Could a quick, dye-free CT scan spot deadly lung clots?

NCT ID NCT07527117

Not yet recruiting Diagnosis Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study explores whether a low-dose CT scan without contrast dye can accurately detect pulmonary embolism (blood clots in the lungs). Researchers will enroll 750 adults suspected of having a clot and add two very low-radiation CT scans to their standard dye-based scan. The goal is to see if the dye-free method can reliably rule out clots, potentially offering a safer option for patients who cannot receive contrast dye.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-dose non-contrast chest CT scan
What this could lead to: If successful, this could offer a safer, dye-free way to diagnose pulmonary embolism, especially for patients who cannot tolerate contrast dye.
What could go wrong: This is an early-stage diagnostic study, not a treatment trial. The new method may not be accurate enough to replace standard scans, and there is a small radiation risk from the extra CT images.

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Conditions

The condition(s) this trial relates to.

disease pulmonary embolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY EMBOLISM (DIAGNOSIS) PULMONARY EMBOLISM ACUTE

Contacts and locations

Locations

Massachusetts General Hospital

Boston, Massachusetts, 02420, United States

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