Center

    Lake Forest, California, 92630, United States

  • Oviedo Medical Research

    Oviedo, Florida, 32765, United States

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana, 70808, United States

  • Pinnacle Research Group, LLC

    Anniston, Alabama, 36207, United States

  • Ponce Medical School Foundation Inc.

    Ponce, 00716, Puerto Rico

  • Precision Clinical Research

    Sunrise, Florida, 33351, United States

  • Pusan National University Yangsan Hospital

    Busan, 50612, South Korea

  • RED-Institut GmbH

    Oldenburg, 23758, Germany

  • Rahman & Detho Studien GmbH

    Obertshausen, 63179, Germany

  • Remington-Davis, Inc

    Columbus, Ohio, 43215, United States

  • Renascor Clinical Research

    Reno, Nevada, 89509, United States

  • Renstar Medical Research

    Ocala, Florida, 34471, United States

  • Riverside Clinical

    Riverside, California, 92506, United States

  • Rochester Clinical Research, LLC

    Rochester, New York, 14609, United States

  • SKY Clinical Research Network Group-Brown

    Atlanta, Georgia, 30331, United States

  • Sanatorio Esperanza

    Esperanza, 3080, Argentina

  • Sanos Clinic

    Ratingen, 40882, Germany

  • Seoul National University Bundang Hospital

    Seongnam, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Servicios Integrales Nova de Monterrey S.A. de C.V.

    San Nicolás de los Garza, 66450, Mexico

  • Sichuan Provincial People's Hospital

    Chengdu, 610072, China

  • Siteworks - Karlsruhe

    Karlsruhe, 76137, Germany

  • Siteworks GmbH - Bochum

    Bochum, 44787, Germany

  • Siteworks GmbH - Hannover

    Hanover, 30449, Germany

  • Solaris Clinical Research

    Meridian, Idaho, 83646, United States

  • Sovah Clinical Research-River District

    Danville, Virginia, 24541, United States

  • Suburban Research Associates

    West Chester, Pennsylvania, 19380, United States

  • Synexus Clinical Research US, Inc./Orange Grove Family Practice

    Tucson, Arizona, 85741, United States

  • The Corvallis Clinic, P.C.

    Corvallis, Oregon, 97330, United States

  • The First Affiliated Hospital of Anhui Medical University

    Hefei, 230022, China

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, 471003, China

  • The First Hospital of Qinhuangdao

    Qinhuangdao Shi, 066000, China

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, 210011, China

  • The Second People's Hospital of Hefei

    Hefei, 230011, China

  • Tianjin Medical University Zhu Xianyi Memorial Hospital

    Tianjin, China

  • Tokyo Asbo Clinic

    Chūōku, 104-0031, Japan

  • Trial Management Associates - Wilmington - Floral Parkway

    Wilmington, North Carolina, 28403, United States

  • Tsuchiura Medical & Health Care Center

    Tsuchiura, 300-0012, Japan

  • VIP Trials

    San Antonio, TX 78230, Texas, 78230, United States

  • Vithas Hospital Sevilla

    Seville, 41950, Spain

  • West Clinical Research

    Morehead City, North Carolina, 28557, United States

  • Yale University School of Medicine

    New Haven, Connecticut, 06519, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.