Could a common supplement calm Kids' mood swings? new trial investigates
NCT ID NCT07323446
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether N-Acetylcysteine (NAC), a supplement, can help children ages 6-12 who struggle with emotional dysregulation (severe mood swings, irritability). Half of the 80 children with emotional dysregulation will receive NAC daily for 8 weeks, while the other half get a placebo. Brain scans before and after treatment will look for changes. The goal is to see if NAC can reduce symptoms like mania and depression, offering a potential new option for families.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
N-Acetylcysteine (NAC)
What this could lead to
If it works, this could point toward a safe, over-the-counter supplement option to help children with emotional dysregulation, reducing mood swings and irritability.
What could go wrong
This is a very early (Phase 1) trial with only 120 participants, so results may not apply broadly. NAC may not improve symptoms, and side effects are not yet well understood in children.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts Institute of Technology
Cambridge, Massachusetts, 02139, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••